메뉴 건너뛰기




Volumn 86, Issue 5, 1995, Pages 2008-2013

Deferiprone (L1) chelates pathologic iron deposits from membranes of intact thalassemic and sickle red blood cells both in vitro and in vivo

Author keywords

[No Author keywords available]

Indexed keywords

DEFERIPRONE; DEFEROXAMINE; MALONALDEHYDE;

EID: 0029097965     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v86.5.2008.bloodjournal8652008     Document Type: Article
Times cited : (84)

References (28)
  • 1
    • 0003049873 scopus 로고
    • The red cell cycle
    • Brock J, Halliday J, Pippard M, Powell L (eds): Philadelphia, PA, Saunders
    • Brittenham GM: The red cell cycle, in Brock J, Halliday J, Pippard M, Powell L (eds): Iron Metabolism in Health and Disease. Philadelphia, PA, Saunders, 1994, p 31
    • (1994) Iron Metabolism in Health and Disease , pp. 31
    • Brittenham, G.M.1
  • 4
    • 0026690420 scopus 로고
    • Development of iron-chelating agents for clinical use
    • Brittenham GM: Development of iron-chelating agents for clinical use. Blood 80:569, 1992
    • (1992) Blood , vol.80 , pp. 569
    • Brittenham, G.M.1
  • 5
    • 0028406119 scopus 로고
    • Prospects for oral iron chelation therapy
    • Hoffbrand AV: Prospects for oral iron chelation therapy. J Lab Clin Med 123:492, 1994
    • (1994) J Lab Clin Med , vol.123 , pp. 492
    • Hoffbrand, A.V.1
  • 6
    • 0025130087 scopus 로고
    • Long-term trial with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1). II. Clinical observations
    • Bartlett AN, Hoffbrand AV, Kontoghiorghes GJ: Long-term trial with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1). II. Clinical observations. Br J Haematol 76:301, 1990
    • (1990) Br J Haematol , vol.76 , pp. 301
    • Bartlett, A.N.1    Hoffbrand, A.V.2    Kontoghiorghes, G.J.3
  • 8
    • 0027500714 scopus 로고
    • Development of oral iron chelator L1
    • letter
    • Hershko C: Development of oral iron chelator L1. Lancet 341:1088, 1993 (letter)
    • (1993) Lancet , vol.341 , pp. 1088
    • Hershko, C.1
  • 9
    • 0025569762 scopus 로고
    • Design, properties, and effective use of the oral chelator L1 and other α-ketohydroxypyridines in the treatment of transfusional iron overload in thalassemia
    • Kontoghiorghes GJ: Design, properties, and effective use of the oral chelator L1 and other α-ketohydroxypyridines in the treatment of transfusional iron overload in thalassemia. Ann NY Acad Sci 612:339, 1990
    • (1990) Ann NY Acad Sci , vol.612 , pp. 339
    • Kontoghiorghes, G.J.1
  • 10
    • 0000234906 scopus 로고
    • Structure/red blood cell permeability. Activity of iron (III) chelator complexes
    • Kontoghiorghes GJ: Structure/red blood cell permeability. Activity of iron (III) chelator complexes. Inorg Chim Acta 151:101, 1988
    • (1988) Inorg Chim Acta , vol.151 , pp. 101
    • Kontoghiorghes, G.J.1
  • 12
    • 0023781675 scopus 로고
    • Nonheme iron in sickle erythrocyte membranes: Association with phospholipids and potential role in lipid peroxidation
    • Kuross SA, Hebbel RP: Nonheme iron in sickle erythrocyte membranes: Association with phospholipids and potential role in lipid peroxidation. Blood 72:1278, 1988
    • (1988) Blood , vol.72 , pp. 1278
    • Kuross, S.A.1    Hebbel, R.P.2
  • 13
    • 0002426265 scopus 로고
    • Membrane-associated iron
    • Embury SH, Hebbel RP, Mohandas N, Steinberg MH (eds): New York, NY, Raven
    • Hebbel RP: Membrane-associated iron, in Embury SH, Hebbel RP, Mohandas N, Steinberg MH (eds): Sickle Cell Disease: Scientific Principles and Clinical Practice. New York, NY, Raven, 1994, p 163
    • (1994) Sickle Cell Disease: Scientific Principles and Clinical Practice , pp. 163
    • Hebbel, R.P.1
  • 15
    • 0023937376 scopus 로고
    • Excess heme in sickle erythrocyte inside-out membranes. Possible role in thiol oxidation
    • Kuross SA, Rank BH, Hebbel RP: Excess heme in sickle erythrocyte inside-out membranes. Possible role in thiol oxidation. Blood 71:876, 1988
    • (1988) Blood , vol.71 , pp. 876
    • Kuross, S.A.1    Rank, B.H.2    Hebbel, R.P.3
  • 16
  • 17
    • 0025007785 scopus 로고
