MDL 100,458 and MDL 102,288: two potent and selective glycine receptor antagonists with different functional profiles

European Journal of Pharmacology

Volumn 284, Issue 1-2, 1995, Pages 109-118

  Kehne, John H ^a   Baron, Bruce M ^a   Harrison, Boyd L ^a   McCloskey, Timothy C ^a   Palfreyman, Michael G ^a   Poirot, Matthieu ^b   Salituro, Francesco G ^a   Siegel, Barry W ^a   Slone, Amy L ^a   Van Giersbergen, Paul L M ^b   White, H Steven ^c  

^a Merrell Dow Research Institute   (United States)

^b SANOFI   (France)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

(DBA 2J mouse); (Rat pup); Anticonvulsant; Anxiolytic; Audiogenic seizure; Glycine receptor, strychnine insensitive; NMDA receptor; Separation induced vocalization

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 (5 METHYL 1H IMIDAZOL 4 YL) 1 (1 METHYL 1H INDOL 3 YL) 1 PROPANONE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID RECEPTOR BLOCKING AGENT; ATROPINE; DIHYDROALPRENOLOL; FLUNITRAZEPAM; GLYCINE; GLYCINE RECEPTOR; GLYCINE RECEPTOR ANTAGONIST; HALOPERIDOL; KETANSERIN; MDL 100458; MDL 102288; MDL 72222EF; MEPYRAMINE; MESULERGINE; METHYLSCOPOLAMINE; MIANSERIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NALOXONE; NITRENDIPINE; PARGYLINE; PHENTOLAMINE; PINDOLOL; PRAZOSIN; PROMETHAZINE; RADIOLIGAND; RAUWOLSCINE; SPIPERONE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; AUDIOGENIC SEIZURE; BEHAVIOR; BRAIN; BRAIN CORTEX; BRAIN SLICE; CEREBELLUM; CONTROLLED STUDY; HIPPOCAMPUS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; TRANQUILIZING ACTIVITY; ULTRASONIC VOCALIZATION; ULTRASOUND; VOCALIZATION;

ACOUSTIC STIMULATION; ANIMAL; ANIMALS, NEWBORN; ANXIETY, SEPARATION; BINDING, COMPETITIVE; BRAIN; GLYCINE; GLYCINE AGENTS; INDOLES; MICE; MICE, INBRED DBA; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DRUG; RECEPTORS, GLUTAMATE; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE; SEIZURES; VOCALIZATION, ANIMAL;

EID: 0029087437     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00375-U     Document Type: Article

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