Benzodiazepines for depression? A review of the literature

International Clinical Psychopharmacology

Volumn 10, Issue 3, 1995, Pages 181-195

  Birkenhager T K ^a   Moleman, P ^b   Nolen, W A ^c  

^a Psychiatric Centre Bloemendaal   (Netherlands)

^b Amerongen the Netherlands   (Netherlands)

^c H C Rumke Group   (Netherlands)

Author keywords

Classical benzodiazepines; Major depression; Minor depression; Symptom response; Triazolo benzodiazepines; Tricyclic antidepressants

Indexed keywords

ADINAZOLAM; ALPRAZOLAM; AMITRIPTYLINE; BENZODIAZEPINE; BROMAZEPAM; CHLORDIAZEPOXIDE; CLOMIPRAMINE; DESIPRAMINE; DIAZEPAM; DOSULEPIN; DOXEPIN; IMIPRAMINE; OXAZEPAM; PRAZEPAM; PROTRIPTYLINE; TRICYCLIC ANTIDEPRESSANT AGENT;

ANXIETY; DEPRESSION; HUMAN; PRIORITY JOURNAL; REVIEW; SLEEP;

BENZODIAZEPINES; DEPRESSIVE DISORDER; HUMAN; PLACEBO EFFECT; STATISTICS; TREATMENT OUTCOME;

EID: 0029086446     PISSN: 02681315     EISSN: 14735857     Source Type: Journal    
DOI: 10.1097/00004850-199510030-00008     Document Type: Article

References (78)

