-
1
-
-
0020368217
-
Inhibition of adrenocorticotropic hormone secretion in the rat by immunoneutralization of corticotropin-releasing factor
-
Rivier, C., J. Rivier, and W. Vale. 1982. Inhibition of adrenocorticotropic hormone secretion in the rat by immunoneutralization of corticotropin-releasing factor. Science (Wash. DC). 218:377-379.
-
(1982)
Science (Wash. DC)
, vol.218
, pp. 377-379
-
-
Rivier, C.1
Rivier, J.2
Vale, W.3
-
2
-
-
0022559210
-
Mediation by corticotropin-releasing factor (CRF) or adenohypophyseal hormone secretion
-
Rivier, C. L., and P. M. Plotsky. 1986. Mediation by corticotropin-releasing factor (CRF) or adenohypophyseal hormone secretion. Annu. Rev. Physiol. 48:475-494.
-
(1986)
Annu. Rev. Physiol.
, vol.48
, pp. 475-494
-
-
Rivier, C.L.1
Plotsky, P.M.2
-
3
-
-
0020689401
-
Chemical and biological characterization of corticotropin-releasing factor
-
Vale, W., C. Rivier, M. R. Brown, J. Spiess, G. Koob, L. Swanson, L. Bilezikjian, F. Bloom, and J. Rivier. 1983. Chemical and biological characterization of corticotropin-releasing factor. Recent Prog. Horm. Res. 39:245-270.
-
(1983)
Recent Prog. Horm. Res.
, vol.39
, pp. 245-270
-
-
Vale, W.1
Rivier, C.2
Brown, M.R.3
Spiess, J.4
Koob, G.5
Swanson, L.6
Bilezikjian, L.7
Bloom, F.8
Rivier, J.9
-
4
-
-
0021968129
-
Effects of adrenalectomy and dexamethasone administration on the level of prepro-corticotropin-releasing factor messenger ribonucleic acid (mRNA) in the hypothalamus and adrenocorticotropin/β-lipotropin precursor mRNA in the pituitary in rats
-
Jingami, H., S. Matukura, S. Numa, and H. Imura. 1985. Effects of adrenalectomy and dexamethasone administration on the level of prepro-corticotropin-releasing factor messenger ribonucleic acid (mRNA) in the hypothalamus and adrenocorticotropin/β-lipotropin precursor mRNA in the pituitary in rats. Endocrinology. 117:1314-1320.
-
(1985)
Endocrinology
, vol.117
, pp. 1314-1320
-
-
Jingami, H.1
Matukura, S.2
Numa, S.3
Imura, H.4
-
5
-
-
0022532790
-
Quantitative in situ hybridization histochemistry reveals increased levels of corticotropin-releasing factor mRNA after adrenalectomy
-
Young, W. S., E. Mezey, and R. E. Siegel. 1986. Quantitative in situ hybridization histochemistry reveals increased levels of corticotropin-releasing factor mRNA after adrenalectomy. Neurosci. Lett. 70:198-203.
-
(1986)
Neurosci. Lett.
, vol.70
, pp. 198-203
-
-
Young, W.S.1
Mezey, E.2
Siegel, R.E.3
-
6
-
-
0025937227
-
Differential regulation of corticotropin-releasing factor mRNA in rat brain regions by glucocorticoids and stress
-
Imaki, T., J.-L. Nahon, C. Rivier, P. E. Sawchenko, and W. Vale. 1991. Differential regulation of corticotropin-releasing factor mRNA in rat brain regions by glucocorticoids and stress. J. Neurosci. 11:585-599.
-
(1991)
J. Neurosci.
, vol.11
, pp. 585-599
-
-
Imaki, T.1
Nahon, J.-L.2
Rivier, C.3
Sawchenko, P.E.4
Vale, W.5
-
7
-
-
0023680578
-
Corticotropin-releasing factor, vasopressin and pro-opiomelanocortin mRNA responses to stress and opiates in the rat
-
Lightman, S. L., and W. S. Young III. 1988. Corticotropin-releasing factor, vasopressin and pro-opiomelanocortin mRNA responses to stress and opiates in the rat. J. Physiol. (Lond.) 403:511-523.
