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Volumn 60, Issue 3, 1995, Pages 264-270

Rapamycin, a potent immunosuppressive drug, causes programmed cell death in В lymphoma cells

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; DNA FRAGMENT; DRUG BINDING PROTEIN; IMMUNOGLOBULIN M ANTIBODY; RAPAMYCIN; TACROLIMUS; THYMIDINE; TRITIUM; TSUKUBAENOLIDE BINDING PROTEIN; UNCLASSIFIED DRUG; URIDINE;

EID: 0029086748     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199508000-00010     Document Type: Article
Times cited : (134)

References (60)
  • 1
    • 0016713286 scopus 로고
    • Rapamycin (AY 22, 989), a new anti-fungal antibiotic II. Fermentation, isolation and characterization
    • Sehgal SN, Baker H, Vezina C. Rapamycin (AY 22, 989), a new anti-fungal antibiotic II. Fermentation, isolation and characterization. J Antibiot 1975; 28: 727.
    • (1975) J Antibiot , vol.28 , pp. 727
    • Sehgal, S.N.1    Baker, H.2    Vezina, C.3
  • 2
    • 0017362502 scopus 로고
    • Inhibition of the immune response by rapamycin, a new antifungal antibiotic
    • Martel RR, Klicius J, Galet S. Inhibition of the immune response by rapamycin, a new antifungal antibiotic. Can J Physiol Pharmacol 1977; 55: 48.
    • (1977) Can J Physiol Pharmacol , vol.55 , pp. 48
    • Martel, R.R.1    Klicius, J.2    Galet, S.3
  • 3
    • 85025352713 scopus 로고
    • Rapamycins: Antifungal, anti-tumor, anti-prolifera tive and immunosuppressive molecules
    • Morris RE. Rapamycins: antifungal, anti-tumor, anti-prolifera tive and immunosuppressive molecules. Transplant Rev 1992; 6: 39.
    • (1992) Transplant Rev , vol.6 , pp. 39
    • Morris, R.E.1
  • 4
    • 0026748870 scopus 로고
    • Cyclosporin A, FK 506 and rapamycin: Pharmacologic probes of lymphocyte signal transduction
    • Sigal NH, Dumont FJ. Cyclosporin A, FK 506 and rapamycin: pharmacologic probes of lymphocyte signal transduction. Annu Rev Immunol 1992; 10: 519.
    • (1992) Annu Rev Immunol , vol.10 , pp. 519
    • Sigal, N.H.1    Dumont, F.J.2
  • 5
    • 0024976525 scopus 로고
    • Rapamycin for immunosup pression in organ allografting
    • Caine RY, Collier D, Lim S, et al. Rapamycin for immunosup pression in organ allografting. Lancet 1989; 2: 227.
    • (1989) Lancet , vol.2 , pp. 227
    • Caine, R.Y.1    Collier, D.2    Lim, S.3
  • 6
    • 0024345850 scopus 로고
    • Identification of a new pharmacologic action for an old compound [Letter]
    • Morris RE, Meiser BM. Identification of a new pharmacologic action for an old compound [Letter], Med Sci Res 1989; 17: 609.
    • (1989) Med Sci Res , vol.17 , pp. 609
    • Morris, R.E.1    Meiser, B.M.2
  • 7
    • 0026024078 scopus 로고
    • Rapamycin, a potent immunosuppressive drug for vascularized heart, kidney, and small bowl transplantation in the rat
    • Stepkowski SM, Chen H, Daloze P, Kahn BD. Rapamycin, a potent immunosuppressive drug for vascularized heart, kidney, and small bowl transplantation in the rat. Transplantation 1991; 51: 22.
    • (1991) Transplantation , vol.51 , pp. 22
    • Stepkowski, S.M.1    Chen, H.2    Daloze, P.3    Kahn, B.D.4
  • 8
    • 0026554258 scopus 로고
    • Inhibi tion of host-versus-graft and graft-versus host responses after small bowel transplantation in rats by rapamycin
    • Stepkowski SM, Chen H, Wang M, Daloze P, Kahn BD. Inhibi tion of host-versus-graft and graft-versus host responses after small bowel transplantation in rats by rapamycin. Transplantation 1992; 53: 28.
