Mutational analysis of the membrane-proximal cleavage site of l-selectin: Relaxed sequence specificity surrounding the cleavage site

Journal of Experimental Medicine

Volumn 182, Issue 2, 1995, Pages 549-557

  Migaki, Grace I ^a   Kahn, Julius ^a   Kei Kishimoto, Takashi ^a  

^a Boehrlnaer Ingelheim Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

L SELECTIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; DNA CLEAVAGE; GENE DELETION; GENE EXPRESSION REGULATION; GENE LOCATION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANIMAL; CELL ADHESION MOLECULES; COMPARATIVE STUDY; DOWN-REGULATION; ENDOPEPTIDASES; HUMAN; L-SELECTIN; MEMBRANE GLYCOPROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RATS; RECEPTORS, LYMPHOCYTE HOMING; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0029097546     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.182.2.549     Document Type: Article

References (48)

1. Butcher, E.C. 1991. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell. 67: 1033-1036.
2. Springer, T.A. 1990. Adhesion receptors of the immune system. Nature (Lond.). 346: 425-434.
3. Kishimoto, T.K., and R. Rothlein. 1994. Integrins, ICAMs, and selectins: role and regulation of adhesion molecules in neutrophil recruitment to inflammatory sites. In Advances in Pharmacology. F.J. Dixon, editor. Academic Press, New York. 117-169.
4. Dustin, M.L., and T.A. Springer. 1989. T cell receptor crosslinking transiently stimulates adhesiveness through LEA-1. Nature (Lond.). 341: 619-624.
5. Spertini, O., G.S. Kansas, J.M. Munro, J.D. Griffin, and T.F. Tedder. 1991. Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin. Nature (Lond.). 349: 691-694.
6. Todd, R.F., III, M.A. Arnaout, R.E. Rosin, C.A. Crowley, W.A. Peters, and B.M. Babior. 1984. Subcellular localization of the large subunit of Mol (Mol α formerly gp 110), a surface glycoprotein associated with neutrophil adhesion. J. Clin. Invest. 74: 1280-1290.
7. McEver, R.P., J.H. Beckstead, K.L. Moore, C.L. Marshall, and D.F. Bainton. 1989. GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J. Clin. Invest. 84: 92-99.
8. Lasky, L.A. 1992. Selectins: interpreters of cell-specific carbohydrate information during inflammation. Science (Wash. DC). 258: 964-969.
9. Butcher, E.C. 1986. The regulation of lymphocyte traffic. Curr. Topics Microbiol. Immunol. 128: 85-122.
10. Yednock, T.A. and S.D. Rosen. 1989. Lymphocyte homing. Adv. Immunol. 44: 313-378.
11. Lasky, L.A., M.S. Singer, D. Dowbenko, Y. Imai, W.J. Henzel, C. Grimley, C. Fennie, N. Gillett, S.R. Watson, and S.D. Rosen. 1992. An endothelial ligand for Lselectin is a novel mucin-like molecule. Cell. 69: 927-938.
12. Baumhueter, S., N. Dybdal, C. Kyle, and L.A. Lasky. 1994. Global vascular expression of murine CD34, a sialomucin-like endothelial ligand for Lselectin. Blood. 84: 2554-2565.
13. Berg, E.L., M.K. Robinson, R.A. Wamock, and E.C. Butcher. 1991. The human peripheral node addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor. J. Cell Biol. 114: 343-349.
14. Kishimoto, T.K., M.A. Jutila, E.L. Berg, and E.C. Butcher. 1989. Neutrophil Mac-1 and MEL14 adhesion proteins inversely regulated by chemotactic factors. Science (Wash. DC). 245: 1238-1241.
15. Kahn, J., R.H. Ingraham, F. Shirley, G.I. Migaki, and T.K. Kishimoto. 1994. Membrane proximal cleavage of Lselectin: identification of the cleavage site and a 6-kD transmembrane peptide fragment of Lselectin. J. Cell Biol. 125: 461-470.
16. Griffin, J.D., O. Spertini, T.J. Ernst, M.P. Belvin, H.B. Levine, Y. Kanakura, and T.F. Tedder. 1990. Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors. J. Immunol. 145: 576-584.
17. Berg, M., and S.P. James. 1990. Human neutrophils release the Leu-8 lymph node homing receptor during cell activation. Blood. 76: 2381-2388.
18. Bazil, V., and J.L. Strominger. 1994. Metalloprotease and serine protease are involved in cleavage of CD43, CD44, and CD16 from stimulated granulocytes. Induction of cleavage of L-selectin via CD16. J. Immunol. 152: 1314-1322.
19. Johnston, G.I., R.G. Cook, and R.P. McEver. 1989. Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation. Cell. 56: 1033-1044.
20. Bevilacqua, M.P., S. Stengelin, M.A. Gimbrone, and B. Seed. 1989. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science (Wash. DC). 243: 1160-1165.
21. Lasky, L.A., M.S. Singer, T.A. Yednock, D. Dowbenko, C. Fennie, H. Rodriguez, T. Nguyen, S. Stachel, and S.D. Rosen. 1989. Cloning of a lymphocyte homing receptor reveals a lectin domain. Cell. 56: 1045-1055.
22. Siegelman, M.H., M. Van de Rijn, and I.L. Weissman. 1989. Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domains. Science (Wash. DC). 243: 1165-1172.
23. Siegelman, M.H., and I.L. Weissman. 1989. Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains. Proc. Natl. Acad. Sci. USA. 86: 5562-5566.