1. Amori G and Lenox RH (1989) Do volunteer subjects bias clinical trials? Journal of Clinical Psychopharmacology, 9. 321-327.
2. Amsterdam JD, Kaplan M, Potter L, Bloom L and Rickels K (1986) Adinazolam, a new triazolo-benzodiazepine, and lmipramine in the treatment of major depressive disorder. Psychopharmacology, 88, 484-488.
3. Angst J, Bech P, Boyer P., Bruinvels J, Engel R., Helmchen H, Hippius H, Lingjaerde O, Racagni G, Saletu B, Sedvall G, Silverstone T, Stefanis CN, Stoll K and Woggon B (1989) Consensus conference on the methodology of clinical trials of antidepressants. Zurich, March 1988: report of the consensus committee. Pharmacopsychiatry, 22, 3-7.
4. Ansseau M (1992) The Atlantic gap: clinical trials in Europe and the United States. Biological Psychiatry, 31, 109-111.
5. Ansseau M., Ansoms C., Beckers G., Bogaerts M, Botte L., DeBuck R, Diricq S, Dumortier A, Jansegers E, Owieczka J and Stellamans G (1984) Double-blind study comparing alprazolam anddoxepin in primary unipolar depression. Journal of Affective Disorders, 7, 287-296.
6. Ansseau M, Devoitille JM., Papart P, Vanbrabant E, Mantanus H and Timsit M (1991) Comparison of adinazolam. amitriptyline and diazepam in endogenous depressive inpatients exhibiting DST nonsuppression or abnormal contigent negative variation. Journal of Clinical Psychopharmacology, 11. 160-165.
7. Beaubien J, Ban TA, Lehman HE and Jarrold L (1970) Doxepin in the treatment of psychoneurotic patients. Current Therapeutic Research, 12, 192-194.
8. Bech P, Gram LF, Dein E., Jacobsen O, Vitger J and Bolwig TG (1975) Quantitative rating of depressive states. Acta Psychi- atrica Scandinavica, 51. 161-170.
9. Borison RL, Sinha D, Ahlbrecht JW, Geber S and Diamond BI (1989) Double-blind comparison of 3 and 6 mg fixed doses of alprazolam vs. placebo in outpatients with major depressive disorder. Psychopharmacology Bulletin, 25, 186-189.
10. Bowen RC (1978) The effect of diazepam on the recovery of endogenously depressed patients. Journal of Clinical Pharmacology, 18, 280-284.
11. Claghorn J and Kellner R (1971) When is a tranquillizer an antidepressant? Current Therapeutic Research, 13, 575-579.
12. Cloninger CR, Martin RL, Guze SB and Clayton P (1990) The empirical structure of psychiatric comorbidity and its theoretical significance. In: Comorbidity of Mood and Anxiety Disorders (Eds JD Maser and CR Cloninger), pp. 439-462. American Psychiatric Press, Washington, DC.
13. Cohen LS and Rosenbaum JF (1987) Clonazepam: new uses and potential problems. Journal of Clinical Psychiatry, 48 (suppl 10), 50-55.
14. Cohn JB., Pyke RE and Wilcox CS (1988) Adinazolam mesylate and placebo in depressed outpatients: a 6-week, double-blind comparison. Journal of Clinical Psychiatry, 49. 142-147.
15. Covi L, Lipman RS., Derogalis LR., Smith JE and Pattison JH (1974) Drugs and group psychotherapy in neurotic depression. American Journal of Psychiatry. 131, 191-198.
16. D’Elia G., von Knorring L., Marcusson J, Mattson R., Perris C and Persson G (1974) A double-blind comparison between doxepin and diazepam in the treatment of states of anxiety. Acta Psychiatrica Scandinavica, 75, 35-46.
17. Dunner D, Myers J, Khan A, Avery D, Ishiki D and Pyke R (1987) Adinazolam—a new antidepressant: findings of a placebo-controlled, double-blind study in outpatients with major depression. Journal of Clinical Psychopharmacology, 7, 170-172.
18. Eisenberg L (1992) Treating depression and anxiety in primary care. Closing the gap between knowledge and practice. New England Journal of Medicine, 326, 1080-1084.
19. Eriksson B, Nagy A, Starmark JE and Thelander U (1987) Alprazolam compared to amitriptyline in the treatment of major depression. Acta Psychiatrica Scandinavica, 750, 656-663.
20. Fawcett J and Kravitz HM (1985) Treatment refractory depression. In: Common Treatment Problems in Depression (Ed. AF Schatzberg), pp. 2-27. American Psychiatric Press, Washington, DC.
21. Fawcett J, Edwards JH, Kravitz HM and Jeffries H (1987) Alprazolam: an antidepressant? Alprazolam, desipramine and an alprazolam-desipramine combination in the treatment of adull depressed outpatients. Journal of Clinical Psychopharmacology, 7, 295-310.
22. Feet PO, Larsen S and Robak OH (1985) A double-blind study in outpatients with primairy non-agitated depression treated with imipramine in combination with placebo, diazepam or dixyra- zine. Acta Psychiatrica Scandinavica, 72, 334-340.
23. Feighner JP., Brauzer B, Gelenberg AJ, Gomez E, Kiev A, Kurland ML and Weiss BL (1979) A placebo-controlled multicenter trial of Limbitrol versus its components in the symptomatic treatment of depressive illness. Psychopharmacology, 61, 217-225.
24. Feighner JP., Aden GC, Fabre LE, Rickels K and Smith WT Comparison of alprazolam, imipramine and placebo in the treatment of depression. Journal of the American Medical Association, 249, 3057-3064.
25. Frances A, Manning D, Marin D, Kocsis J, McKinney K, Hall W and Kline M (1992) Relationship of anxiety and depression. Psychopharmacology, 106, S82-S86.
