Modeling and optimization of populations subject to time-dependent mutation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 92, Issue 18, 1995, Pages 8219-8223

  Kepler, Thomas B ^a   Perelson, Alan S ^b  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

affinity maturation; optimal control; somatic hypermutation; stochastic model

Indexed keywords

ARTICLE; CELL GROWTH; CELL PROLIFERATION; DOWN REGULATION; GENE MUTATION; GENE REPLICATION; GENETIC REGULATION; IMMUNE RESPONSE; MODEL; MUTATION RATE; POPULATION RESEARCH; PRIORITY JOURNAL; RECEPTOR AFFINITY; SOMATIC MUTATION; STOCHASTIC MODEL;

B-LYMPHOCYTES; GENETICS, POPULATION; MODELS, GENETIC; MONTE CARLO METHOD; MUTATION; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0029086332     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.92.18.8219     Document Type: Article

References (30)