Benzodiazepine-insensitive mice generated by targeted disruption of the γ2 subunit gene of γ-aminobutyric acid type A receptors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 92, Issue 17, 1995, Pages 7749-7753

  Gunther, U ^a   Benson, J ^a   Benke, D ^a   Fritschy, J M ^a   Reyes, G ^a   Knoflach, F ^a   Crestani, F ^a   Aguzzi, A ^a   Arigoni, M ^a   Lang, Y ^a   Bluethmann, H ^a   Mohler, H ^a   Luscher, B ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

assembly of ligand gated ion channels; endogenous benzodiazepines; gene targeting; single channel recording

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE; BENZODIAZEPINE RECEPTOR; BICUCULLINE; DIAZEPAM; DNA; FLUMAZENIL; FLUNITRAZEPAM; ION CHANNEL; PENTOBARBITAL; PICROTOXIN; RECEPTOR SUBTYPE; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BINDING AFFINITY; BINDING SITE; BRAIN DEVELOPMENT; GABAERGIC TRANSMISSION; GENE TARGETING; GROWTH RETARDATION; LIFE EXPECTANCY; LIGAND BINDING; MOTOR DYSFUNCTION; MOUSE; NEWBORN; NONHUMAN; PHENOTYPE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; SENSORY DYSFUNCTION;

ANIMAL; ANIMALS, NEWBORN; ANTI-ANXIETY AGENTS, BENZODIAZEPINE; BASE SEQUENCE; BENZODIAZEPINES; BRAIN; CHIMERA; CROSSES, GENETIC; DNA PRIMERS; EVOKED POTENTIALS; EXONS; FEMALE; GAMMA-AMINOBUTYRIC ACID; GANGLIA, SPINAL; GENOMIC LIBRARY; IMMUNOHISTOCHEMISTRY; IN VITRO; MACROMOLECULAR SYSTEMS; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; NEURONS; PATCH-CLAMP TECHNIQUES; POLYMERASE CHAIN REACTION; RADIOLIGAND ASSAY; RECEPTORS, GABA-A; RESTRICTION MAPPING; SEQUENCE DELETION;

ANIMALIA; TRITIUM;

EID: 0029097465     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.92.17.7749     Document Type: Article

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