The effect of long term caffeine treatment on hypoxic-ischemic brain damage in the neonate

Pediatric Research

Volumn 38, Issue 3, 1995, Pages 312-318

  Bona, Elsa ^a   Ådén, Ulrika ^b   Fredholm, Bertil B ^b   Hagberg, Henrik ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; CAFFEINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; ANIMALS, NEWBORN; BRAIN; BRAIN ISCHEMIA; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; FEMALE; HYPOXIA, BRAIN; MATERNAL EXPOSURE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P1; SUPPORT, NON-U.S. GOV'T; XANTHINES;

EID: 0029085969     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/00006450-199509000-00007     Document Type: Article

References (49)

1. Watkinson B, Fried PA 1985 Maternal caffeine use before, during and after pregnancy and effects upon offspring. Neurobehav Toxicol Teratol 7:9-17
2. Aranda JV, Turmen T 1979 Methylxanthines in apnea of prematurity. Clin Perinatol 6:87-108
3. Maikel R, Snodgrass W 1973 Physicochemical factors in maternal-fetal distribution of drugs. Toxic Appl Pharmacol 26:218-230
4. Ikeda GJ, Sapienza PP, McGinnis ML, Bragg LE, Walsh JJ, Collins TXF 1982 Blood level of caffeine and results of fetal examination after oral administration of caffeine to pregnant rats. J Appl Toxicol 2:307-314
5. Ryu JE 1985 Caffeine in human milk and in serum of breast fed infants. Dev Pharmacol Ther 8:329-337
6. Fredholm BB, Sollevi A 1986 Cardiovascular effects of adenosine. J Clin Physiol 6:1-21
7. Neims A, vonBorstel RW 1983 Caffeine: Metabolism and biochemical mechanisms of action. Nutr Brain 6:1-30
8. Arnaud ML 1987 The pharmacology of caffeine. Progr Drug Res 31:273-313
9. Berthou F, Ratansavanh D, Riche C, Picart D, Voirin T, Guillouzo A 1989 Compar¬ison of caffeine metabolism by slices, microsomes and hepatocyte cultures from adult human liver. Xenobiotica 19:401-417
10. Aldrige A, Aranda JV, Neims AH 1979 Caffeine metabolism in the newborn. Clin Pharmacol Ther 25:447-453
11. Parsons WD, Neims AH 1981 Prolonged half-life of caffeine in healthy term newborn infants. J Pediatr 98:640-641
12. Daly JW 1993 Mechanism of action of caffeine. In: Garattini S (eds) Caffeine, Coffee and Health. Raven Press, New York, pp 97-150
13. Eskenazi B 1993 Caffeine during pregnancy: Grounds for concern. JAMA 270:2973¬2974
14. Fredholm BB, Dunwiddie TV 1988 How does adenosine inhibit transmitter release? Trends Pharmacol Sci 9:130-134
15. Evans MC, Swan JH, Meldrum BS 1987 An adenosine analogue, 2-chloroadenosine, protects against long term development of ischemic cell loss in the rat. Neurosci Lett 83:287-292
16. 1 region of gerbil hippocampus. Stroke 19:1133-1139
17. Dragunow M, Faull R 1988 Neuroprotective effects of adenosine. Trends Pharmacol Sci 9:193-194
18. Marangos PJ, vonLubitz DKJE, Daval JL, Deckert J 1990 Adenosine: Its relevance to the treatment of brain ischemia and trauma. Prog Clin Res 361:331-349
19. Miller LP, Hsu C 1992 Therapeutic potential of adenosine receptor activation in ischemic brain injury. J Neurotrauma 9:563-577
20. Rudolphi KA, Schubert P, Parkinson FE, Fredholm BB 1992 Neuroprotective role of adenosine in cerebral ischemia. Trends Pharmacol Sci 13:439-445
21. Berne RN, Rubio R, Curnish RR 1974 Release of adenosine from ischemic brain. Circ Res 35:262-271
22. Hagberg H, Andersson P, Lacarewicz J, Jacobson I, Butcher S, Sandberg M 1987 Extracellular adenosine, inosine, hypoxanthine, and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia. J Neurochem 49:227-231
23. Lee KS, Tetzlaff W, Kreutzberg GW 1986 Rapid downregulation of hippocampal adenosine receptors following brief anoxia. Brain Res 380:155-158
24. Aden U, Lindström K, Bona E, Hagberg H, Fredholm BB 1994 Changes in adenosine receptors in the neonatal rat brain following hypoxic ischemia. Mol Brain Res 23:354-358
25. Rudolph KA, Keil M, Fastbom J, Fredholm BB 1989 Ischaemic damage in gerbi hippocampus is reduced following uprcgulation of adenosine (Al) receptors by caffeine rcatment. Neurosci Lett 103:275-280
26. Rudolphi KA, Keil M, Grome JJ 1990 Adenosine-a pharmacological concept for the treatment of cerebral ischemia? In: Krieglstein J, Oberpichler H (eds) Pharmacology of Cerebral Ischemia. Wissenschaftliche Vcrlagsgesellschaft mbH, Stuttgart, pp 439-448