    • Pharmacokinetic studies in humans with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one
    • Kontoghiorghes GJ, Goddard JG, Bartlett AN, Sheppard L: Pharmacokinetic studies in humans with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one. Clin Pharmacol Ther 48:255, 1990
    • (1990) Clin Pharmacol Ther , vol.48 , pp. 255
    • Kontoghiorghes, G.J.1    Goddard, J.G.2    Bartlett, A.N.3    Sheppard, L.4
  • 18
    • 0023220354 scopus 로고
    • Pharmacokinetics and renal elimination of desferrioxamine and ferrioxamine in healthy subjects and patients with haemochromatosis
    • Allain P, Mauras Y, Chaleil D, Simon P, Ang KS, Cam G, Le Mignon L, Simon M: Pharmacokinetics and renal elimination of desferrioxamine and ferrioxamine in healthy subjects and patients with haemochromatosis. Br J Clin Pharmacol 32:207, 1987
    • (1987) Br J Clin Pharmacol , vol.32 , pp. 207
    • Allain, P.1    Mauras, Y.2    Chaleil, D.3    Simon, P.4    Ang, K.S.5    Cam, G.6    Le Mignon, L.7    Simon, M.8
  • 19
    • 0028345040 scopus 로고
    • Iron-balance and dose-response studies of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in iron-loaded patients with sickle cell disease
    • Collins AF, Fassos FF, Stobie S, Lewis N, Shaw D, Fry M, Templeton DM, McClelland RA, Koren G, Olivieri NF: Iron-balance and dose-response studies of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in iron-loaded patients with sickle cell disease. Blood 83:2329, 1994
    • (1994) Blood , vol.83 , pp. 2329
    • Collins, A.F.1    Fassos, F.F.2    Stobie, S.3    Lewis, N.4    Shaw, D.5    Fry, M.6    Templeton, D.M.7    McClelland, R.A.8    Koren, G.9    Olivieri, N.F.10
  • 23
    • 0026643003 scopus 로고
    • Efficacy and possible adverse effects of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in thalassemia major
    • Al-Refaie FN, Wonke B, Hoffbrand AV, Wickens DG, Nortey P, Kontoghiorghes GJ: Efficacy and possible adverse effects of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in thalassemia major. Blood 80:593, 1992
    • (1992) Blood , vol.80 , pp. 593
    • Al-Refaie, F.N.1    Wonke, B.2    Hoffbrand, A.V.3    Wickens, D.G.4    Nortey, P.5    Kontoghiorghes, G.J.6
  • 24
    • 0026099699 scopus 로고
    • Beyond hemoglobin polymerization: The red blood cell membrane and sickle disease pathophysiology
    • Hebbel RP: Beyond hemoglobin polymerization: The red blood cell membrane and sickle disease pathophysiology. Blood 77:214, 1991
    • (1991) Blood , vol.77 , pp. 214
    • Hebbel, R.P.1
  • 25
    • 0025749683 scopus 로고
    • Hydroxyl radical formation by sickle erythrocyte membranes: Role of pathologic iron deposits and cytoplasmic reducing agents
    • Repka T, Hebbel RP: Hydroxyl radical formation by sickle erythrocyte membranes: Role of pathologic iron deposits and cytoplasmic reducing agents. Blood 78:2753, 1991
    • (1991) Blood , vol.78 , pp. 2753
    • Repka, T.1    Hebbel, R.P.2
  • 26
    • 0017253603 scopus 로고
    • Lipid membrane peroxidation in β-thalassemia major
    • Rachmilewitz EA, Lubin BH, Shohet SB: Lipid membrane peroxidation in β-thalassemia major. Blood 47:495, 1976
    • (1976) Blood , vol.47 , pp. 495
    • Rachmilewitz, E.A.1    Lubin, B.H.2    Shohet, S.B.3
  • 27
    • 0028321696 scopus 로고
    • The oral iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one reduces hepatic-free iron, lipid peroxidation and fat accumulation in chronically ethanol-fed rats
    • Sadrzadeh SMH, Nanji AA, Price PL: The oral iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one reduces hepatic-free iron, lipid peroxidation and fat accumulation in chronically ethanol-fed rats. J Pharmacol Exp Ther 269:632, 1994
    • (1994) J Pharmacol Exp Ther , vol.269 , pp. 632
    • Sadrzadeh, S.M.H.1    Nanji, A.A.2    Price, P.L.3
  • 28
    • 0021702455 scopus 로고
    • The aerobic reduction of Fe(III) complexes by hemoglobin and myoglobin
    • Eguchi LA, Saltman P: The aerobic reduction of Fe(III) complexes by hemoglobin and myoglobin. J Biol Chem 259:14337, 1984
    • (1984) J Biol Chem , vol.259 , pp. 14337
    • Eguchi, L.A.1    Saltman, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.