    • (1992) Transplantation , vol.53 , pp. 28
    • Stepkowski, S.M.1    Chen, H.2    Wang, M.3    Daloze, P.4    Kahn, B.D.5
  • 9
    • 0027383477 scopus 로고
    • Reversal of ongoing heart, kidney, and pancreas allograft rejection and suppression of accelerated heart allograft rejection in the rat by rapamycin
    • Chen H, Wu J, Xu D, Luo H, Daloze P. Reversal of ongoing heart, kidney, and pancreas allograft rejection and suppression of accelerated heart allograft rejection in the rat by rapamycin. Transplantation 1993; 56: 661.
    • (1993) Transplantation , vol.56 , pp. 661
    • Chen, H.1    Wu, J.2    Xu, D.3    Luo, H.4    Daloze, P.5
  • 10
    • 0026075058 scopus 로고
    • The immunosuppressive effect of rapamycin on pancreaticoduodenal transplants in the rat
    • Chen H, Wu JP, Luo H, Daloze P. The immunosuppressive effect of rapamycin on pancreaticoduodenal transplants in the rat. Transplant Proc 1991; 23: 2239.
    • (1991) Transplant Proc , vol.23 , pp. 2239
    • Chen, H.1    Wu, J.P.2    Luo, H.3    Daloze, P.4
  • 11
    • 0026661361 scopus 로고
    • Synergistic effect of rapamycin and cyclosporine in pancreaticoduodenal transplantation in the rat
    • Chen H, Wu J, Luo H, Daloze P. Synergistic effect of rapamycin and cyclosporine in pancreaticoduodenal transplantation in the rat. Transplant Proc 1992; 24: 892.
    • (1992) Transplant Proc , vol.24 , pp. 892
    • Chen, H.1    Wu, J.2    Luo, H.3    Daloze, P.4
  • 12
    • 0026704769 scopus 로고
    • The effect of rapamycin on orthotopic small bowel transplantation in the rat
    • Chen H, Wu J, Xu D, et al. The effect of rapamycin on orthotopic small bowel transplantation in the rat. Transplant Proc 1992; 24: 1157.
    • (1992) Transplant Proc , vol.24 , pp. 1157
    • Chen, H.1    Wu, J.2    Xu, D.3
  • 13
    • 0023917532 scopus 로고
    • Studies on FK506 in experimental organ transplantation
    • Ochiai T, Sakamoto K, Nagata M, et al. Studies on FK506 in experimental organ transplantation. Transplant Proc 1988; 20: 209.
    • (1988) Transplant Proc , vol.20 , pp. 209
    • Ochiai, T.1    Sakamoto, K.2    Nagata, M.3
  • 14
    • 0023899755 scopus 로고
    • FK506 in experimental renal allografts in dogs and primates
    • Collier DStJ, Calney RY, Thiru S, et al. FK506 in experimental renal allografts in dogs and primates. Transplant Proc 1988; 20: 226.
    • (1988) Transplant Proc , vol.20 , pp. 226
    • St. Collier, D.J.1    Calney, R.Y.2    Thiru, S.3
  • 16
    • 0019537187 scopus 로고
    • Lymphoma in renal allograft patients treated with cyclosporin A as one of the immunosuppressive agents
    • Thiru S, Caine RY, Nagington J. Lymphoma in renal allograft patients treated with cyclosporin A as one of the immunosuppressive agents. Transplant Proc 1981; 13: 359.
    • (1981) Transplant Proc , vol.13 , pp. 359
    • Thiru, S.1    Caine, R.Y.2    Nagington, J.3
  • 17
    • 0021344743 scopus 로고
    • Monoclonality of lymphoprolif-erative lesions in cardiac-transplant recipients. Clonal analysis based on immunoglobulin-gene rearrangement
    • Cleary ML, Wamke R, Sklar J. Monoclonality of lymphoprolif-erative lesions in cardiac-transplant recipients. Clonal analysis based on immunoglobulin-gene rearrangement. N Engl J Med 1984; 310: 477.
    • (1984) N Engl J Med , vol.310 , pp. 477
    • Cleary, M.L.1    Wamke, R.2    Sklar, J.3
  • 18
    • 0023130690 scopus 로고
    • Cancers following cyclosporine therapy
    • Penn I. Cancers following cyclosporine therapy. Transplantation 1987; 43: 32.
