Correlations Between Triplet Repeat Expansion and Clinical Features in Huntington's Disease

Archives of Neurology

Volumn 52, Issue 8, 1995, Pages 749-753

  Claes, Stephan ^a   Van Zand, Karl ^b   Legius, Erik ^b   Cassiman, Jean Jacques ^b   Dom, René ^b   Malfroid, Michel ^c   Baro, Franz ^c   Godderis, Jan ^b  

^a FUND FOR SCIENTIFIC RESEARCH   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c The Department of Neurology University of Leuven ^*  (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

TRINUCLEOTIDE;

ADULT; AGED; ALLELE; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CLINICAL FEATURE; COGNITIVE DEFECT; CORRELATION FUNCTION; GENETIC CODE; HUMAN; HUNTINGTON CHOREA; MAJOR CLINICAL STUDY; MENTAL DISEASE; ONSET AGE; PRIORITY JOURNAL;

AGE FACTORS; ALLELES; HUMAN; HUNTINGTON DISEASE; MIDDLE AGE; REPETITIVE SEQUENCES, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T;

EID: 0029101386     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneur.1995.00540320021009     Document Type: Article

References (21)

1. Gusella J, Wexler N, Conneally P, et al. A polymorphic DNA marker genetically linked to Huntington's disease. Nature. 1983;306:234-238.
2. Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell. 1993;72:971-983.
3. Strong T, Tagle D, Valdes J, et al. Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues. Nat Genet. 1993;5:259-265.
4. Andrew S, Goldberg P, Kremer B, et al. The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease. Nat Genet. 1993;4:398-403.
5. Duyao M, Ambrose C, Myers R, et al. Trinucleotide repeat length instability and age of onset in Huntington's disease. Nat Genet. 1993;4:387-392.
6. Snell R, MacMillan J, Cheadle J, et al. Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease. Nat Genet. 1993;4:393-397.
7. Kremer B, Goldberg P, Andrew S, et al. A worldwide study of the Huntington's disease mutation. N Engl J Med. 1994;20:1401-1406.
8. Legius E, Cuppens H, Dierick H, et al. Limited expansion of the (CAG)n repeat of the Huntington gene: a premutation (?). Eur J Hum Genet. 1994;2:44-50.
9. Goldberg Y, Kremer B, Andrew S, et al. Molecular analysis of new mutations for Huntington's disease: intermediate alleles and sex of origin effects. Nat Genet. 1993;5:174-179.
10. Andrew S, Goldberg P, Kremer B, et al. The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease. Nat Genet. 1993;4:398-403.
11. Norremolle A, Riess O, Epplen J, Fenger K, Hasholt L, Sorensen S. Trinucleotide repeat elongation in the Huntington gene in Huntington disease patients from 71 Danish families. Hum Mol Genet. 1993;2:1475-1476.
12. Stine O, Pleasant N, Franz M, Abbott M, Folstein S, Ross C. Correlation between the onset age of Huntington's disease and the length of the trinucleotide repeat in IT-15. Hum Mol Genet. 1993;2:1547-1549.
13. Telenius H, Kremer H, Theilmann J, et al. Molecular analysis of juvenile Huntington disease: the major influence on (CAG)n repeat length is the sex of the affected parent. Hum Mol Genet. 1993;2:1535-1540.
14. Duyao M, Ambrose C, Myers R, et al. Trinucleotide repeat length instability and age of onset in Huntington's disease. Nat Genet. 1993;4:387-392.
15. Myers R, Macdonald M, Koroshetz W, et al. De novo expansion of a (CAG)n repeat in sporadic Huntington's disease. Nat Genet. 1993;5:168-173.
16. Macmillan J, Snell R, Tyler A, et al. Molecular analysis and clinical correlation of the Huntington's disease mutation. Lancet. 1993;342:954-958.
17. Hayden MR. Huntington's Chorea. New York, NY: Springer Verlag NY Inc; 1981.
18. Pflanz S, Besson JAO, Ebmeier KP, Simpson S. The clinical manifestation of mental disorder in Huntington's disease: a retrospective case record study of disease progression. Acta Psychiatr Scand. 1991;83:53-60.
19. Di Maio L, Squitieri F, Napolitano G, Campanella G, Trofatter JA, Conneally PM. Onset symptoms in 510 patients with Huntington's disease. J Med Genet. 1993;30:289-292.
20. Read A. Huntington's disease: testing the test. Nat Genet. 1993;4:329-330.
21. Telenius H, Kremer B, Goldberg P, et al. Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm. Nat Genet. 1994; 6:409-414.