Relationships of generalized and regional adiposity to insulin sensitivity in men

Journal of Clinical Investigation

Volumn 96, Issue 1, 1995, Pages 88-98

  Abate, Nicola ^a,b   Garg, Abhimanyu ^a,b   Peshock, Ronald M ^b   Stray Gundersen, James ^a   Grundy, Scott M ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

fat distribution; insulin resistance; magnetic resonance imaging; obesity; skinfolds

Indexed keywords

ANTHROPOMETRY; ARTICLE; BODY FAT; DIABETES MELLITUS; HUMAN; INSULIN SENSITIVITY; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PRIORITY JOURNAL; RISK FACTOR;

EID: 0029087640     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118083     Document Type: Article

References (73)

1. Manson, J. E., G. A. Colditz, M. J. Stampfer, W. C. Willett, B. Rosner, R. R. Monson, F. E. Speizer, and C. H. Hennekens. 1990. A prospective study of obesity and risk of coronary heart disease in women. N. Engl. J. Med. 322:882-889.
2. Hubert, H. B., M. Fenileib, P. M. McNamara, and W. P. Castelli. 1983. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham heart study. Circulation. 67:968-977.
3. Chapman, J. M., A. H. Coulson, V. A. Clark, and E. R. Borun. 1971. The differential effect of serum cholesterol, blood pressure and weight on the incidence of myocardial infarction and angina pectoris. J. Chronic Dis. 23:631-645.
4. van Itallie, T. B. 1985. Health implications of overweight and obesity in the United States. Ann. Intern. Med. 103:983-988.
5. Knowler, W. C., D. J. Pettitt, P. J. Savage, and P. H. Bennett. 1981. Diabetes incidence in Pima indians: contributions of obesity and parental diabetes. Am. J. Epidemiol. 113:144-156.
6. Westlund, K., and R. Nicolaysen. 1972. Ten-year mortality and morbidity related to serum cholesterol. A follow-up of 3,751 men aged 40-49. Scand. J. Clin. Lab. Invest. 127(Suppl. X):1-24.
7. Haffner, S. M., M. P. Stern, B. D. Mitchell, H. P. Hazuda, and J. K. Patterson. 1990. Incidence of type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity, and body-fat distribution. Diabetes. 39:283-288.
8. Zavaroni, I., E. Bonora, M. Pagliara, E. Dall'Aglio, L. Luchetti, G. Buonanno, P. A. Bonati, M. Bergonzani, L. Gnudi, M. Passeri, and G. M. Reaven. 1989. Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N. Engl. J. Med. 320:702-706.
9. Ferrannini, E., S. M. Haffner, B. D. Mitchell, and M. P. Stern. 1991. Hyperinsulinemia: the key feature of a cardiovascular and metabolic syndrome. Diabetologia. 34:416-422.
10. Vague, J. 1956. The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. Am. J. Clin. Nutr. 4:20-34.
11. Kissebah, A. H., N. Vydelingum, R. Murray, P. J. Evans, A. J. Hartz, R. K. Kalkhoff, and P. W. Adams. 1982. Relation of body fat distribution to metabolic complications of obesity. J. Clin. Endocrinol. & Metab. 54:254-260.
12. Krotkiewski, M., P. Bjorntorp, L. Sjostrom, and U. Smith. 1983. Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J. Clin. Invest. 72:1150-1162.
13. Evans, D. J., R. G. Hoffmann, R. K. Kalkhoff, and A. H. Kissebah. 1984. Relationship of body fat topography to insulin sensitivity and metabolic profiles in premenopausal women. Metab. Clin. Exp. 33:68-75.
14. Hartz, A. J., D. C. Rupley, and A. A. Rimm. 1984. The association of girth measurements with disease in 32,856 women. Am. J. Epidemiol 119:71-80.
15. Larsson, B., J. Seidell, K. Svardsudd, L. Welin, G. Tibblin, L. Wilhelmsen, and P. Bjorntorp. 1989. Obesity, adipose tissue distribution and health in men - the study of men born in 1913. Appetite. 13:37-44.