    • (1987) Transplantation , vol.43 , pp. 32
    • Penn, I.1
  • 21
    • 0026759874 scopus 로고
    • Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
    • Price DJ, Grove JR, Calvo V, Avruch J, Bierer BE. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science 1992; 257: 973.
    • (1992) Science , vol.257 , pp. 973
    • Price, D.J.1    Grove, J.R.2    Calvo, V.3    Avruch, J.4    Bierer, B.E.5
  • 22
    • 0028328655 scopus 로고
    • Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin like growth factor receptor
    • Dilling MB, Dias P, Shapiro DN, Germain GS, Johnson RK, Houghton PJ. Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin like growth factor receptor. Cancer Res 1994; 54: 903.
    • (1994) Cancer Res , vol.54 , pp. 903
    • Dilling, M.B.1    Dias, P.2    Shapiro, D.N.3    Germain, G.S.4    Johnson, R.K.5    Houghton, P.J.6
  • 23
    • 0021164348 scopus 로고
    • Activity of rapamycin (AY-22, 989) against transplanted tumors
    • Eng CP, Sehgal SN, Vizina C. Activity of rapamycin (AY-22, 989) against transplanted tumors. J Antibiot 1984; 37: 1231.
    • (1984) J Antibiot , vol.37 , pp. 1231
    • Eng, C.P.1    Sehgal, S.N.2    Vizina, C.3
  • 24
    • 0024472603 scopus 로고
    • A receptor for immunosuppressant FK506 is a cis-trans peptidyl prolyl isomerase
    • Harding M, Galat A, Uehling D, Schrieber SL. A receptor for immunosuppressant FK506 is a cis-trans peptidyl prolyl isomerase. Nature 1989; 341: 758.
    • (1989) Nature , vol.341 , pp. 758
    • Harding, M.1    Galat, A.2    Uehling, D.3    Schrieber, S.L.4
  • 25
    • 0024442393 scopus 로고
    • A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin
    • Siekerka J, Hung S, Poe M, Lin C, Sigal N. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature 1989; 341: 755.
    • (1989) Nature , vol.341 , pp. 755
    • Siekerka, J.1    Hung, S.2    Poe, M.3    Lin, C.4    Sigal, N.5
  • 26
    • 0025647885 scopus 로고
    • Two distinct signal transduction pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin
    • Bierer BE, Mattila PS, Standaert RF, et al. Two distinct signal transduction pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc Natl Acad Sci USA 1990; 87: 9231.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9231
    • Bierer, B.E.1    Mattila, P.S.2    Standaert, R.F.3
  • 28
    • 0025099697 scopus 로고
    • Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK506 and rapamycin
    • Dumont FJ, Staruch MJ, Koprak SC, Melino MR, Sigal NH. Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK506 and rapamycin. J Immunol 1990; 144: 251.
    • (1990) J Immunol , vol.144 , pp. 251
    • Dumont, F.J.1    Staruch, M.J.2    Koprak, S.C.3    Melino, M.R.4    Sigal, N.H.5
  • 29
    • 0024412228 scopus 로고
    • The immunosuppres sant FK506 selectively inhibits expression of early T cell activation genes
    • Tocci MJ, Matkovich DA, Collier KA, et al. The immunosuppres sant FK506 selectively inhibits expression of early T cell activation genes. J Immunol 1989; 143: 718.
    • (1989) J Immunol , vol.143 , pp. 718
    • Tocci, M.J.1    Matkovich, D.A.2    Collier, K.A.3
  • 30
    • 0026090594 scopus 로고
    • FK506 and CSA inhibit highly similar signal transduction pathways in human T lymphocytes
    • Lin CS, Boltz RC, Siekierka JJ, Sigal NH. FK506 and CSA inhibit highly similar signal transduction pathways in human T lymphocytes. Cell Immunol 1991; 133: 269.
    • (1991) Cell Immunol , vol.133 , pp. 269
    • Lin, C.S.1    Boltz, R.C.2    Siekierka, J.J.3    Sigal, N.H.4
  • 31
    • 0026030568 scopus 로고
    • Chemistry and biology of the immunophilins and their immunosuppressive ligands
    • Schrieber SL. Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 1991; 251: 283.
    • (1991) Science , vol.251 , pp. 283
    • Schrieber, S.L.1
  • 32
    • 0025893168 scopus 로고
    • Calcinuerin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schrieber SL. Calcinuerin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 1991; 66: 807.
