The role of free radicals and p53 in neuron apoptosis in vivo

Journal of Neuroscience

Volumn 15, Issue 8, 1995, Pages 5851-5857

  Wood, Katherine A ^a   Youle, Richard J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

apoptosis; cerebellum; free radicals; methylazoxymethanol; p53; x irradiation

Indexed keywords

DNA FRAGMENT; FREE RADICAL; METHYLAZOXYMETHANOL; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CEREBELLUM; CONTROLLED STUDY; GAMMA IRRADIATION; GENOTOXICITY; GRANULE CELL; IONIZING RADIATION; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0029086989     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.15-08-05851.1995     Document Type: Article

References (41)

1. Altman J (1972) Postnatal development of the cerebellar cortex in the rat. J Comp Neurol 145:353-398.
2. Altman J, Anderson WJ (1972) Experimental reorganization of the cerebellar cortex. I. Morphological effects of elimination of all microneurons with prolonged X-irradiation started at birth. J Comp Neurol 146:355-406.
3. Bejar A, Roujansky P, Barry JD, Gombos G (1985) Different effects of methylazoxymethanol on mouse cerebellar development depending on the age of injection. Exp Brain Res 57:279-285.
4. Biegel JA, Burk CD, Barr FG, Emanuel BS (1992) Evidence for a 17p tumor related locus distinct from p53 in pediatric primitive neuroectodermal tumors. Cancer Res 52:3391-3395.
5. Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Turka T, Mao LA, Nunez G, Thompson CB (1993) bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597-608.
6. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, Wyllie AH (1993) Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 392:849-851.
7. Cogen PH, Daneshvar L, Metzger AK, Duyk G, Edwards MSB, Sheffield VC (1992) Involvement of multiple chromosome 17p loci in medulloblastoma tumorigenesis. Am J Hum Genet 50:584-589.
8. Dipasquale B, Marini AM, Youle RJ (1991) Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons. Biochem Biophys Res Commun 181:1442-1448.
9. D'Mello S, Galli C, Ciotti MT, Calissano P (1993) Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc Natl Acad Sci USA 90:10989-10993.
10. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery J, Butel JS, Bradley A (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356:215-221.
11. Ferrer I, Serrano T, Alcantara S, Tortosa A, Graus F (1993) X-ray-induced cell death in the developing hippocampal complex involves neurons and requires protein synthesis. J Neuropathol Exp Neurol 52: 370-378.
12. Garcia-Ladona FJ, Barry JD, Girard C, Gombos G (1991) Ectopic granule cell layer in mouse cerebellum after methyl-azoxy-methanol (MAM) treatment. Exp Brain Res 86:90-96.
13. Harmon BV, Allan DJ (1988) X-ray-induced death by apoptosis in the immature rat cerebellum. Scan Microscopy 2:561-568.
14. Hockenbery DM, Zutter M, Mickey W, Nahm M, Korsmeyer SJ (1991) Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 88:6961-6965.
15. Hockenbery DM, Oltvai ZN, Yin X-M. Milliman CL, Korsmeyer SJ (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75:241-251.
16. Inouye M, Kameyama Y (1983) Cell death in the developing rat cerebellum following X-irradiation of 3 to 100 rad: a quantitative study. J Radiat Res 24:259-269.
17. Inouye M, Tamarus M, Kameyama Y (1992) Effects of cycloheximide and actinomycin D on radiation-induced apoptotic cell death in the developing mouse cerebellum. Int J Radiat Biol 61:669-674.
18. Ito M (1984) The cerebellum and neural control. New York: Raven.
19. Jones M, Yang M, Mickelsen O (1972) Effects of methazoxymethanol acetate and methylazoxymethanol glucoside on the cerebellum of postnatal Swiss albino mouse. Fed Proc 31:1508-1511.
20. Kastan MB, Onyekewere O, Sidransky D, Vogelstein B, Harris CC (1991) Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51:6304-6311.
21. Kastan MB, Zhan Q, EI-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Albert J. Fornace J (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in Ataxia-Telangiectasia. Cell 71:587-597.
22. Kemp CJ, Donehower LA, Bradley A, Balmain A (1993) Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 74:813-822.
23. Kuhar SG, Feng L, Vidan S, Ross ME, Hatten ME, Heintz N (1993) Changing patterns of gene expression define four stages of cerebellar granule neuron differentiation. Development 117:97-104.
24. Landis DMD, Sidman (1978) Electron microscopic analysis of postnatal histogenesis in the cerebellar cortex of staggerer mutant mice. J Comp Neurol 179.
25. Lange W (1975) Cell number and cell density in the cerebellar cortex of man and some other mammals. Cell Tissue Res 157:115-124.
26. Lowe SW, Ruley HE, Jacks T, Housman DE (1993a) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74: 957-967.
27. Lowe SW, Schmitt EM, Smith SW Osborne BA, Jacks T (1993b) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362:847-849.
28. Mares V, Lodin Z (1970) The cellular kinetics of the developing mouse cerebellum. II. The function of the external granular layer in the process of gyrification. Brain Res 23:343-352.
29. Matsumoto H, Higa HH (1966) Studies on methylazoxymethanol, the aglycone of cycasin: methylation of nucleic acids in vitro. Biochem J 98:20c-22c.
30. Merritt AJ, Potten CS, Kemp CJ, Hickman JA, Balmain A, Lane DP, Hall PA (1994) The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res 54:614-617.
31. Merry DE, Veis DJ, Hickey WF, Korsemeyer SJ (1994) bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS. Development 120:301-311.
32. Miyashita T, Harigai M, Hanada M, Reed JC (1994a) Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res 54:3131-3135.
33. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffman B, Reed JC (1994b) Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9:1799-1805.
34. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog. Bax, that accelerates programed cell death. Cell 74:609-619.
35. 2+: their relationship to apoptosis and oncogenesis. FEBS Lett 325:104-107.
36. Rorke LB (1983) The cerebellar medulloblastoma and its relationship to primitive neuroectodermal tumors. J Neuropathol Exp Neurol 42: 1-15.
37. Sambrook J, Fritsch EF, Manialis T (1987) Molecular cloning: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
38. Saylors RL, Sidransky D, Friedman HS, Bigner SH, Bigner DD, Vogelstein B, Brodeur GM (1991) Infrequent p53 mutations in medulloblastomas. Cancer Res 51:4721-4723.
39. Slagel DE, Feola J, Houchens DP, Ovejera AA (1982) Combined modality treatment using radiation and/or chemotherapy in an athymic nude mouse-human medulloblastoma and glioblastoma xenograft mode. Cancer Res 42:812-816.
40. Wood KA, Dipasquale B, Youle RJ (1993) In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum. Neuron 11:621-632.
41. Van G-M, Ni B, Weller M, Wood KA, Paul SM (1994) Depolarization blocks apoptosis of cerebellar neurons. Brain Res 656:43-51.