16. Despres, J. P., S. Moorjani, M. Ferland, A. Tremblay, P. J. Lupien, A. Nadeau, S. Pinault, G. Theriault, and C. Bouchard. 1989. Adipose tissue distribution and plasma lipoprotein levels in obese women. Importance of intra-abdominal fat. Arteriosclerosis. 9:203-210.
17. Haffner, S. M., M. P. Stern, H. P. Hazuda, J. Pugh, and J. K. Patterson. 1987. Do upper-body and centralized adiposity measure different aspects of regional body-fat distribution? Relationship to non-insulin-dependent diabetes mellitus, lipids, and lipoproteins. Diabetes. 36:43-51.
18. Lapidus, L., C. Bengtsson, B. Larsson, K. Pennert, E. Rybo, and L. Sjostrom. 1984. Distribution of adipose tissue and risk of cardiovascular disease and death: a 12-year follow-up of participants in the population study of women in Gothenburg. Br. Med. J. 289:1257-1261.
19. Ohlson, L. O., B. Larsson, K. Svardsudd, L. Welin, H. Eriksson, L. Wilhelmsen, P. Bjomtorp, and G. Tibblin. 1985. The influence of body fat distribution on the incidence of diabetes mellitus. 13.5 years of follow-up of the participants in the study of men born in 1913. Diabetes. 34:1055-1058.
20. Ducimetiere, P., J. Richard, and F. Cambien. 1986. The pattern of subcutaneous fat distribution in middle-aged men and the risk of coronary heart disease: the Paris Prospective Study. Int. J. Obes. 10:229-240.
21. Casassus, P., A. Fontbonne, N. Thibult, P. Ducimetiere, J. L. Richard, J. R. Claude, J. M. Warnet, G. Rosselin, and E. Eschwege. 1992. Upper-body fat distribution: a hyperinsulinemia-independent predictor of coronary heart disease mortality. The Paris Prospective Study. Anterioscler. Thromb. 12:1387-1392.
22. Donahue, R. P., R. D. Abbott, E. Bloom, D. M. Reed, and K. Yano. 1987. Central obesity and coronary heart disease in men. Lancet. 1:821-824.
23. Welin, L., K. Svardsudd, L. Wilhelmsen, B. Larsson, and G. Tibblin. 1987. Analysis of risk factors for stroke in a cohort of men born in 1913. N. Engl. J. Med. 317:521-526.
24. Carlson, L. A., D. Hallberg, and H. Micheli. 1969. Quantitative studies on the lipolytic response of human subcutaneous and omental adipose tissue to noradrenaline and theophylline. Acta Med. Scand. 185:465-469.
25. Richelsen, B., S. B. Pedersen, T. Moller-Pedersen, and J. F. Bak. 1991. Regional differences in triglyceride breakdown in human adipose tissue: effects of catecholamines, insulin, and prostaglandin E2. Metab. Clin. Exp. 40:990-996.
26. Landin, K., P. Lonnroth. M. Krotkiewski, G. Holm, and U. Smith. 1990. Increased insulin resistance and fat cell lipolysis in obese but not lean women with high waist/hip ratio. Eur. J. Clin. Invest. 20:530-535.
27. Rebuffe-Scrive, M., L. Enk, N. Crona, P. Lonnroth, L. Abrahamsson, U. Smith, and P. Bjorntorp. 1985. Fat cell metabolism in different regions in women. Effects of menstrual cycle, pregnancy, and lactation. J. Clin. Invest. 75:1973-1976.
28. Ostman, J., P. Arner, P. Engfeldt, and L. Kager. 1979. Regional differences in the control of lipolysis in human adipose tissue. Metab. Clin. Exp. 28:1198-1205.
29. Efendic, S. 1970. Catecholamines and metabolism of human adipose tissue. III. Comparison between the regulation of lipolysis in omental and subcutaneous adipose tissue. Acta Med. Scand. 187:477-483.
30. Lafontan, M., L. Dong-Tran, and M. Berlan. 1979. Alpha-adrenergic antilipolytic effect of adrenaline in human fat cells of the thigh: comparison with adrenaline responsiveness of different fat deposits. Eur. J. Clin. Invest. 9:261-266.
31. Bjorntorp, P. 1990. "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis. 10:493-496.