-
(1988)
J. Physiol. (Lond.)
, vol.403
, pp. 511-523
-
-
Lightman, S.L.1
Young III, W.S.2
-
8
-
-
0024399181
-
A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall-induced arthritis in Lewis rats
-
Sternberg, E. M., W. S. Young III., R. Bernardini, A. Calogero, G. P. Chrousos, P. W. Gold, and R. L. Wilder. 1989. A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall-induced arthritis in Lewis rats. Proc. Natl. Acad. Sci. USA. 86:4771-4775.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 4771-4775
-
-
Sternberg, E.M.1
Young III, W.S.2
Bernardini, R.3
Calogero, A.4
Chrousos, G.P.5
Gold, P.W.6
Wilder, R.L.7
-
9
-
-
0024468010
-
Responses of hypothalamic and pituitary mRNA to physical and psychological stress in the rat
-
Harbuz, M. S., and S. L. Lightman. 1989. Responses of hypothalamic and pituitary mRNA to physical and psychological stress in the rat. J. Endocrinol. 122:705-711.
-
(1989)
J. Endocrinol.
, vol.122
, pp. 705-711
-
-
Harbuz, M.S.1
Lightman, S.L.2
-
10
-
-
0023933341
-
Expression and dexamethasone regulation of the human corticotropin-releasing hormone gene in a mouse anterior pituitary cell line
-
Adler, K. A., C. M. Smas, and J. A. Majzoub. 1988. Expression and dexamethasone regulation of the human corticotropin-releasing hormone gene in a mouse anterior pituitary cell line. J. Biol. Chem. 263:5846-5852.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 5846-5852
-
-
Adler, K.A.1
Smas, C.M.2
Majzoub, J.A.3
-
11
-
-
0025118609
-
Glucocorticoid repression of 3′,5′-cyclic-adenosine monophosphate-dependent human corticotropin-releasing hormone gene promoter activity in a transfected mouse anterior pituitary cell line
-
Van, L. P., D. H. Spengler, and F. Holsboer. 1990. Glucocorticoid repression of 3′,5′-cyclic-adenosine monophosphate-dependent human corticotropin-releasing hormone gene promoter activity in a transfected mouse anterior pituitary cell line. Endocrinology. 127:1412-1418.
-
(1990)
Endocrinology
, vol.127
, pp. 1412-1418
-
-
Van, L.P.1
Spengler, D.H.2
Holsboer, F.3
-
12
-
-
0026505037
-
Effects of glucocorticoid on corticotropin-releasing hormone gene regulation by second messenger pathways in NPLC and AtT-20 cells
-
Rosen, L. B., J. A. Majzoub, and G. K. Adler. 1992. Effects of glucocorticoid on corticotropin-releasing hormone gene regulation by second messenger pathways in NPLC and AtT-20 cells. Endocrinology. 130:2237-2244.
-
(1992)
Endocrinology
, vol.130
, pp. 2237-2244
-
-
Rosen, L.B.1
Majzoub, J.A.2
Adler, G.K.3
-
13
-
-
85012580493
-
Quantitation of nuclear low-level gene expression in central nervous system using solution hybridization and in situ hybridization
-
P. M. Conn, editor. Academic Press, Inc., San Diego
-
Blum, M., and J. L. Roberts. 1989. Quantitation of nuclear low-level gene expression in central nervous system using solution hybridization and in situ hybridization. In Gene Probes. P. M. Conn, editor. Academic Press, Inc., San Diego. 293-303.
-
(1989)
Gene Probes
, pp. 293-303
-
-
Blum, M.1
Roberts, J.L.2
-
14
-
-
0023124162
-
Glucocorticoids enhance stability of human growth hormone mRNA
-
Paek, I., and R. Axel. 1987. Glucocorticoids enhance stability of human growth hormone mRNA. Mol. Cell. Biochem. 7:1496-1507.
-
(1987)
Mol. Cell. Biochem.
, vol.7
, pp. 1496-1507
-
-
Paek, I.1
Axel, R.2
-
15
-
-
0023892879
-
The vasopressin mRNA poly (A) tract is unusually long and increases during stimulation of vasopressin gene expression in vivo
-
Carrazana, E. J., K. B. Pasieka, and J. A. Majzoub. 1988. The vasopressin mRNA poly (A) tract is unusually long and increases during stimulation of vasopressin gene expression in vivo. Mol. Cell. Biol. 8:2267-2274.
