The influence of smoking and diet on the hypoxanthine phosphoribosyltransferase (hprt) mutant frequency in circulating T lymphocytes from a normal human population

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 331, Issue 1, 1995, Pages 55-64

  Duthie, Susan J ^a   Ross, Marion ^a   Collins, Andrew R ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Antioxidant; Biomarker; Diet; Hprt mutant; Human lymphocytes

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CAROTENE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MITOMYCIN C; RETINOL; XANTHOPHYLL;

ARTICLE; CIGARETTE SMOKING; CONTROLLED STUDY; DIET; HUMAN; HUMAN CELL; MALE; MUTATION RATE; NORMAL HUMAN; PRIORITY JOURNAL; SMOKING; T LYMPHOCYTE;

ADULT; ANTIOXIDANTS; ASCORBIC ACID; DIET; HUMAN; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MALE; MUTATION; SMOKING; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES;

EID: 0029099236     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(95)00051-J     Document Type: Article

References (54)

1. The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers
2. Determination of nicotine and its metabolite cotinine, in urine by gas chromatography
3. Diverse carotenoids protect against chemically induced neoplastic transformation
4. Vitamin C and cancer prevention: the epidemiologic evidence.
5. The data supporting a role for antioxidants in reducing cancer risk
6. Factors influencing mutation at the hprt locus in T-lymphocytes: woman treated for breast cancer
7. Factors influencing mutation at the hprt locus in T-lymphocytes: studies in normal women and women with benign and malignant breast masses
8. Measurement of HPRT mutant frequencies in T-lymphocytes from healthy human populations
9. Dietary carotenes, vitamin C, and vitamin E as protective antioxidants in human cancers
10. In vivo somatic mutation in the lymphocytes of Hodgkin's disease patients
11. Free-radical chemistry of cigarette smoke and its toxicological implications
12. Free radicals in chemical carcinogenesis
13. Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo
14. A further assessment of factors influencing measurements of thioguanine-resistant mutant frequency in circulating T-lymphocytes
15. HPRT somatic mutation data
16. HPRT mutant frequencies in circulating lymphocytes: population studies using normal donors, exposed groups and cancer-prone syndromes
17. Elevated hprt mutant frequency in circulating T-lymphocytes of xeroderma pigmentosum patients
18. Micronutrients and oxidative stress in the aetiology of cancer
19. Relationship between carotenoids and cancer: the multiple risk factor intervention trial (MRFIT) study
20. The metal-mediated formation of hydroxyl radical by aqueous extracts of cigarette tar
21. Oxygen radicals and human disease
22. Thioguanine-resistant mutant frequency in T-lymphocytes from a healthy human population
23. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today
24. Antioxidant micronutrients in cancer prevention
25. Antioxidant hypothesis of cardiovascular disease
26. Oxidants, Antioxidants and Cardiovascular Disease
27. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm
28. Anticarcinogenic effect of common carotenoids
29. Free radicals, antioxidants and human disease; where are we now?
30. Dietary inhibitors of mutagenesis and carcinogenesis
31. Detection of somatic mutations in man: evaluation of the microtitre cloning assay for T-lymphocytes
32. Simultaneous determination of retinol, tocopherols, carotenes and lycopene in plasma by means of high-performance liquid chromatography on reversed phase
33. Cigarette smoke condensates damage DNA in human lymphocytes
34. Dietary antioxidants and the risk of lung cancer
35. Vitamin E and cancer prevention
36. In vivo hprt mutant frequencies in T-cells of normal human newborns
37. Diet and cancer
38. Cigarette smoke induces DNA single-strand breaks in human cells
39. Vegetable and fruit consumption and cancer risk
40. Refinement of a T-lymphocyte cloning assay to quantify the in vivo thioguanine-resistant mutant frequency in humans
41. Determination of ascorbic acid and uric acid in plasma by high-performance liquid chromatography
42. Protection by betacarotene and related compounds against oxygenmediated cytotoxicity and genotoxicity; implications for carcinogenesis and anticarcinogenesis
43. Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients. III: measurement of mutant frequency to 6-thioguanine resistance
44. The Scottish Diet
45. Dietary modulation of DNA damage in humans
46. Plasma antioxidant vitamins and subsequent cancer mortality in the 12-year follow up of the prospective Basel study
47. Vegetables, fruit, and cancer
48. Use of the clonal assay for the measurement of hprt mutants in T-lymphocytes from five control populations
49. Frequencies of HPRT mutants and micronuclei in lymphocytes of cancer patients under chemotherapy: A prospective study
50. Measurement of frequencies of HPRT mutants, chromosomal aberrations, micronuclei, sister chromatid exchanges and cells with high frequencies of SCEs in styrene/dichloromethane-exposed workers
51. Biochemical and morphological effects of cigarette smoke condensate and its fractions on normal human bronchial epithelial cells in vitro
52. A review of epidemiological evidence that carotenoids reduce the risk of cancer