32. Abate, N., D. Burns, R. M. Peshock, A. Garg, and S. M. Grundy. 1994. Estimation of adipose tissue mass by magnetic resonance imaging: validation against dissection in human cadavers. J. Lipid Res. 35:1490-1496.
33. Siri, W. E. 1961. Body composition from fluid spaces and density. In Techniques for Measuring Body Composition. J. Brozek and A. Hanschel, editors. National Academy of Sciences, Washington, DC. 223-224.
34. Thomas, L. W. 1962. The chemical composition of adipose tissue of man and mice. Q. J. Exp. Physiol. 47:179-188.
35. DeFronzo, R. A., J. D. Tobin, and R. Andres. 1979. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 233:E214-E223.
36. Finegood, D. T., R. N. Bergman, and M. Vranic. 1987. Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates. Diabetes. 36:914-924.
37. Steele, R. 1959. Influence of glucose loading and of injected insulin on hepatic glucose output. Ann. NY Acad. Sci. 82:420-430.
38. Insel, P. A, J. E. Liljenquist, J. D. Tobin, R. S. Shewin, P. Watkins, R. Andres, and M. Berman. 1975. Insulin control of glucose metabolism in man: a new kinetic analysis. J. Clin. Invest. 55:1057-1066.
39. Meneilly, G. S., D. Elahi, K. L. Minaker, and J. W. Rowe. 1987. Somatostatin does not alter insulin-mediated glucose disposal. J. Clin. Endocrinol. & Metab. 65:364-370.
40. Herbert, V., K. Lau, C. W. Gottlieb, and S. J. Bleicher. 1965. Coated charcoal immunoassay of insulin. J. Clin. Endocrinol. & Metab. 25:1375-1384.
41. Yalow, R. S., and S. A. Berson. 1960. Immunoassay of endogenous plasma insulin in man. J. Clin. Invest. 39:1157-1175.
42. The Lipid Research Clinics Population Studies Data Book. 1979. Volume 1: The Prevalence study. U.S. Department of Health, Education, and Welfare; Public Health Service; National Institute of Health. Publication No. 79-1527.
43. National Diabetes Data Group. 1979. Classification and diagnosis of diabetes mellitus and other categories of glucose tolerance. Diabetes. 28:1039-1057.
44. Randle, P. J., P. B. Garland, C. N. Hales, and E. A. Newsholme. 1963. The glucose-fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1:785-789.
45. Ferrannini, E., E. J. Barrett, S. Bevilacqua, and R. A. DeFronzo. 1983. Effect of fatty acids on glucose production and utilization in man. J. Clin. Invest. 72:1737-1747.
46. Crespin, S. R., W. B. Greenough III, and D. Steinberg. 1973. Stimulation of insulin secretion by long-chain free fatty acids: a direct pancreatic effect. J. Clin. Invest. 52:1979-1984.
47. Svedberg, J., G. Stromblad, A. Wirth, U. Smith, and P. Bjomtorp. 1991. Fatty acids in the portal vein of the rat regulate hepatic insulin clearance. J. Clin. Invest. 88:2054-2058.
48. Opie, L. H., and P. G. Walfish. 1963. Plasma free fatty acid concentration in obesity. N. Engl. J. Med. 268:757-760.
49. Golay, A., J. P. Felber, H. U. Meyer, B. Curchod, E. Maeder, and E. Jequier. 1984. Study on lipid metabolism in obesity diabetes. Metab. Clin. Exp. 33:111-116.
50. Golay, A., A. L. Swislocki, Y. D. Chen, J. B. Jaspan, and G. M. Reaven. 1986. Effect of obesity on ambient plasma glucose, free fatty acid, insulin, growth hormone, and glucagon concentrations. J. Clin. Endocrinol. & Metab. 63:481-484.
51. Dole, V. P. 1956. The relations between nonesterified fatty acids in plasma and the metabolism of glucose. J. Clin. Invest. 35:150-154.
52. Gordon, T., and W. B. Kammell. 1973. The effects of overweight on cardiovascular diseases. Geriatrics. 28:80-88.
53. Bjorntorp, P. 1985. Obesity and the risk of cardiovascular disease. Ann. Clin. Res. 17:3-9.
54. Bouchard, C., J. P. Despres, and P. Mauriege. 1993. Genetic and nongenetic determinants of regional fat distribution. Endocr. Rev. 14:72-93.