-
(1988)
Mol. Cell. Biol.
, vol.8
, pp. 2267-2274
-
-
Carrazana, E.J.1
Pasieka, K.B.2
Majzoub, J.A.3
-
16
-
-
0023782218
-
Regulation of poly(A) tail size of vasopressin mRNA
-
Zingg, H. H., D. L. Lafebvre, and G. Almazan. 1988. Regulation of poly(A) tail size of vasopressin mRNA. J. Biol. Chem. 263:11041-11043.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 11041-11043
-
-
Zingg, H.H.1
Lafebvre, D.L.2
Almazan, G.3
-
17
-
-
0026753964
-
Early induction of c-fos precedes increased expression of corticotropin-releasing factor mRNA in the paraventricular nucleus after immobilization stress
-
Imaki, T., T. Shibasaki, M. Hotta, and H. Demura. 1992. Early induction of c-fos precedes increased expression of corticotropin-releasing factor mRNA in the paraventricular nucleus after immobilization stress. Endocrinology. 131:240-246.
-
(1992)
Endocrinology
, vol.131
, pp. 240-246
-
-
Imaki, T.1
Shibasaki, T.2
Hotta, M.3
Demura, H.4
-
18
-
-
84909652794
-
Gene expression II
-
B. Lewin, editor. Wiley-Liss, Inc., New York
-
Lewin, B. 1980. Gene expression II. In Eukaryotic Chromosomes. B. Lewin, editor. Wiley-Liss, Inc., New York. 728-864.
-
(1980)
Eukaryotic Chromosomes
, pp. 728-864
-
-
Lewin, B.1
-
19
-
-
0020842655
-
The processing of RNA
-
Darnell, J. E., Jr. 1983. The processing of RNA. Sci. Am. 249:90-100.
-
(1983)
Sci. Am.
, vol.249
, pp. 90-100
-
-
Darnell Jr., J.E.1
-
20
-
-
0022852717
-
Regulation of pro-opiomelanocortin gene transcription in individual cell nuclei
-
Fremeau, R. T., J. R. Lundblad, Jr., D. B. Pritchett, J. N. Wilcox, and J. L. Roberts. 1986. Regulation of pro-opiomelanocortin gene transcription in individual cell nuclei. Science (Wash. DC). 234:1265-1269.
-
(1986)
Science (Wash. DC)
, vol.234
, pp. 1265-1269
-
-
Fremeau, R.T.1
Lundblad Jr., J.R.2
Pritchett, D.B.3
Wilcox, J.N.4
Roberts, J.L.5
-
21
-
-
0024446143
-
Changes in rat pituitary nuclear and cytoplasmic pro-opiomelanocortin RNAs associated with adrenalectomy and glucocorticoid replacement
-
Autelitano, D. L., M. Blum, and J. L. Roberts. 1989. Changes in rat pituitary nuclear and cytoplasmic pro-opiomelanocortin RNAs associated with adrenalectomy and glucocorticoid replacement. Mol. Cell. Endocrinol. 66:171-180.
-
(1989)
Mol. Cell. Endocrinol.
, vol.66
, pp. 171-180
-
-
Autelitano, D.L.1
Blum, M.2
Roberts, J.L.3
-
22
-
-
0025993497
-
In situ hybridization analysis of arginine vasopressin gene transcription using intron-specific probes
-
Herman, J. P., M. K.-H. Schafer, S. J. Watson, and T. G. Sherman. 1991. In situ hybridization analysis of arginine vasopressin gene transcription using intron-specific probes. Mol. Endocrinol. 5:1447-1456.
-
(1991)
Mol. Endocrinol.
