Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

Immunity

Volumn 3, Issue 1, 1995, Pages 147-161

  Mackarehtschian, Katrin ^a   Hardin, Jeff D ^b   Moore, Katrd A ^a   Boast, Sharon ^b   Goff, Stephen P ^b   Lemischka, Ihor R ^a  

^a PRINCETON UNIVERSITY   (United States)

^b Department of Biochemistry Molecular Biophysics Columbia University College of Physicians and Surgeons New York ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; INTERLEUKIN 3; INTERLEUKIN 6; PROTEIN TYROSINE KINASE; STEM CELL FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL COUNT; COLONY FORMING UNIT S; CONTROLLED STUDY; GENE DISRUPTION; GENE TARGETING; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LETHALITY; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMAL; B-LYMPHOCYTES; BASE SEQUENCE; CELL DIFFERENTIATION; GENE DELETION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES;

EID: 0029097145     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/1074-7613(95)90167-1     Document Type: Article

References (59)

1. Differential roles of stromal cells, interleukin-7 and kit-Lgand in the regulation of B lymphopoiesis
2. Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages
3. Production and analysis of chimaeric mice
4. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
5. Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles
6. Structure-function studies of a colony stimulating factor (CSF-1)
7. Clonal analysis of primary stroma: functional homogeneity in support of lymphoid and myeloid cell lines and identification of positive and negative regulators
8. Growth and differentiation in the hematopoietic system
9. Conditions controlling the proliferation of hematopoietic stem cells in vitro
10. Characterization of early B lymphocyte precursors present in long-term bone marrow cultures
11. Mitogenic signaling and substrate specificity of the flk2/lt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells
12. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
13. The dominantwhite spotting (W) locus of the mouse encodes the c-kit protooncogene
14. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs
15. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
16. Population of lymphoid tissues in cured W-anemic mice by donor cells
17. v recipients
18. Primitive hematopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations
19. Potentials for lymphoid differentiation by cells from long-term cultures of bones marrow
20. Clonal and systemic analysis of long-term hematopoesis in the mouse
21. Cellular and developmental properties of fetal hematopoietic cells
22. v mice after bone marrow transplantation
23. In vitro proliferation of primitive hemopoietic stem cells supported by stromal cells: evidence for the presence of a mechanism(s) other than that involving c-kit receptor and its ligand
24. Simplified mammalian DNA isolation procedure
25. The haematopoietic stem cell and its clonal progeny: mechanisms regulating the hierarchy of primitive haematopoietic cells
26. Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells
27. Transient nature of early haematopoietic spleen colonies
28. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
29. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
30. Production of single-stranded DNA by asymmetric PCR
31. Giant granules of beige mice: a quantitative marker for granulocytes in bone marrow transplantation
32. Hemopoietic cell growth factors and their receptors
33. Differentiation and proliferation of hematopoietic stem cells
34. Expression and function of c-kit in hemopoietic progenitor cells
35. Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule
36. In vivo and in vitro stem cell function of c-kitand Sca-1-positive murine hematopoietic cells
37. Developmentally regulated cell surface expression and function of c-kit receptor during lymphocyte ontogeny in the embryo and adult mice
38. Fetal liver pro-B and pre-B lymphocyte clones: expression of lymphoid-specific genes, surface markers, growth requirements, colonization of the bone marrow, and generation of B lymphocytes in vivo and in vitro
39. Flow cytometry and fluorescence activated cell sorting (FAGS)
40. Separation of CFU-S from primitive cells responsible for reconstitution of the bone marrow hematopoietic stem cell compartment following irradiation: evidence for a pre-CFU-S cell
41. Embryo-derived stem cell lines
42. Germline transmission of genes introduced into cultured pluripotent cells by retroviral vector
43. The c-kit-encoded tyrosine kinase regulates the proliferation of early pre-B cells
44. Murine FIt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family
45. Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells
46. Hereditary anemias of the mouse: a review for geneticists
47. In vitro studies on lymphocyte differentiation. I. Long term in vitro culture of cells giving rise to functional lymphocytes in irradiated mice
48. + human bone marrow cells and is involved in the proliferation of early progenitor/stem cells
49. Clonal analysis of hematopoietic stem-cell differentiation in vivo
50. Purification and characterization of mouse hematopoietic stem cells
51. Factors regulating macrophage production and growth: purification and some properties of the colony stimulating factor from medium conditioned by mouse L cells
52. A direct measurement of radiation sensitivity of normal mouse bone marrow cells
53. Isolation of murine pluripotent stem cells
54. Long-term culture of B lymphocytes and their precursors from murine bone marrow
55. Inhibition of hematopoietic development from embryonic stem cells by antisense vav RNA
56. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
57. Cellular and molecular characterization of the role of the flk-2/ flt-3 receptor tyrosine kinase in hematopoietic stem cells
58. Hematopoietic development of vav-/- mouse embryonic stem cells