Flavonoids as antioxidant agents: Importance of their interaction with biomembranes

Free Radical Biology and Medicine

Volumn 19, Issue 4, 1995, Pages 481-486

  Saija, Antonella ^a   Scalese, Mario ^a   Lanza, Maria ^a   Marzullo, Daniela ^a   Bonina, Francesco ^b   Castelli, Francesco ^c  

^a UNIVERSITY OF MESSINA   (Italy)

^b Institute of Pharmaceutical and Toxicological Chemistry School of Pharmacy ^*  (Italy)

^c UNIVERSITY OF CATANIA   (Italy)

Author keywords

Antioxidant activity; Flavonoids; Free radicals; Lipoperoxidation; Model membranes

Indexed keywords

DIPALMITOYLPHOSPHATIDYLCHOLINE; FLAVONOID; FREE RADICAL; HESPERETIN; LIPOSOME; MEMBRANE RECEPTOR; NARINGENIN; QUERCETIN;

ANTIOXIDANT ACTIVITY; ARTICLE; ARTIFICIAL MEMBRANE; AUTOOXIDATION; DIFFERENTIAL SCANNING CALORIMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPID PEROXIDATION; PRIORITY JOURNAL;

ANIMAL; ANTIOXIDANTS; BRAIN; CALORIMETRY, DIFFERENTIAL SCANNING; CELL MEMBRANE; COMPARATIVE STUDY; FERROUS COMPOUNDS; FLAVONES; LIPID PEROXIDATION; LIPOSOMES; MALE; MALONDIALDEHYDE; OXIDATION-REDUCTION; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY; RUTIN; THERMODYNAMICS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0029083486     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-5849(94)00240-K     Document Type: Article

References (42)

1. Oxy-radicals and related species: Their formation, lifetimes, and reactions
2. Free radical mechanisms in tissue injury
3. Lipid peroxidation and human diseases
4. Protective and adverse biological actions of phenolic antioxidants
5. The antioxidants of higher plants
6. Autoxidation of micelles and model membranes
7. Protection of linoleic acid hydroperoxide-induced cytotoxicity by phenolic antioxidants
8. Ascorbate and phenolic antioxidant interactions in prevention of liposomal oxidation
9. Flavonoids are scavengers of superoxide anions
10. Flavonoids as superoxide scavengers and antioxidants
11. Hydroxyl radical scavenging activity of flavonoids
12. Superoxide scavenging properties of flavonoids in non-enzymic system
13. In vitro scavenger activity of some flavonoids and melanins against 02
14. Antioxidant activity of flavonoids and reactivity with peroxy radical
15. Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation
16. Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures
17. Antioxidant properties of the flavonoids silibyn and (+)-cyanidanol-3: Comparison with butylated hydroxyanisole and butylated hydroxytoluene
18. Ascorbic acid and copper in linoleate oxidation. I. Measurement of oxidation by ultraviolet spectrophotometry and the thiobarbituric acid test
19. Lipid peroxidation and human diseases
20. Dynamic molecular organization in vesicles and membranes
21. Lipid phase transition and drug interactions
22. Effects of local anesthetics on membrane properties. I. Changes in the fluidity of phospholipid bilayers
23. Effects of anesthetic tetradecenols on phosphatidylcholine phase transitions
24. Order and dynamics in bilayers
25. Phosphorous assay in column chromatography
26. Determination of hydrophobic parameters by reversed-phase liquid chromatography: Theory, experimental techniques, and application in studies on quantitative structure-activity relationships
27. The role of chromatography in drug design
28. Calorimetric studies of the interaction of 4-biphenylacetic acid and its β-cyclodextrin inclusion compound with lipid model membrane
29. Macromolecular prodrug interaction with mixed lipid membrane
30. A general model for the interaction of foreign molecules with lipid membranes: Drugs and anaesthetics
31. Lipid phase transitions and phase diagrams II. Mixtures involving lipids
32. Opioid structure-lipid thermotropic behaviour correlation study on a series of DPPC liposomes containing opioids
33. Phospholipid-polyphenol complexes: A new concept in skin care ingredients
34. Inhibitions of the autoxidation of linoleic acid by flavonoids in micelles
35. Autoxidation of biological molecules. 4. Maximizing the antioxidant activity of phenols
36. Flavonoids as antioxidants: Determination of radical-scavenging efficiencies
37. Effects of flavonoids on non-enzymatic lipid peroxidation: Structure-activity relationship
38. Flavonoid type antioxidants: Free radical induced oxidation of silybin at neutral pH
39. Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids
40. Effect of flavonoids on hydroxyl radical formation by Fenton-type reactions; influence of the iron chelator
41. Drug-membrane interactions: Silymarin, silibyn and microsomal membranes