Impaired glucose tolerance and increased weight gain in transgenic rats overexpressing a non-insulin-responsive phosphoenolpyruvate carboxykinase gene

Molecular Endocrinology

Volumn 9, Issue 10, 1995, Pages 1396-1404

  Rosella, Gennaro ^a   Zajac, Jeffrey D ^a   Baker, Louise ^b   Kaczmarczyk, Stan J ^a   Andrikopoulos, Sofianos ^a   Adams, Timothy E ^b   Proietto, Joseph ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; KIDNEY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NORTHERN BLOTTING; OBESITY; PRIORITY JOURNAL; TRANSGENIC MOUSE; WEIGHT GAIN;

ANIMAL; ANIMALS, GENETICALLY MODIFIED; BASE SEQUENCE; BODY WEIGHT; FEMALE; GENE EXPRESSION; GLUCOSE; GLUCOSE TOLERANCE TEST; INSULIN; MOLECULAR SEQUENCE DATA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); RATS; SUPPORT, NON-U.S. GOV'T;

EID: 0029098648     PISSN: 08888809     EISSN: 19449917     Source Type: Journal    
DOI: 10.1210/mend.9.10.8544847     Document Type: Article

References (49)

1. Best JD, Judzewitsch RG, Pfeifer MA, Beard JC, Halter JB, Porte D Jr 1982 The effect of chronic sulfonylurea therapy on hepatic glucose production in non-insulindependent diabetes. Diabetes 31: 333-338
2. Consoli A, Nurjhan N, Capani F, Gerich J 1989 Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes 38: 550-557
3. DeFronzo RA, Simonson D, Ferrannini 1982 Hepatic and peripheral insulin resistance: A common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus. Diabetologia 23: 313-319
4. Eriksson J, Franssila-Kallunki A, Ekstrand A, Saloranta C, Widen E, Schalin C, Groop L 1989 Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med 321: 337-343
5. Groop L, Bonadonna R, DelPrato S, Ratheiser K, Zych K, Ferrannini E, DeFronzo RA 1989 Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. J Clin Invest 84: 205-213
6. Firth RG, Bell PM, Marsh HM, Hansen I, Rizza RA 1986 Postprandial hyperglycaemia in patients with noninsulindependent diabetes mellitus; roles of hepatic and extra-hepatic tissue. J Clin Invest 77: 1525-1532
7. O’Rahilly SP, Rudenski AS, Burnett MA, Nugent Z, Hosker JP, Darling P, Turner RC 1986 Beta-cell dysfunction, rather than insulin insensitivity, is the primary defect in familial type 2 diabetes. Lancet 2: 360-363
8. Olefsky JM 1981 Insulin resistance and insulin action: An in vitro and in vivo perspective. Diabetes 30: 148-162
9. DePirro R, Fusco A, Lauro R, Testa I, Ferreti F, DeMartinis C 1981 Erythrocyte insulin receptors in non-insulindependent diabetes mellitus. Diabetes 29: 96-99
10. Trischitta V, Brunetti A, Chiavetta A, Benzi L, Papa V, Vigneri R 1989 Defects in insulin-receptor internalization and processing in monocytes of obese subjects and obese NIDDM patients. Diabetes 38: 1579-1584
11. Freidenberg GR, Reichart D, Olefsky JM, Henry RR 1988 Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss. J Clin Invest 82: 1398-1406
12. Shulman GI, Rothman DL, Jue T, Stein P, DeFronzo RA, Shulman RG 1990 Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulindependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med 322: 223-228
13. Garvey WT, Huecksteadt TP, Matthaei S, Olefsky JM 1988 Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus. J Clin Invest 81: 1528-1536
14. Sinha MK, Raineri-Maldonado C, Buchanan C, Pories WJ, Carter-Su C, Pich PF, Caro JF 1991 Adipose tissue glucose transporters in NIDDM. Decreased levels of muscle/fat isoform. Diabetes 40: 472-477
15. Johnson JH, Ogawa A, Chen L, Orci L, Newgard CB, Alam T, Unger R 1990 Underexpression of fi cell high Km glucose transporters in noninsulin-dependent diabetes. Science 250: 546-549
16. Vionnet N, Stoffel M, Takeda J, Yasuda K, Bell Gl, Zouali H, Lesage S, Velho G, Iris F, Passa Ph, Froguel Ph, Cohen D 1992 Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature 356: 721-722
17. Rossetti L, Smith D, Shulman GI, Papachristou D, DeFronzo RA 1987 Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest 79: 1510-1515
18. Leahy JL, Cooper HE, Deal DA, Weir GC 1986 Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo qlucose infusions. J Clin Invest 77: 908-915
19. Peterson DD, Magnuson MA, Granner DK 1988 Location and characterization of two widely separated glucocorticoid response elements in the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol 8: 96-104
20. Granner D, Andreone T, Sasaki K, Beale E 1983 Inhibition of transcription of the phosphoenolpyruvate carboxykinase gene by insulin. Nature 305: 549-551
21. Rosella G, Zajac JD, Kaczmarczyk SJ, Andrikopoulos S, Proietto J 1993 Impaired suppression of gluconeogenesis induced by overexpression of a noninsulin-responsive phosphoenolpyruvate carboxykinase gene. Mol Endocrinol 7: 1456-1462