26. Goldberg SC, Ettigi P, Schulz PM, Hamer RM, Hayes PE and Friedel RO (1986) Alprazolam versus imipramine in depressed outpatients with neurovegetative signs. Journal of Affective Disorders, 11, 139-145.
27. Grunhaus L (1988) Clinical and psychobiological characteristics of simultaneous panic disorder and major depression. American Journal of Psychiatry, 145, 1214-1221.
28. Hare HP (1971) Comparison of chlordiazepoxide-amitiptyline combination with amitriptyline alone in anxiety-depressive states. Journal of Clinical Pharmacology, 11, 456-460.
29. Hicks F., Robins E and Murphy GE (1988) Comparison of adinazolam, amitriptyline and placebo in the treatment of melancholic depression. Psychiatry Research, 23, 221-227.
30. Hubain PP., Castro P, Mesters P, de Martelaer V and Mendlewicz J (1990) Alprazolam and amitriptyline in the treatment of major depressive disorder: a double-blind clinical and sleep EEG study. Journal of Affective Disorders, 18, 67-73.
31. Imlah NW (1985) An evaluation of alprazolam in the treatment of reactive or neurotic depression. British Journal of Psychiatry, 146, 515-519.
32. Jacobson F (1978) Doctor-patient concordance in a placebo- controlled trial of Limbitrol versus its components. Psychopharmacology Bulletin, 14. 61-62.
33. Johnson DAW (1979) A double-blind comparison of flupentixol. nortriptyline and diazepam in neurotic depression. Acta Psychiatrica Scandinavica, 59, 1-8.
34. Johnson DAW (1985) The use of benzodiazepines in depression. British Journal of Clinical Pharmacology, 19. 31S-35S.
35. Johnson F, Sacco FA and Yellowley T (1973) Chlordiazepoxide and dothiepin compared in anxiety/depression in general practice. The Practitioner, 211, 362-364.
36. Johnstone EC, Cunningham Owens DG, Frith CD., McPherson R., Dowie C, Riley G and Gold A (1980) Neurotic illness and its response to anxiolytic and antidepressant treatment. Psychological Medicine, 10, 321-328.
37. Johnstone EE and Claghorn JL (1968) Doxepin vs. chlordiazepoxide: a controlled comparison in neurotic outpatients. Current Therapeutic Research, 10, 514-519.
38. Kay DWK, Fahy T and Gorside RF (1970) A seven month double-blind trial of amitriptyline and diazepam in ECT- treated patients. British Journal of Psychiatry, 117. 667-671.
39. Kennedy SH, De Groot J, Ralevsky E and Reed K (1991) A comparison of adinazolam and desipramine in the treatment of major depression. International Clinical Psychopharmacology, 6, 65-76.
40. Lapierre YD., Browne M, Oyewumi K and Sarantidis D (1994) Alprazolam and amitriptyline in the treatment of moderate depression. International Clinical Psychopharmacology, 9, 41-45
41. Laus D, Ashford JJ and Anster JA (1990) A multi-centre doubleblind comparative trial of fluvoxamine versus lorazepam in mixed anxiety and depression treated in general practice. Acta Psychiatrica Scandinavica. 81, 185-189.
42. Lemoine P, Boulenger JP., Caillard V, Tanne N and Bonnet D (1991) Compared efficacy of prazepam and clomipramine in major depression with anxiety: a multicenter controlled study. Pharmacopsychiatry, 24. 175-179.
43. Lenox RH, Shipley JE, Peyser JM, Williams M and Weaver LA (1984) Double-blind comparison of alprazolam versus imipramine in the treatment of major depressive illness. Psychopharmacology Bulletin, 20, 79-82.
44. Lipman RS, Covi L, Rickels K, McNair DM, Downing R, Kahn RJ, Lassiter VK and Faden V (1986) Imipramine and chlordiazepoxide in depressive and anxiety disorders. Archives of General Psychiatry, 43, 68-77.
45. Lydiard RB, Laraia MT, Ballenger JC and Howell EF (1987) Emergence of depressive symptoms in patients receiving alprazolam for panic disorder. American Journal of Psychiatry, 144, 664-665.
46. Mendels J and Schless AP (1986) Comparative efficacy of alprazolam, imipramine and placebo administered once a day in treating depressed patients. Journal of Clinical Psychiatry, 47, 357-361.
47. Montgomery BA, Cullinan TR and Bayley AJ (1970) A doubleblind comparative trial of doxepin hydrochloride and chlordiazepoxide in anxiety and depression in general practice. British Journal of Clinical Practice, 24, 207-209.
48. Nolen WA and Haffmans J (1989) Treatment of resistant depression. International Clinical Psychopharmacology, 4, 217-228.
49. Overall JE, Biggs J, Jacobs M and Holden K (1987) Comparison of alprazolam and imipramine for the treatment of outpatient depression. Journal of Clinical Psychiatry, 48, 15-19.
50. Paykel ES (1989) Treatment of depression. The relevance of research for clinical practice. British Journal of Psychiatry, 155. 754-763.
51. Paykel ES, Hollyman JA, Freeling P and Sedgwick P (1988) Predictors of therapeutic benefit from amitriptyline in mild depression: a general practice placebo-controlled trial. Journal of Affective Disorders, 14, 83-95.
52. Quitkin FM (1985) The importance of dosage in prescribing antidepressants. British Journal of Psychiatry, 147, 593-597.