, vol.5
, pp. 1447-1456
-
-
Herman, J.P.1
Schafer, M.K.-H.2
Watson, S.J.3
Sherman, T.G.4
-
23
-
-
0027196720
-
In situ hybridization of arginine vasopressin (AVP) heteronuclear ribonucleic acid reveals increased AVP gene transcription in the rat hypothalamic paraventricular nucleus in response to emotional stress
-
Priou, A., C. Oliver, and M. Grino. 1993. In situ hybridization of arginine vasopressin (AVP) heteronuclear ribonucleic acid reveals increased AVP gene transcription in the rat hypothalamic paraventricular nucleus in response to emotional stress. Acta Endocrinol. 128:466-472.
-
(1993)
Acta Endocrinol.
, vol.128
, pp. 466-472
-
-
Priou, A.1
Oliver, C.2
Grino, M.3
-
24
-
-
0026643469
-
Rapid regulation of corticotropin-releasing hormone gene transcription in vivo
-
Herman, J. P., M. K.-H. Schafer, R. C. Thompson, and S. J. Watson. 1992. Rapid regulation of corticotropin-releasing hormone gene transcription in vivo. Mol. Endocrinol. 6:1061-1069.
-
(1992)
Mol. Endocrinol.
, vol.6
, pp. 1061-1069
-
-
Herman, J.P.1
Schafer, M.K.-H.2
Thompson, R.C.3
Watson, S.J.4
-
25
-
-
0023619112
-
The rat corticotropin-releasing hormone gene: Sequence and tissue-specific expression
-
Thompson, R. C., A. F. Seasholtz, and E. Herbert. 1987. The rat corticotropin-releasing hormone gene: sequence and tissue-specific expression. Mol. Endocrinol. 1:363-370.
-
(1987)
Mol. Endocrinol.
, vol.1
, pp. 363-370
-
-
Thompson, R.C.1
Seasholtz, A.F.2
Herbert, E.3
-
26
-
-
0025959674
-
Stimulus-transcription coupling in the nervous system: Involvement of the inducible proto-oncogenes fos and Jun
-
Morgan, J. L., and T. Curran. 1991. Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and Jun. Annu. Rev. Neurosci. 14:421-451.
-
(1991)
Annu. Rev. Neurosci.
, vol.14
, pp. 421-451
-
-
Morgan, J.L.1
Curran, T.2
-
27
-
-
0023891990
-
Expression of c-fos protein in brain: Metabolic mapping at the cellular level
-
Sager, S. M., F. R. Sharp, and T. Curran. 1988. Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science (Wash. DC). 240:1328-1331.
-
(1988)
Science (Wash. DC)
, vol.240
, pp. 1328-1331
-
-
Sager, S.M.1
Sharp, F.R.2
Curran, T.3
-
28
-
-
0024425142
-
The use of c-fos as a metabolic marker in neuronal pathway tracing
-
Dragunow, M., and R. Faull. 1989. The use of c-fos as a metabolic marker in neuronal pathway tracing. J. Neurosci. Methods. 29:261-265.
-
(1989)
J. Neurosci. Methods
, vol.29
, pp. 261-265
-
-
Dragunow, M.1
Faull, R.2
-
29
-
-
0024357992
-
Expression of c-fos immunoreactivity in transmitter-characterized neurons after stress
-
Ceccatelli, S., M. J. Vilar, M. Goldstein, and T. Hokfelt. 1989. Expression of c-fos immunoreactivity in transmitter-characterized neurons after stress. Proc. Natl. Acad. Sci. USA. 86:9569-9573.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 9569-9573
-
-
Ceccatelli, S.1
Vilar, M.J.2
Goldstein, M.3
Hokfelt, T.4
-
30
-
-
0026006171
-
c-fos mRNA, fos, and fos-related antigen induction by hypertonic saline and stress
-
Sharp, F. R., S. M. Sager, K. Hicks, D. Lowenstein, and K. Hisanaga. 1991. c-fos mRNA, fos, and fos-related antigen induction by hypertonic saline and stress. J. Neurosci. 11:2321-2331.
-
(1991)
J. Neurosci.
, vol.11
, pp. 2321-2331
-
-
Sharp, F.R.1
Sager, S.M.2
Hicks, K.3
Lowenstein, D.4
Hisanaga, K.5
-
31
-
-
0024384419
-
Widespread expression of corticotropin-releasing factor messenger RNA and immunoreactivity in the rat olfactory bulb
-
Imaki, T., J.-L. Nahon, P. E. Sawchenko, and W. Vale. 1989. Widespread expression of corticotropin-releasing factor messenger RNA and immunoreactivity in the rat olfactory bulb. Brain Res. 496:35-44.