    • (1991) Cell , vol.66 , pp. 807
    • Liu, J.1    Farmer, J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schrieber, S.L.6
  • 33
    • 0025871394 scopus 로고
    • Nuclear translocation of a T cell transcription factor blocked by FK506 and cyclosporin A
    • Flanagan WM, Corthesy B, Bram RJ, Crabtree GR. Nuclear translocation of a T cell transcription factor blocked by FK506 and cyclosporin A. Nature 1991; 352: 803.
    • (1991) Nature , vol.352 , pp. 803
    • Flanagan, W.M.1    Corthesy, B.2    Bram, R.J.3    Crabtree, G.R.4
  • 34
    • 0026659046 scopus 로고
    • Rapamycin-FKBP specifically blocks growth dependent activation of and signaling by the 70 kd S6 protein kinases
    • Chung J, Kuo CJ, Crabtree GR, Blenis J. Rapamycin-FKBP specifically blocks growth dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 1992; 69: 1227.
    • (1992) Cell , vol.69 , pp. 1227
    • Chung, J.1    Kuo, C.J.2    Crabtree, G.R.3    Blenis, J.4
  • 36
    • 0026666050 scopus 로고
    • Interleukin-2 stimula tion of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin
    • Calvo V, Crews CM, Vik TA, Bierer BE. Interleukin-2 stimula tion of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin. Proc Natl Acad Sci USA 1992; 89: 7571.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7571
    • Calvo, V.1    Crews, C.M.2    Vik, T.A.3    Bierer, B.E.4
  • 37
    • 0027231244 scopus 로고
    • Failure of rapamycin to block proliferation once resting cells have entered the cell cycle, despite inactivation of p70 S6 kinase
    • Terada N, Franklin RA, Lucas JJ, Blenis J, Gelfand EW. Failure of rapamycin to block proliferation once resting cells have entered the cell cycle, despite inactivation of p70 S6 kinase. J Biol Chem 1993; 268: 12062.
    • (1993) J Biol Chem , vol.268
    • Terada, N.1    Franklin, R.A.2    Lucas, J.J.3    Blenis, J.4    Gelfand, E.W.5
  • 39
    • 0027510985 scopus 로고
    • Rapamycin blocks cell cycle progression of activated T cell prior to events characteristic of the middle to late G1 phase of the cycle
    • Terada N, Lucas JJ, Szepesi A, Franklin RA, Domenico J, Gel fand EW. Rapamycin blocks cell cycle progression of activated T cell prior to events characteristic of the middle to late G1 phase of the cycle. J Cell Physiol 1993; 154: 7.
    • (1993) J Cell Physiol , vol.154 , pp. 7
    • Terada, N.1    Lucas, J.J.2    Szepesi, A.3    Franklin, R.A.4    Domenico, J.5    Gel fand, E.W.6
  • 41
    • 0026048328 scopus 로고
    • Cyclosporin A blocks surface IgM mediated growth inhibition in an immature B lymphoma, BKS-2
    • Udhayakumar V, Muthukkumar S, Subbarao B. Cyclosporin A blocks surface IgM mediated growth inhibition in an immature B lymphoma, BKS-2. Eur J Immunol 1991; 21: 2605.
    • (1991) Eur J Immunol , vol.21 , pp. 2605
    • Udhayakumar, V.1    Muthukkumar, S.2    Subbarao, B.3
  • 42
    • 0027360451 scopus 로고
    • Elevation of cytosolic calcium is sufficient to induce growth inhibition in a B cell lymphoma
    • Muthukkumar S, Udhayakumar V, Bondada S. Elevation of cytosolic calcium is sufficient to induce growth inhibition in a B cell lymphoma. Eur J Immunol 1993; 23: 2419.
