The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis

Gastroenterology

Volumn 109, Issue 3, 1995, Pages 994-998

  Pasricha, Pankaj Jay ^a   Bedi, Atul ^a   O'Connor, Kathryn ^a   Rashid, Asif ^a   Akhtar, Adil J ^a   Zahurak, Marianna L ^a   Piantadosi, Steven ^a   Hamilton, Stanley R ^a   Giardiello, Francis M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; SULINDAC;

ADENOMATOUS POLYP; ADULT; APOPTOSIS; ARTICLE; CELL CYCLE; CELL KINETICS; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL TRIAL; COLON MUCOSA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRYPT CELL; DNA SYNTHESIS; DOUBLE BLIND PROCEDURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0029088472     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/0016-5085(95)90411-5     Document Type: Article

References (23)

1. Non-steroidal antiinflammatory agents in chemoprevention of colorectal cancer—at what cost?
2. Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis
3. Sulindac for polyposis of the colon
4. Sulindac causes regression of rectal polyps in familial adenomatous polyposis
5. Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis
6. Rectal proliferation and polyp occurrence in patients with familial adenomatous polyposis after sulindac treatment.
7. Correlations between rectal mucosa cell proliferation and the clinical and pathological features of familial neoplasia of the large bowel
8. Kinetics of normal, preneoplastic, and neoplastic colonic epithelium
9. Features of apoptotic cells measured by flow cytometry
10. The relationship of proliferative defects to colorectal cancer
11. Apoptosis and disease
12. Proliferative patterns in colonic mucosa in familial polyposis
13. Study of human rectal epithelial cells in vitro
14. Phase one and phase two proliferative lesions of colonic epithelial cells in diseases leading to colonic cancer
15. Significance of the labeling index and labeling distribution as kinetic parameters in colorectal mucosa of cancer patients and DMH treated animals
16. bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis
17. Inhibition of apoptosis during development of colorectal cancer
18. p53-dependent apoptosis suppresses tumor growth and progression in vivo
19. The use of indomethacin, sulindac and tamoxifen for the treatment of desmoid tumors associated with familial polyposis
20. Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine
21. Effect of indomethacin in autotransplanted colonic tumors
22. Antiproliferative activity of antiinflammatory drugs on two mammalian cell clones
23. Cell proliferation in colorectal tumor progression: an immunohistochemical approach to intermediate biomarkers