Prophylactic Extended-Field Irradiation of Para-aortic Lymph Nodes in Stages IIB and Bulky IB and IIA Cervical Carcinomas: Ten-Year Treatment Results of RTOG 79-20

JAMA: The Journal of the American Medical Association

Volumn 274, Issue 5, 1995, Pages 387-393

  Rotman, Marvin ^a   Choi, Kwang ^a   Pajak, Thomas F ^b   Clery, Michelle ^b   Marcial, Victor ^c   Grigsby, Perry W ^d   Cooper, Jay ^e   John, Madhu ^f  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b RADIATION THERAPY ONCOLOGY GROUP   (United States)

^c Radiation Oncology Center   (Puerto Rico)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^f Kaweah Delta Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BRACHYTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; LYMPH NODE IRRADIATION; MAJOR CLINICAL STUDY; PARAAORTIC LYMPH NODE; PRIORITY JOURNAL; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; UTERINE CERVIX CANCER;

EID: 0029098221     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.1995.03530050035029     Document Type: Article

References (20)

1. Rotman M, Moon S, John M, et al. Extended field para-aortic radiation in cervical carcinoma: the case for prophylactic treatment. Int J Radiat Oncol Biol Phys. 1978;4:795-799.
2. Rotman M, Choi K, Guze C, et al. Prophylactic irradiation of the para-aortic lymph node chain in stage IIB and bulky stage IB carcinomas of the cervix: initial treatment results of RTOG 79-20. Int J Radiat Oncol Biol Phys. 1990;19:513-521.
3. Zelen M. The randomization and stratification of patients to clinical trials. J Chronic Dis. 1974;27: 365-375.
4. Wilcoxon F. Individual comparison by ranking models. Biometrics. 1945;1:80-83.
5. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-481.
6. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chem Rep. 1966;50:163-170.
7. Gelman R, Gelber R, Henderson IC, et al. Improved methodology for analyzing local and distant recurrence. J Clin Oncol. 1990;8:548-555.
8. Gaynor JJ, Feuer EJ, Tan CC, et al. On the use of cause-specific failure and conditional failure probabilities: examples from clinical oncology data. J Am Stat Assoc. 1993;88:400-409.
9. Kalbfleish JD, Prentice RL. The Statistical Analysis of Failure Time Data. New York, NY: John Wiley & Sons Inc; 1980.
10. Gray RJ. A class of K-sample tests for comparing the cumulative incidence of a competing risk. Ann Stat. 1988;16:1141-1154.
11. Cox DR. Regression models and life tables. JR Stat Soc. 1972;34:187-229.
12. Rutledge FN, Fletcher GH. Transperitoneal pelvic lymphadenectomy following supervoltage irradiation for squamous cell carcinoma of the cervix. Am J Obstet Gynecol. 1958;76:321-334.
13. Rotman M, John M. Para-aortic irradiation in cervical carcinoma. Int J Radiat Oncol Biol Phys. 1979;5:2139-2141.
14. Rotman M, Aziz H, Eiffel PJ. Irradiation of pelvic and para-aortic nodes in carcinoma of the cervix. Semin Radiat Oncol. 1994;1:23-29.
15. Rotman M, John M, Boyce J. Prognostic factors in cervical carcinoma: implications in staging and management. Cancer. 1981;48:560-567.
16. Grigsby PW, Vest ML, Perez CA. Recurrent carcinoma of the cervix exclusively in the para-aortic nodes following radiation therapy. Int J Radiat Oncol Biol Phys. 1984;28:451-455.
17. Sotto LSJ, Graham JB, Pickren JW. Post-mortem findings in cancer of the cervix. Am J Obstet Gynecol. 1960;80:791-796.
18. Jampolis S, Andras EJ, Fletcher GH. Analysis of sites and causes of failures of irradiation in invasive squamous cell carcinoma of the intact uterine cervix. Radiology. 1975;115:681-685.
19. Paunier J, Delclos L, Fletcher GH. Causes, time of death, and sites of failure in squamous cell carcinoma of the uterine cervix on intact uterus. Radiology. 1967;88:555-562.
20. Haie L, Pesovic MH, Gerbaulet A, et al. Is prophylactic para-aortic irradiation worthwhile in the treatment of advanced cervical carcinoma? results of a controlled clinical trial of the EORTC radiotherapy group. Radiother Oncol. 1988;11:101-112.