55. Jensen, M. D., M. W. Haymond, R. A. Rizza, P. E. Cryer, and J. M. Miles. 1989. Influence of body fat distribution on free fatty acid metabolism in obesity. J. Clin. Invest. 83:1168-1173.
56. van der Kooy, K., R. Leenen, J. C. Seidell, P. Deurenberg, A. Droop, and C. J. G. Bakker. 1993. Waist-hip ratio is a poor predictor of changes in visceral fat. Am. J. Clin. Nutr. 57:327-333.
57. Sparrow, D., G. A. Borkan, S. G. Gerzof, C. Wisniewski, and C. K. Silbert. 1986. Relationship of fat distribution to glucose tolerance. Results of computed tomography in male participants of the Normative Aging Study. Diabetes. 35:411-415.
58. Fujioka, S., Y. Matsuzawa, K. Tokunaga, and S. Tarui. 1987. Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metab. Clin. Exp. 36:54-59.
59. Koester, R. S., G. R. Hunter, S. Snyder, M. A. Khaled, and L. L. Berland. 1992. Estimation of computerized tomography derived abdominal fat distribution. Int. J. Obes. 16:543-554.
60. Marin, P., B. Andersson, M. Ottosson, L. Olbe, B. Chowdhury, H. Kvist, G. Holm, L. Sjostrom, and P. Bjontorp. 1992. The morphology and metabolism of intraabdominal adipose tissue in men. Metab. Clin. Exp. 41:1242-1248.
61. Chowdhury, B., L. Sjostrom, M. Alpsten, J. Kostanty, H. Kvist, and R. Lofgren. 1994. A multicompartment body composition technique based on computerized tomography. Int. J. Obes. 18:219-234.
62. Ross, R., K. D. Shaw, J. Rissanen, Y. Martel, J. de Guise, and L. Avruch. 1994. Sex differences in lean and adipose tissue distribution by magnetic resonance imaging: anthropometric relationships. Am. J. Clin. Nutr. 59:1277-1285.
63. Bogardus, C., S. Lillioja, D. Mott, G. R. Reaven, A. Kashiwagi, and J. E. Foley. 1984. Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in Pima Indians. J. Clin. Invest. 73:800-805.
64. Bogardus, C., S. Lillioja, D. M. Mott, C. Hollenbeck, and G. M. Reaven. 1985. Relationship between degree of obesity and in vivo insulin action in man. Am. J. Physiol. 248:E286-E289.
65. Kohrt, W. M., J. P. Kirwan, M. A. Staten, R. E. Bourey, D. S. King, and J. O. Holloszy. 1993. Insulin resistance in aging is related to abdominal obesity. Diabetes. 42:273-281.
66. Evans, D. J., R. Murray, and A. H. Kissebah. 1984. Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography. J. Clin. Invest. 74:1515-1525.
67. Landin, K., P. Lonnroth, M. Krotkiewski, G. Holm, and U. Smith. 1990. Increased insulin resistance and fat cell lipolysis in obese but not lean women with a high waist/hip ratio. Eur. J. Clin. Invest. 20:530-535.
68. Sato, Y., A. Iguchi, and N. Sakamoto. 1984. Biochemical determination of training effects using insulin clamp technique. Horm. Metab. Res. 16:483-486.
69. Bogardus, C., E. Ravussin, D. C. Robbins, R. R. Wolfe, E. S. Horton, and E. A. Sims. 1984. Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus. Diabetes. 33:311-318.
70. Lillioja, S., D. M. Mott, J. K. Zawadzki, A. A. Young, W. G. Abbott, W. C. Knowler, P. H. Bennett, P. Moll, and C. Bogardus. 1987. In vivo insulin action is a familial characteristic in nondiabetic Pima Indians. Diabetes. 36:1329-1335.
71. Rebuffe-Scrive, M., B. Andersson, L. Olbe, and P. Bjomtorp. 1989. Metabolism of adipose tissue in intraabdominal depots of nonobese men and women. Metab. Clin. Exp. 38:453-458.
72. Rebuffe-Scrive, M., B. Anderson, L. Olbe, and P. Bjomtorp. 1990. Metabolism of adipose tissue in intraabdominal depots in severely obese men and women. Metab. Clin. Exp. 39:1021-1025.
73. Despres, J. P., S. Moorjani, P. J. Lupian, A. Tremblay, A. Nadeau, and C. Bouchard. 1990. Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis. 10:497-511.