-
(1989)
Brain Res.
, vol.496
, pp. 35-44
-
-
Imaki, T.1
Nahon, J.-L.2
Sawchenko, P.E.3
Vale, W.4
-
32
-
-
0026696090
-
Systemic administration of recombinant human growth hormone induces expression of c-fos gene in the hypothalamic arcuate and periventricular nuclei in hypophysectomized rats
-
Minami, S., K. Kamegai, H. Sugihara, O. Hasegawa, and I. Wakabayashi. 1992. Systemic administration of recombinant human growth hormone induces expression of c-fos gene in the hypothalamic arcuate and periventricular nuclei in hypophysectomized rats. Endocrinology. 131:247-253.
-
(1992)
Endocrinology
, vol.131
, pp. 247-253
-
-
Minami, S.1
Kamegai, K.2
Sugihara, H.3
Hasegawa, O.4
Wakabayashi, I.5
-
33
-
-
0024203305
-
Identification of a cyclic AMP-responsive element in the rat corticotropin-releasing hormone gene
-
Seasholtz, A. F., R. C. Thompson, and J. O. Douglass. 1988. Identification of a cyclic AMP-responsive element in the rat corticotropin-releasing hormone gene. Mol. Endocrinol. 2:1311-1319.
-
(1988)
Mol. Endocrinol.
, vol.2
, pp. 1311-1319
-
-
Seasholtz, A.F.1
Thompson, R.C.2
Douglass, J.O.3
-
34
-
-
0026332080
-
Physiology and pharmacology of corticotropin-releasing factor
-
Owens, M. J., and C. B. Nemeroff. 1991. Physiology and pharmacology of corticotropin-releasing factor. Pharmacol. Rev. 43:425-435.
-
(1991)
Pharmacol. Rev.
, vol.43
, pp. 425-435
-
-
Owens, M.J.1
Nemeroff, C.B.2
-
35
-
-
0023898447
-
Effects of adrenalectomy and glucocorticoids on the peptides CRF-41, AVP and oxytocin in rat hypophysial portal blood
-
Fink, G., I. C. A. F. Robinson, and L. A. Tannahill. 1988. Effects of adrenalectomy and glucocorticoids on the peptides CRF-41, AVP and oxytocin in rat hypophysial portal blood. J. Physiol. 401:329-334.
-
(1988)
J. Physiol.
, vol.401
, pp. 329-334
-
-
Fink, G.1
Robinson, I.C.A.F.2
Tannahill, L.A.3
-
36
-
-
0024332502
-
Glucocorticoid inhibition of stress-induced changes in hypothalami corticotrophin-releasing factor messenger RNA and proenkephalin A messenger RNA
-
Harbuz, M. S., and S. L. Lightman. 1989. Glucocorticoid inhibition of stress-induced changes in hypothalami corticotrophin-releasing factor messenger RNA and proenkephalin A messenger RNA. Neuropeptides. 14:17-20.
-
(1989)
Neuropeptides
, vol.14
, pp. 17-20
-
-
Harbuz, M.S.1
Lightman, S.L.2
-
37
-
-
0025642591
-
Stress responsiveness of hypothalamic corticotrophin-releasing factor and pituitary pro-opiomelanocortin mRNAs following high-dose glucocorticoid treatment and withdrawal in the rat
-
Harbuz, M. S., S. A. Nicholson, B. Gillham, and S. L. Lightman. 1990. Stress responsiveness of hypothalamic corticotrophin-releasing factor and pituitary pro-opiomelanocortin mRNAs following high-dose glucocorticoid treatment and withdrawal in the rat. J. Endocrinol. 127:407-415.