24. Tedder, T.F., C.M. Isaacs, T.J. Ernst, G.D. Demetri, D.A. Adler, and C.M. Disteche. 1989. Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. J. Exp. Med. 170: 123-133.
25. Camerini, D., S.P. James, I. Stamenkovic, and B. Seed. 1989. Leu-8/TQl is the human equivalent of the Mel-14 lymph node homing receptor. Nature (Lond.). 342: 78-80.
26. Bowen, B.R., T. Nguyen, and L.A. Lasky. 1989. Characterization of a human homologue of the murine peripheral lymph node homing receptor. J. Cell Biol. 109: 421-427.
27. Green, S.A., H. Setiadi, R.P. McEver, and R.B. Kelly. 1994. The cytoplasmic domain of P-selectin contains a sorting determinant that mediates rapid degradation in lysosomes. J. Cell Biol. 124: 435-448.
28. Subramaniam, M., J.A. Koedam, and D.D. Wagner. 1993. Divergent fates of P and E-selectins after their expression on the plasma membrane. Mol. Biol. Celt. 4: 791-801.
29. Schleiffenbaum, B., O. Spertini, andT.F. Tedder. 1992. Soluble L-selectin is present in human plasma at high levels and retains functional activity. J. Cell Biol. 119: 229-238.
30. Jutila, M.A., T.K. Kishimoto, and M. Finken. 1991. Low-dose chymotrypsin treatment inhibits neutrophil migration into sites of inflammation in vivo: effects on Mac-1 and MEL-14 adhesion protein expression and function. Cell. Immunol. 132: 201-214.
31. Gauss, G.H., and M.R. Lieber. 1992. DEAE-dextran enhances electroporation of mammalian cells. Nucleic Acids Res. 20: 6739-6740.
32. Levy, E., M.D. Carman, I.J. Fernandez-Madrid, M.D. Power, I. Lieberburg, S.G. van Duinen, G.A.M. Bots, W. Luyendijk, and B. Frangione. 1990. Mutation of the Alzheimer’s disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science (Wash. DC). 248: 1124-1127.
33. Soubrier, F., F. Alhenc-Gelas, C. Hubert, J. Allegrini, M. John, G. Tregear, and P. Corbol. 1988. Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. Proc Natl. Acad. Sci. USA. 85: 9386-9390.
34. Ravetch, J.V., and B. Perussia. 1989. Alternative membrane forms of Fc RIII (CD16) on human NK cells and neutrophils: cell-type specific expression of two genes which differ in single nucleotide substitutions. J. Exp. Med. 170: 481-497.
35. Kohno, T., M.T. Brewer, S.L. Baker, P.E. Schwartz, M.W. King, K.K. Hale, C.H. Squires, R.C. Thompson, and J.L. Vannice. 1990. A second tumor necrosis factor receptor gene product can shed a natrually occuring tumor necrosis factor inhibitor. Proc. Natl. Acad. Sci. USA. 87: 8331-8335.
36. Barrett, A.J., and G. Salvesen. 1986. Proteinase inhibitors. In Research Monographs in Cell and Tissue Physiology. J.T. Dingle, and J.L. Gordon, editors. Elsevier, Amsterdam. 1-661.
37. Watanabe, T., Y. Song, Y. Hirayama, T. Tamatani, K. Kuida, and M. Miyasaka. 1992. Sequence and expression of a rat cDNA for LECAM-1. Biochim. Biophys. Acta Gene Struct. Express. 1131: 321-324.
38. Pandiella, A., and J. Massague. 1991. Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process. Proc Natl. Acad. Sci. USA. 88: 1726-1730.
39. Pandiella, A., M.W. Bosenberg, E.J. Huang, P. Besmer, and J. Massague. 1992. Cleavage of membrane-anchored growth factors involves distinct protease activities regulated through common mechanisms. J. Biol. Chem. 267: 24028-24033.
40. Wong, S.T., L.F. Winchell, B.K. McCune, H.S. Earp, J. Teixido, J. Massague, B. Herman, and D.C. Lee. 1989. The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction. Cell. 56: 495-505.
41. Perez, C, I. Albert, K. DeFay, N. Zachariades, L. Gooding, and M. Kriegler. 1990. A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact. Cell. 63: 251-258.
42. Sahasrabudhe, S.R., M.A. Spruyt, H.A. Muenkel, A.J. Blume, M.P. Vitek, and J.S. Jacobsen. 1992. Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells. J. Biol. Chem. 267:25602-25608.
43. Sisodia, S.S. 1992. Beta-amyloid precursor protein cleavage by a membrane-bound protease. Proc Natl. Acad. Sci. USA. 89: 6075-6079.
44. Elwood, P.C., J.C. Deutsch, andJ.F. Kolhouse. 1991. The conversion of the human membrane-associated folate-binding protein (folate receptor) to the soluble folate binding protein by a membrane-associated metalloprotease. J. Biol. Chem. 266: 2346-2353.
45. Porteau, F., and C. Nathan. 1990. Shedding of tumor necrosis factor receptors by activted human neutrophils. J. Exp. Med. 172: 599-607.
46. Mullberg, J., H. Schooltink, T. Stoyan, M. Gunther, L. Graeve, G. Buse, A. Mackiewicz, P.C. Heinrich, and S. Rose-John. 1993. The human soluble interleukin-6 receptor is generated by shedding. Eur. J. Immunol. 23: 473-480.
47. Ramchandran, R., G.C. Sen, K. Misono, and I. Sen. 1994. Regulated cleavage-secretion of the membrane-bound angiotensin-converting enzyme. J. Biol. Chem. 269: 2125-2130.
48. Bosenberg, M.W., A. Pandiella, andj. Massague. 1992. The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGFalpha into soluble growth factor. Cell. 71: 1157-1165.