    • (1993) Eur J Immunol , vol.23 , pp. 2419
    • Muthukkumar, S.1    Udhayakumar, V.2    Bondada, S.3
  • 44
    • 0021165662 scopus 로고
    • Transformation-associ ated proteins in murine B cell lymphomas that are distinct from Abelson virus gene products
    • Pillemer E, Whitlock C, Weissman IL. Transformation-associ ated proteins in murine B cell lymphomas that are distinct from Abelson virus gene products. Proc Natl Acad Sci USA 1984; 81: 4434.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 4434
    • Pillemer, E.1    Whitlock, C.2    Weissman, I.L.3
  • 45
    • 0021966190 scopus 로고
    • Monoclonal antibodies for murine IgM. II. Activation of B cells by monoclonal antibodies specific for the four constant domains of IgM
    • Leptin M. Monoclonal antibodies for murine IgM. II. Activation of B cells by monoclonal antibodies specific for the four constant domains of IgM. Eur J Immunol 1985; 15: 131.
    • (1985) Eur J Immunol , vol.15 , pp. 131
    • Leptin, M.1
  • 46
    • 0026007124 scopus 로고
    • The influence of avidity on signaling murine B lymphocytes with monoclonal anti-IgM antibodies. Effects on B cell proliferation versus growth inhibition (tolerance) of an immature B cell lymphoma
    • Udhayakumar V, Kumar L, Subbarao B. The influence of avidity on signaling murine B lymphocytes with monoclonal anti-IgM antibodies. Effects on B cell proliferation versus growth inhibition (tolerance) of an immature B cell lymphoma. J Immunol 1991; 146: 4120.
    • (1991) J Immunol , vol.146 , pp. 4120
    • Udhayakumar, V.1    Kumar, L.2    Subbarao, B.3
  • 47
    • 0004265596 scopus 로고
    • New York: Greene Publishing Associates and Wiley-Interscience, 2. 2
    • Strauss WM. Current protocols in molecular biology. New York: Greene Publishing Associates and Wiley-Interscience, 1987: 2. 2. 1.
    • (1987) Current protocols in molecular biology , pp. 1
    • Strauss, W.M.1
  • 48
    • 0025022365 scopus 로고
    • The immunosuppressive macrolides FK506 and rapamycin act as reciprocal antagonists in murine T cells
    • Dumont FJ, Melino MR, Staruch MJ, Koprak SL, Fischer PA, Sigal NH. The immunosuppressive macrolides FK506 and rapamycin act as reciprocal antagonists in murine T cells. J Immunol 1990; 144: 1418.
    • (1990) J Immunol , vol.144 , pp. 1418
    • Dumont, F.J.1    Melino, M.R.2    Staruch, M.J.3    Koprak, S.L.4    Fischer, P.A.5    Sigal, N.H.6
  • 49
    • 0020977755 scopus 로고
    • Cellular mechanisms of immunological tolerance
    • Nossal GJV. Cellular mechanisms of immunological tolerance. Annu Rev Immunol 1983; 1: 33.
    • (1983) Annu Rev Immunol , vol.1 , pp. 33
    • Nossal, G.J.V.1
  • 54
    • 0019394338 scopus 로고
    • Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast
    • Nurse P, Bissett Y. Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast. Nature 1981; 292: 558.
    • (1981) Nature , vol.292 , pp. 558
    • Nurse, P.1    Bissett, Y.2
  • 56
    • 0025967749 scopus 로고
    • cdc2 phosphorylation and histone HI kinase activity is associated with Gl/S phase growth arrest
    • cdc2 phosphorylation and histone HI kinase activity is associated with Gl/S phase growth arrest. Mol Cell Biol 1991; 11: 1185.
    • (1991) Mol Cell Biol , vol.11 , pp. 1185
    • Howe, P.H.1    Draetta, G.2    Leof, E.B.3
  • 57
    • 0025033793 scopus 로고
    • Cell cycle control in eukaryotes: Molecular mecha nisms of cdc-2 activation
    • Draetta G. Cell cycle control in eukaryotes: molecular mecha nisms of cdc-2 activation. Trends Biol Sci 1990; 15: 378.
    • (1990) Trends Biol Sci , vol.15 , pp. 378
    • Draetta, G.1
  • 58
    • 0024521441 scopus 로고
    • Bcl2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
    • McDonnel TJ, Deane N, Platt FM, et al. bcl2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 1989; 57: 79.
    • (1989) Cell , vol.57 , pp. 79
    • McDonnel, T.J.1    Deane, N.2    Platt, F.M.3
  • 59
    • 0023786047 scopus 로고
    • Bcl2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
    • Vaux DL, Cory S, Adams JM. bcl2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1988; 335: 440.
    • (1988) Nature , vol.335 , pp. 440
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3


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