-
(1990)
J. Endocrinol.
, vol.127
, pp. 407-415
-
-
Harbuz, M.S.1
Nicholson, S.A.2
Gillham, B.3
Lightman, S.L.4
-
38
-
-
0027393449
-
Coexistence of c-fos and glucocorticoid receptor immunoreactivities in the CRF immunoreactive neurons of the paraventricular hypothalamic nucleus of the rat after acute immobilization stress
-
Covenas, R., M. de Leon, A. Cintra, B. Bjelke, J.-A. Gustafsson, and K. Fuxe. 1993. Coexistence of c-fos and glucocorticoid receptor immunoreactivities in the CRF immunoreactive neurons of the paraventricular hypothalamic nucleus of the rat after acute immobilization stress. Neurosci. Lett. 149:149-152.
-
(1993)
Neurosci. Lett.
, vol.149
, pp. 149-152
-
-
Covenas, R.1
De Leon, M.2
Cintra, A.3
Bjelke, B.4
Gustafsson, J.-A.5
Fuxe, K.6
-
39
-
-
0024405102
-
Influence of steroids on the hypothalamic corticotropin-releasing factor and preproenkephalin mRNA responses to stress
-
Lightman, S. L., and W. Scott Young III. 1989. Influence of steroids on the hypothalamic corticotropin-releasing factor and preproenkephalin mRNA responses to stress. Proc. Natl. Acad. Sci. USA. 86:4306-4310.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 4306-4310
-
-
Lightman, S.L.1
Scott Young III, W.2
-
40
-
-
8244264204
-
Adrenalectomy prevents a dynamic stimulatory challenge to parvocellular neurosecretory neurons
-
Bacon, E. R., and P. E. Sawchenko. 1993. Adrenalectomy prevents a dynamic stimulatory challenge to parvocellular neurosecretory neurons. Soc. Neurosci. Abstr. 19:760.
-
(1993)
Soc. Neurosci. Abstr.
, vol.19
, pp. 760
-
-
Bacon, E.R.1
Sawchenko, P.E.2
-
41
-
-
0025280697
-
Second messengers involved in the regulation of corticotropin-releasing hormone mRNA and peptide in cultured rat hypothalamic primary cultures
-
Emanuel, R. L., D. M. Girard, D. L. Thull, and J. A. Majzoub. 1990. Second messengers involved in the regulation of corticotropin-releasing hormone mRNA and peptide in cultured rat hypothalamic primary cultures. Endocrinology. 126:3016-3021.
-
(1990)
Endocrinology
, vol.126
, pp. 3016-3021
-
-
Emanuel, R.L.1
Girard, D.M.2
Thull, D.L.3
Majzoub, J.A.4
-
42
-
-
0026524768
-
Protein kinase-C activation increases the quantity and poly(A) tail length of corticotropin-releasing hormone messenger RNA in NPLC cells
-
Adler, G. K., L. B. Rosen, M. J. Fiandaca, and J. A. Majzoub. 1992. Protein kinase-C activation increases the quantity and poly(A) tail length of corticotropin-releasing hormone messenger RNA in NPLC cells. Mol. Endocrinol. 6:476-484.
-
(1992)
Mol. Endocrinol.
, vol.6
, pp. 476-484
-
-
Adler, G.K.1
Rosen, L.B.2
Fiandaca, M.J.3
Majzoub, J.A.4
-
43
-
-
0027161890
-
Regulated activity of the distal promoter-like element of human corticotropin releasing hormone gene and second structural features of its corresponding transcripts
-
Vamvakopoulos, N. C., and G. P. Chrousos. 1993. Regulated activity of the distal promoter-like element of human corticotropin releasing hormone gene and second structural features of its corresponding transcripts. Mol. Cell Endocrinol. 94:73-78.
-
(1993)
Mol. Cell Endocrinol.
, vol.94
, pp. 73-78
-
-
Vamvakopoulos, N.C.1
Chrousos, G.P.2
-
44
-
-
0027140870
-
Structural organization of the 5′ flanking region of the human corticotropin-releasing hormone gene
-
Vamvakopoulos, N. C., and G. P. Chrousos. 1993. Structural organization of the 5′ flanking region of the human corticotropin-releasing hormone gene. DNA Sequence-J DNA Sequencing and Mapping 4:197-206.
-
(1993)
DNA Sequence-J DNA Sequencing and Mapping
, vol.4
, pp. 197-206
-
-
Vamvakopoulos, N.C.1
Chrousos, G.P.2
|