RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase

FEBS Letters

Volumn 372, Issue 1, 1995, Pages 54-58

  Hamaguchi, Takuya ^a   Sudo, Tatsuhiko ^a   Osada, Hiroyuki ^a  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

CD45; cdc25B; Cell cycle; Microbial product; Tyrosine phosphatase inhibitor; VHR

Indexed keywords

3 HEXADECANOYL 5 HYDROXYMETHYLTETRONIC ACID; ENZYME INHIBITOR; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; RK 682; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL;

ANILINE COMPOUNDS; ANTIBIOTICS, ANTIFUNGAL; BLOTTING, WESTERN; CDC25 PHOSPHATASE; CELL CYCLE; CELL CYCLE PROTEINS; ENZYME INHIBITORS; ETHERS, CYCLIC; G1 PHASE; HUMAN; KINETICS; LEUKEMIA, B-CELL; OKADAIC ACID; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEINS; PHOSPHOTYROSINE; PROTEIN-TYROSINE-PHOSPHATASE; STREPTOMYCES; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED; VANADATES;

EID: 0029084113     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(95)00953-7     Document Type: Article

References (26)

1. Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor.
2. Morphological changes of human myeloid leukemia K562 cells by a protein phosphatase inhibitor, tautomycin.
3. Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide.