Spontaneous and Ionizing Radiation-induced Chromosomal Abnormalities in p53-deficient Mice

Cancer Research

Volumn 55, Issue 17, 1995, Pages 3883-3889

  Bouffler, Simon D ^a   Cox, Roger ^a   Balmain, Allan ^b   Kemp, Christopher J ^c  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^c FRED HUTCHINSON CANCER RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CHROMOSOME ABERRATION; CONTROLLED STUDY; GAMMA IRRADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; RADIATION MUTAGENESIS; SISTER CHROMATID EXCHANGE; SPLEEN CELL; TUMOR SUPPRESSOR GENE;

ANEUPLOIDY; ANIMAL; BONE MARROW; CHROMATIDS; CHROMOSOME ABERRATIONS; GENES, P53; GENOTYPE; KARYOTYPING; MICE; RADIATION, IONIZING; SISTER CHROMATID EXCHANGE; SUPPORT, NON-U.S. GOV'T;

EID: 0029099361     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Levine, A. J., Momand, J., and Finlay, C. A. The p53 tumour suppressor gene. Nature (Lond.), 351: 453–456, 1991.
2. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C. C. p53 mutations in human cancers. Science (Washington DC), 253: 49–53, 1991.
3. Malkin, D., Li, F., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Gryka, G., Bischoff, F. Z., Tainsky, M. A., and Friend, S. H. Germline p53 mutations in a familial syndrome of sarcomas, breast cancer and other neoplasms. Science (Washington DC), 250: 1233–1238, 1990.
4. Srivastava, S., Zou, Z., Pirollo, K., Blattner, W., and Chang, E. H. Germline transmission of a mutated p53 gene in a cancer prone family with Li-Fraumeni syndrome. Nature (Lond.), 348: 747–749, 1990.
5. Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., and Bradley, A. Mice deficient for p53 are developmentally normal but are susceptible to spontaneous tumours. Nature (Lond.), 356: 215–221, 1992.
6. Harvey, M., McArthur, M. J., Montgomery, C. A., Butel, J. S., Bradley, A., and Donehower, L. A. Spontaneous and carcinogen-induced tumorigenesis in p53 deficient mice. Nat. Genet., 5: 225–229, 1993.
7. Kemp, C. J., Wheldon, T., and Balmain, A. p53 deficient mice are extremely susceptible to radiation induced tumorigenesis. Nat. Genet., 8: 66–69, 1994.
8. Purdie, C. A., Harrison, D. J., Peter, A., Dobbie, L., White, S., Howie, S. E. M., Salter, D. M., Bird, C. C., Wyllie, A. H., Hooper, M. L., and Qarke, A. R. Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene. Oncogene, 9: 603–609, 1994.
9. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and Jacks, T. p53 is required for radiation induced apoptosis in mouse thymocytes. Nature (Lond.), 362: 847–849, 1993.
10. Qarke, A. R., Purdie, C. A., Harrison, D. J., Morris, M. G., Bird, C. C., Hooper, M. L., and Wyllie, A. H. Thymocyte apoptosis induced by p53 dependent and independent pathways. Nature (Lond.), 362: 849–852, 1993.
11. Merritt, A. J., Potten, C. S., Kemp, C. J., Hickman, J. A., Lane, D. P., and Hall, P. A. The role of spontaneous and radiation induced apoptosis in the gastrointestinal tract of normal and p53 deficient mice. Cancer Res., 54: 614–617, 1994.
12. Lotem, J., and Sachs, L. Haemopoietic cells from mice deficient in wild type p53 are more resistant to induction of apoptosis by some agents. Blood, 82:1092–1096,1993.
13. Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R. W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res., 57: 6304–6311, 1991.
14. Kuerbitz, S. J., Plunkett, B. S., Walsh, W. V., and Kastan, M. B. Wild type p53 is a cell cycle checkpoint determinant following radiation. Proc. Natl. Acad. Sci. USA, 89: 7491–7495, 1992.
15. Livingstone, L. R., White, A., Sprouse, J., Livanos, E., Jacks, T., and Tlsty, T. Altered cell cycle arrest and gene amplification potential accompanying loss of wild type p53. Cell, 70: 925–935, 1992.
16. Yin, Y., Tainsky, M. A., Bischoff, F. Z., Strong, L. C., and Wahl, G. M. Wild type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell, 70: 937–948, 1992.
17. Lane, D. P. p53, guardian of the genome. Nature (Lond.), 358: 15–17, 1992.
18. Bischoff, F. Z., Yim, S. O., Pathak, S., Grant, G., Siciliano, M. J., Giovanella, B. C., Strong, L. C., and Tainsky, M. A. Spontaneous abnormalities in fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalisation. Cancer Res., 50: 7979–7984, 1990.
19. Harvey, M., Sands, A. T., Weiss, R. S., Hcgi, M. K., Wiseman, R. W., Pantazis, P., Giovanella, B. C., Tainsky, M. A., Bradley, A., Donehower, L. A. In vitro growth characteristics of embryo fibroblasts isolated from p53 deficient mice. Oncogene, 8: 2457–2467, 1993.
20. Piper, J., and Breckon, G. An automated system for karyotyping mouse chromosomes. Cytogenet. Cell Genet., 50: 111–115, 1989.
