메뉴 건너뛰기




Volumn 338, Issue 1-6, 1995, Pages 161-172

Human aging is associated with stochastic somatic mutations of mitochondrial DNA

Author keywords

Allele specific PCR; Human ageing; Maternal inheritance; Mitochondrial disease; Mitochondrial DNA; Molecular basis of aging; Mutations of mtDNA

Indexed keywords

MITOCHONDRIAL DNA;

EID: 0029101232     PISSN: 09218734     EISSN: None     Source Type: Journal    
DOI: 10.1016/0921-8734(95)00021-W     Document Type: Article
Times cited : (115)

References (112)
  • 4
    • 0026621445 scopus 로고
    • Distribution and threshold expression of the tRNALys mutation in skeletal muscle of patients with myoclonic epilepsy and ragged-red fibers (MERRF)
    • (1992) Am. J. Hum. Genet. , vol.51 , pp. 1187-1200
    • Boulet1    Karpati2    Shoubridge3
  • 5
    • 0027327280 scopus 로고
    • Fate and expression deleted mitochondrial DNA differ between human heteroplasmic skin fibroblast and Epstein-Barr virus-transformed lymphocyte cultures
    • (1993) J. Biol. Chem. , vol.268 , pp. 19369-19376
    • Bourgeron1    Chretien2    Rötig3    Munnich4    Rustin5
  • 10
    • 0019429346 scopus 로고
    • Maternal inheritance of mitochondrial DNA polymorphisms in cultured human fibroblasts
    • (1981) Somat. Cell Genet. , vol.7 , pp. 103-108
    • Case1
  • 13
    • 0019978703 scopus 로고
    • Replication of mitochondrial DNA
    • (1982) Cell , vol.28 , pp. 693-705
    • Clayton1
  • 18
    • 0022373294 scopus 로고
    • Purification of nuclear and mitochondrial uracil-DNA glycosylase from rat liver; identification of two distinct subcellular forms
    • (1985) Biochemistry , vol.24 , pp. 7320-7328
    • Domena1    Mosbaugh2
  • 24
    • 0025666322 scopus 로고
    • Leu (UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies
    • (1990) Nature , vol.348 , pp. 651-653
    • Goto1    Nonaka2    Horai3
  • 25
    • 0026004614 scopus 로고
    • A new mtDNA mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)
    • (1991) Biochim. Biophys. Acta , vol.1097 , pp. 238-240
    • Goto1    Nonaka2    Horai3
  • 31
    • 0023883150 scopus 로고
    • Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies
    • (1988) Nature , vol.331 , pp. 717-719
    • Holt1    Harding2    Morgan-Hughes3
  • 32
    • 0025897119 scopus 로고
    • Leber hereditary optic neuropathy: Involvement of the mitochondrial ND1 gene and evidence for an intragenic suppressor mutation (see comments)
    • (1991) Am. J. Hum. Genet. , vol.48 , pp. 935-942
    • Howell1    Kubacka2    Xu3    McCullough4
  • 42
    • 0024448458 scopus 로고
    • Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complementation
    • (1989) Science. , vol.246 , pp. 500-503
    • King1    Attardi2
  • 43
    • 0019861198 scopus 로고
    • Fidelity of mammalian DNA polymerases
    • (1981) Science , vol.213 , pp. 765-768
    • Kunkel1    Locb2
  • 47
    • 0024541837 scopus 로고
    • Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
    • (1989) Lancet , vol.1 , pp. 642-645
    • Linnane1    Marzuki2    Ozawa3    Tanaka4
  • 50
    • 0026746739 scopus 로고
    • A variant of Leber hereditary optic neuropathy characterized by recovery of vision and by an unusual mitochondrial genetic etiology
    • (1992) Am. J. Hum. Genet. , vol.51 , pp. 1218-1228
    • Mackey1    Howell2
  • 51
    • 0015239454 scopus 로고
    • The turnover of mitochondria in a variety of tissues of young adult and aged rats
    • (1971) J. Biol. Chem. , vol.246 , pp. 2425-2429
    • Menzies1    Gold2
  • 57
    • 0024366601 scopus 로고
    • Cytochrome c oxidase deficient cardiomyocytes in the human heart. An age-related phenomenon
    • (1989) Am. J. Pathol. , vol.134 , pp. 1167-1171
    • Müller-Höcker1
  • 58
    • 0025673968 scopus 로고
    • Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age related alteration
    • (1990) J. Neurol. Sci. , vol.100 , pp. 14-21
    • Müller-Höcker1
  • 59
    • 0026705589 scopus 로고
    • Random cytochrome-c oxidase deficiency of oxiphil cell nodules in the parathyroid gland. A mitochondrial cytopathy related to cell ageing?
    • (1992) Pathol. Res. Pract. , vol.188 , pp. 701-706
    • Müller-Höcker1
  • 65
    • 0002248011 scopus 로고
    • Oxygen radical release in mitochondria: influence of age
    • (1986) Mod. Ageing Res. , vol.8 , pp. 77-98
    • Nohl1
  • 66
    • 0025757259 scopus 로고
    • Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin
    • (1991) J. Biol. Chem. , vol.266 , pp. 3113-3117
    • Pettepher1    Ledoux2    Bohr3    Wilson4
  • 73
    • 0023819095 scopus 로고
    • 6-ethylguanine from mitochondrial DNA in rat tissues exposed to N-ethylguanine-N-nitro-surea in vivo
    • (1988) J. Biol. Chem. , vol.263 , pp. 6854-6856
    • Satoh1    Huh2    Rajewsky3    T.4
  • 89
    • 0006861095 scopus 로고
    • Changes in speed of contraction and ATPase activity in striated muscle during old age
    • (1977) Exp. Gerontol. , vol.12 , pp. 31-35
    • Syrovy1    Gutmann2
  • 94
    • 0024241304 scopus 로고
    • Mitochondrial endonuclease activities specific for apurinic/apyrimidinic sites in DNA from mouse cells
    • (1988) J. Biol. Chem. , vol.263 , pp. 12532-12537
    • Tomkinson1    Bonk2    Linn3
  • 96
    • 0024580556 scopus 로고
    • Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing
    • (1989) Lancet , vol.1 , pp. 637-639
    • Trounce1    Byrne2    Marzuki3
  • 100
    • 0026587335 scopus 로고
    • Mitochondrial genetics: a paradigm for aging and degenerative diseases?
    • (1992) Science , vol.256 , pp. 628-632
    • Wallace1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.