22. Pogson Cl, Smith SA 1975 The activity of phosphoenolpyruvate carboxykinase in rat tissues. Assay techniques and effects of dietary and hormonal changes. Biochem J 152: 401-408
23. Andrikopoulos S, Rosella G, Kaczmarczyk S, Zajac J, Prioetto J 1993 Mechanism of hepatic insulin resistance in the New Zealand Obese mouse. Diabetes 42: 1731-1736
24. Meisner H, Loose DS, Hanson RW 1985 Effect of hormones on transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase (GTP) in rat kidney. Biochemistry 24: 421-425
25. Lamers WH, Hanson RW, Meisner HM 1982 CAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei. Proc Natl Acad Sci USA 79: 5137-5141
26. lynedjian PB, Ballard FJ, Hanson RW 1975 The regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in rat kidney cortex. The role of acid-base balance and glucocorticoids. J Biol Chem 250: 5596-5603
27. Brady FO 1991 Induction of metallothionein in rats. In: Riordan JF, Vallee BL (eds) Methods in Enzymology. Harcourt Brace Jovanovich, New York, vol 205: 559-567
28. Valera A, Pujol A, Pelegrin M, Bosch F 1994 Transgenic mice overexpressing phosphoenolpyruvate carboxyki-nase develop non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 91: 9151-9154
29. Tilghman SM, Ballard FJ, Hanson RW 1976 Hormonal regulation of phosphoenolpyruvate carboxykinase (GTP) in mammalian tissues. In: Hanson RW, Mehlman MA (eds) Gluconeogenesis: Its Regulation in Mammalian Species. John Wiley & Sons, New York, pp 47-91
30. Bjorntorp P 1992 Abdominal fat distribution and disease: An overview of epidemiological data. Ann Med 24: 15-18
31. Bjorntorp P 1992 Abdominal obesity and the metabolic syndrome. Ann Med 24: 465-468
32. Traianedes K, Proietto J, O’Dea K 1992 A high fat diet worsens metabolic control in streptozotocin-treated rats by increasing hepatic glucose production. Metabolism 41: 846-850
33. Bevilacqua S, Buzzigoli G, Bonadonna R, Brandi LS, Oleggini M, Boni C, Geloni M, Ferrannini E 1990 Operation of Randle’s cycle in patients with NIDDM. Diabetes 39: 383-389
34. Jeanrenaud B 1978 Hyperinsulinemia in obesity syndromes: Its metabolic consequences and possible etiology. Metabolism [Suppl 2] 27: 1881-1892
35. Reaven GM 1988 Role of insulin resistance in human disease. Diabetes 37: 1595-1607
36. Flax H, Matthews DR, Levy JC, Coppack SW, Turner RC 1991 No glucotoxicity after 53 hours of 6.0 mmol/l hy-perglycaemia in normal man. Diabetologia 34: 570-575
37. Leahy JL, Copper HE, Weir GC 1987 Impaired insulin secretion associated with near normoglycemia: Study in normal rats with 96-h in vivo glucose infusion. Diabetes 36: 459-464
38. Kahn SE, Bergman RN, Schwartz MW, Taborsky GJ Jr, Porte D Jr 1992 Short-term hyperglycemia and hyperinsulinemia improve insulin action but do not alter glucose secretion in normsl humans. Am J Physiol 262: E518-E523
39. Rossetti L, Shulman Gl, Zawalich W, DeFronzo RA 1987 Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest 80: 1037-1044
40. Beale EG, Chrapkiewicz NB, Scoble HA, Metz RJ, Quick DP, Noble RL, Donelson JE, Biemann K, Granner DK 1985 Rat hepatic cytosolic phosphoenolpyruvate carboxykinase (GTP). Structures of the protein, messenger RNA, and gene. J Biol Chem 260: 10748-10760
41. O’Brien RM, Lucas PC, Forest CD, Magnuson MA, Granner DK 1990 Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription. Science 249: 533-537
42. Liebold EA, Guo B 1992 Iron-dependent regulation of ferritin and transferrin receptor expression by the iron-responsive element binding protein. Annu Rev Nutr 12: 345-368
43. Hentze MW, Rouault TA, Caughman W, Dancis A, Harford JB, Klausner RD 1987 A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron. Proc Natl Acad Sci USA 84: 6730-6734
44. Maniatis T, Sambrook J, Fritsch E 1989 Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
45. Brinster RL, Chen HY, Trumbauer ME, Yagle MK, Palmiter RD 1985 Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc Natl Acad Sci USA 82: 4438-4442
46. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159
47. Chang HC, Lane MD 1966 The enzymatic carboxylation of phosphoenolpyruvate. II. Purification and properties of liver mitochondrial phosphoenolpyruvate carboxykinase. J Biol Chem 241: 2413-2420
48. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
49. Eggstein E, Kuhlmann E 1974 Triglycerides and glycerol. Determination after alkaline hydrolysis. In: Bergmeyer HU (ed) Methods of Enzymatic Analysis. Academic Press Inc, New York, pp 1825-1831