21. Kemp, C. J., Donehower, L. A., Bradley, A., and Balmain, A. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumours. Cell, 74: 813–822, 1993.
22. Lee, J. J., Warburton, D., and Robertson, E. J. Cytogenetic methods for the mouse: preparation of chromosomes, karyotyping and in situ hybridization. Anal. Biochem., 189: 1–17, 1990.
23. Perry, P., and Wolff, S. A new Giemsa method for the differential staining of sister chromatids. Nature (Lond.), 251: 156–158, 1974.
24. UNSCEAR, United Nations Scientific Committee on the Effects of Atomic Radiation. UNSCEAR1993 Report to the General Assembly, Annex E, Mechanisms of radiation oncogenesis. New York: United Nations, 1993.
25. UNSCEAR, United Nations Scientific Committee on the Effects of Atomic Radiation. UNSCEAR 1994 Report to the General Assembly, Annex A, Epidemiological studies of radiation carcinogenesis. New York: United Nations, 1994.
26. Solomon, E., Borrow, J., and Goddard, A. D. Chromosome aberrations and cancer. Science (Washington DC), 254: 1153–1160, 1991.
27. Rabbitts, T. H. Chromosomal translocations in human cancer. Nature (Lond.), 372: 143–149, 1994.
28. Wolff, S., Bodycote, J., and Painter, R. B. Sister chromatid exchanges induced in Chinese hamster cells by UV irradiation at different stages of the cell cycle: the necessity of cells to pass through S. Mutat. Res., 25: 73–81, 1974.
29. Schvartzman, J. B., and Gutierrez, C. The relationship between the cell time available for repair and the effectiveness of a damaging treatment in provoking the formation of sister chromatid exchanges. Mutat. Res., 72: 483–489, 1980.
30. Perry, P., and Evans, H. J. Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange. Nature (Lond.), 261: 156–158, 1975.
31. Solomon, E., and Bobrow, M. Sister chromatid exchanges: a sensitive assay of agents damaging human chromosomes. Mutat. Res., 30: 273–278, 1975.
32. Sanford, K. K., Parshad, R., Gantt, R., Tarone, R. E., Jones, G. M., and Price, F. M. Factors affecting and significance of G2 chromatin radiosensitivity in predisposition to cancer. Int. J. Radiat. Biol., 55: 963–981, 1989.
33. Wilcock, D., and Lane, D. P. Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes infected cells. Nature (Lond.), 349: 429–431, 1991.
34. Li, F. F., and Fraumeni, J. F., Jr. Rhabdomyosarcoma in children: epidemiological study and identification of a familial cancer syndrome. J. Natl. Cancer Inst., 43: 1365–1373, 1969.
35. Li, F. P., Fraumeni, J. F., Jr., Mulvihill, J. J., Blattner, W. A., Dreyfus, M. G., Tucker, M. A., and Miller, R. W. A cancer family syndrome in twenty four kindreds. Cancer Res., 48: 5358–5362, 1988.
36. Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., and Shay, J. W. Specific association of human telomerase activity with immortal cells and cancer. Science (Washington DC), 266: 2011–2015, 1994.
37. Harvey, M., Vogel, H., Morris, D., Bradley, A., Bernstein, A., and Donehower, L. A. A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53 deficient mice. Nat. Genet., 9: 305–311, 1995.
38. Parshad, R., Price, F. M., Pirollo, K. F., Chang, E. H., and Sandford, K. K. Cytogenetic responses to G2 phase X-irradiation in relation to DNA repair and radiosensitivity in a cancer prone family with Li-Fraumeni syndrome. Radiat. Res., 136: 236–240, 1993.
39. Sanford, K. K., and Parshad, R. Detection of cancer prone individuals using cytogenetic response to X-rays. In: G. Obe and A. T. Natarajan (eds.) 0, Chromosomal Aberrations: Basic and Applied Aspects, pp. 113–120. Berlin: Springer-Verlag, 1990.
40. Scott, D., Spreadborough, A., Levine, E., and Roberts, S. A. Genetic predisposition in breast cancer. Lancet, 344: 1444, 1994.
41. Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., and Fornace, A. J., Jr. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia telangiectasia. Cell, 71: 587–597, 1992.
42. Strasser, A., Harris, A. W., Jacks, T., and Cory, S. DNA damage can induce apoptosis via p53 independent mechanisms inhibitable by bc!2. Cell, 79: 329–339, 1994.
43. Lee, J. M., and Bernstein, A. p53 mutations increase resistance to ionizing radiation. Proc. Natl. Acad. Sci. USA, 90: 5742–5746, 1993.
44. Stewart, N., Hicks, G. G., Paraskevas, F., and Mowat, M. Evidence for a second cell cycle block at Gj/M by p53. Oncogene, 10: 109–115, 1995.
45. Cross, S. M., Sanchez, C. A., Morgan, C. A., Schimke, M. K., Ramel, S., Idzerda, R. L., Raskind, W. H., and Reid, B. J. A p53 dependent mouse spindle checkpoint. Science (Washington DC), 267: 1353–1356, 1995.