53. Quitkin FM, Rabkin JG, Ross D and McGrath PJ (1984) Duration of antidepressant drug treatment. What is an adequate trial? Archives of General Psychiatry, 41, 238-245.
54. Rabkin JG, McGrath PJ., Quitkin FM., Tricamo E, Stewart JW and Klein DF (1990) Effects of pill-giving on the maintenance of placebo response in patients with chronic mild depression. American Journal of Psychiatry, 147, 1622-1626.
55. Remick RA, Fleming JAE, Buchanan RA, Keller FD, Hamilton P., Loomer F and Miles JE (1985) A comparison of the safety and efficacy of alprazolam and desipramine in moderately severe depression. Canadian Journal of Psychiatry, 30. 597-601.
56. Remick RA., Keller FD., Buchanan RA, Gibson RE and Fleming JAE (1988) A comparison of the efficacy and safety of alprazolam and desipramine in depressed outpatients. Canadian Journal of Psychiatry, 33, 590-594.
57. Rickels K., Perloff M., Stepansky W, Dion HS, Case WG and Sapra RK (1969) Doxepin and diazepam in general practice and hospital clinic neurotic patients: a collaborative controlled study. Psychopharmacology, 15, 265-279.
58. Rickels K, Hesbacher P and Downing RW (1970) Differential drug effects in neurotic depression. Diseases of the Nervous System, 31, 468-475.
59. Rickels K, Feighner JP and Smith WT (1985) Alprazolam, amitriptyline and placebo in the treatment of depression. Archives of General Psychiatry, 42, 134-141.
60. Rickels K., Chung HR., Csanalosi IB., Hurowitz AM., London J, Wiseman K, Kaplan M and Amsterdam JD (1987) Alprazolam, diazepam, imipramine and placebo in outpatients with major depression. Archives of General Psychiatry, 44. 862-866.
61. Rickels K, London J, Fox I, Hassman H, Csanalosi I and Weise C (1991) Adinazolam, diazepam, imipramine and placebo in major depressive disorder: a controlled study. Pharmacopsychiatry, 24, 127-131.
62. Robinson DS and Kuntz NM (1990) Relationships between anxiety and depression affecting development of antidepressant and antianxiety drugs. In: Comorbidity of Mood and Anxiety Disorders (Eds JD Maser and CR Cloninger), pp. 693-706. American Psychiatric Press, Washington, DC.
63. Rush AJ, Erman MK, Schlesser MA, Roffwarg HP, Vasavada N., Khatami M, Fairchild C and Giles DE (1985) Alprazolam vs. amitriptyline in depressions with reduced REM-latencies. Archives of General Psychiatry, 42, 1154-1159.
64. Ryan HF, Merill B and Scott GE (1968) Increasing in suicidal thoughts and tendencies: association with diazepam therapy. Journal of the American Medical Association, 203, 1137-1139.
65. Schatzberg AF and Cole JO (1978) Benzodiazepines in depressive disorders. Archives of General Psychiatry, 35, 1359-1365.
66. Shammas E (1977) Controlled comparison of bromazepam. amitriptyline and placebo in anxiety depressive neurosis. Diseases of the Nervous System, 38, 201-207.
67. Sim M, Bindman E, Conochie BC and Sandilands DWIM (1971) A comparative trial of doxepin with chlordiazepoxide. Clinical Trials Journal, 8. 22-21.
68. Singh AN, Nair NPV, Surany-Cadotte B., Schwartz G and Lizondo E (1988) A double-blind comparison of alprazolam and amitriptyline hydrochloride in the treatment of non-psy- chotic depression. Canadian Journal of Psychiatry, 33. 218-222.
69. Smith WT and Glaudin V (1986) Double-blind efficacy and safety study comparing adinazolam mesylate and placebo in depressed inpatients. Acta Psychiatrica Scandinavica, 74. 238-245.
70. Sterlin C, Ban TA, Lehmann HE and Jarrold L (1970) A comparative evaluation of doxepin and chlordiazepoxide in the treatment of psychoneurotic outpatients. Current Therapeutic Research, 12, 195-200.
71. Sterlin C, Ban TA and Jarrold L (1972) The place of doxepin among the anxiolytic-sedative drugs. Current Therapeutic Research, 14, 195-204.
72. Stewart JW, Quitkin FM., Liebowitz MR., McGrath PJ, Harrison WM and Klein DF (1983) Efficacy of desipramine in depressed outpatients: response according to research diagnostic criteria diagnosis and severity of illness. Archives of General Psychiatry, 40, 202-207.
73. Thase ME, Hersen M, Beliak AS, Himmelhoeh JM and Kupfer DJ (1983) Validation of a Hamilton subscale for endogenomorfic depression. Journal of Affective Disorders. 5, 267-278.
74. Tiller J., Schweitzer I, Maguire K and Davies B (1989) Is diazepam an antidepressant? British Journal of Psychiatry, 155. 483-489.
75. van den Brink W., Leenstra A., Ormel J and van de Willige G (1991) Mental health intervention programs in primary care: their scientific basis. Journal of Affective Disorders, 21, 273-284.
76. Verner JV (1969) Comparison of imipramine and chlordiazepoxide in the treatment of the depressed and anxious patient. Journal of the Florida Medical Association. 56, 15-21.
77. Weissman MM, Prusoff B, Sholomskas AJ and Greenwald S A double-blind clinical trial of alprazolam, imipramine or placebo in the depressed elderly. Journal of Clinical Psychopharmacology. 12. 175-182.
78. Wheatley D (1971) General Practitioner Clinical Trials: the antidepressant effects of tranquillizers. The Practitioner, 206, 146-148.