27. Guillet R 1990 Neonatal caffeine exposure alters adenosine receptor control of locomotor activity. Dev Pharmacol Ther 15:94-100
28. 1 area of rat hippocampus. Dev Brain Res 55:147-150
29. Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M 1994 Nomenclature and classification of purinoceptors. Pharma¬col Rev 46:143-156
30. Guillet R, Kellogg C 1991 Neonatal exposure to therapeutic caffeine alters the ontogeny of adenosine Al receptors in brain of rats. Neuropharmacology 30:489-496
31. Andine P, Thordstcin M, Kjellmer I, Nordborg C, Thiringer K, Wennberg E, Hagberg H 1990 Evaluation of brain damage in a rat model of neonatal hypoxic-ischemia. J Neurosci Methods 35:253-260
32. Gilland E, Puka-Sundvall M, Andine P, Bona E, Hagberg H 1994 Hypoxic-ischemic in the neonatal rat brain: Effects of pre- and post-treatment with the glutamate release inhibitor BW1003C87. Dev Brain Res 83:79-84
33. Hagberg H, Gilland E, Dicmer NH, Andine P 1994 Hypoxia-ischemia in the neonatal rat brain: Histopathology after post-treatment with NMDA and non-NMDA receptor antagonists. Biol Neonate 66:206-213
34. McDonald JW, Roeser NF, Silverstcin FS, Johnston MV 1989 Quantitative assess¬ment of neuroprotection against NMDA-İnduced brain injury. Exp Neurol 106:289¬296
35. Towfighi J, Housman C, Vannucci RC, Heitjan DF 1994 Effect of unilateral perinatal hypoxic-ischemic brain damage on the gross development of opposite cerebral hemisphere. Biol Neonate 65:108-118
36. Parkinson FE, Fredholm BB 1992 Magnesium-dependent enhancement of endoge¬nous agonist binding to adenosine Al receptors: A complicating factor in quantitative autoradiography. J Neurochcm 58:941-950
37. Johansson B, Ahlberg S, van der Ploeg I, Brene S, Lindefors N, Persson H, Fredholm BB 1993 Effect of long term caffeine treatment on Al and A2 adenosine receptor binding and on mRNA levels. Naunun Schmiedebergs Arch Pharmacol 347:407-414
38. Dux E, Fastbom J, Ungerstedt U, Rudolphi KA, Fredholm BB 1990 Protective effect of adenosine and a novel xanthine derivative propentofylline on the cell damage after bilateral carotid occlusion in the gerbil hippocampus. Brain Res 516:248-256
39. DeLeo J, Toth L, Schubert P, Rudolphi K, Kreutzberg GW 1987 Ischemia-induced neuronal cell death, calcium accumulation and glial response in the hippocampus of the Mongolian gerbil and protection by propentofylline (HWA 285). J Cercb Blood Flow Mctab 7:745-752
40. Hagberg H, Andine P, Fredholm BB, Rudolphi KA 1990 Effect of the adenosine uptake inhibitor propentofylline on extracellular adenosine and glutamate and eval¬uation of its neuroprotective efficacy after ischemia in neonatal and adult rats. In: Krieglstein J, Oberpichler H (eds) Pharmacology of Cerebral Ischemia. Wissen¬schaftliche Verlagsgesellschaft mbH, Stuttgart, pp 427-437
41. DeLeo J, Schubert P, Kreutzberg GW 1988 Propentofylline (HWA 285) protects hippocampal neurons of Mongolian gerbils against ischemic damage in the presence of an adenosine antagonist. Neurosci Lett 84:307-311
42. Chiswick ML 1985 Intrauterine growth retardation. Br Med J 291:845-848
43. Yager JY, Heitjan DF, Towfighi J, Vannucci RC 1992 Effect of insulin-induced and fasting hypoglycemia on perinatal hypoxic-ischemic brain damage. Pcdialr Res 31:138-142
44. Georgicv V, Johansson B, Fredholm BB 1993 Long-term caffeine treatment leads to a decreased susceptibility to NMDA-induccd clonic seizures İn mice without changes in adenosine Al receptor number. Brain Res 612:271-277
45. Rudolphi KA, Schubert P, Parkinson FE, Fredholm BB 1992 Adenosine and brain ischemia. Cerebrovasc Brain Metab Rev 4:346-369
46. Shi D, Nikodijevic O, Jacobson KA, Daly JW 1993 Chronic caffeine alters the density of adenosine, adrenergic, cholinergic, GABA, and serotonin receptors and calcium channels İn mouse brain. Cell Mol Ncurobiol 13:247-261
47. Slernau LL, Lust WD, Ricci AJ, Ratcheson R 1989 Role for y-aminobutyric acid in selective vulnerability in gerbils. Stroke 20:281-287
48. Johansson B, Lindström K, Fredholm BB 1994 Differences in the regional and cellular localization of c-fo.s mRNA induced by amphetamine, cocaine and caffeine in the rat. Ncuroscicnce 59:837-849
49. Romijn HJ, Hofman MA, Gramsbergen A 1991 At what age is the developing cerebral cortex of the rat comparable to that of the full-term newborn human baby? Early Hum Dev 26:61-67