Angiotensin-converting enzyme in the human heart: Effect of the deletion/insertion polymorphism

Circulation

Volumn 92, Issue 6, 1995, Pages 1387-1388

  Danser, A H Jan ^a   Schalekamp, Maarten A D H ^a   Bax, Willem A ^a   Van Den Brink, Antoinette Maassen ^a   Saxena, Pramod R ^a   Riegger, Günter A J ^b   Schunkert, Heribert ^b  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

angiotensin; genetics

Indexed keywords

ANGIOTENSIN; DIPEPTIDYL CARBOXYPEPTIDASE;

ADOLESCENT; ADULT; ARTICLE; CARDIOMYOPATHY; CHILD; CORONARY ARTERY DISEASE; ENZYME ACTIVITY; FEMALE; GENE DELETION; GENE INSERTION; GENETIC POLYMORPHISM; GENOTYPE; HEART INFARCTION; HEART LEFT VENTRICLE HYPERTROPHY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0029083297     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.92.6.1387     Document Type: Article

References (13)

1. Cambien F, Poirier O, Lecerf L, Evans A, Cambou J-P, Arveiler D, Luc G, Bard J-M, Bara L, Ricard S, Tiret L, Amouyel P, Alhenc-Gelas F, Soubrier F. Deletion polymorphism in the gene for angiotensin converting enzyme is a potent risk factor for myocardial infarction. Nature. 1992;359:641-644.
2. Raynolds MV, Bristow MR, Bush EW, Abraham WT, Lowes BD, Zisman LS, Taft CS, Perryman MB, Angiotensin-converting enzyme DD genotype in patients with ischaemic or idiopathic dilated cardiomyopathy. Lancet. 1993;342:1073-1075.
3. Marian AJ, Yu Q-T, Workman R, Greve G, Roberts R. Angiotensin-converting enzyme polymorphism in hypertrophie cardiomyopathy and sudden cardiac death. Lancet. 1993;342:1085-1086.
4. Schunkert H, Hense H-W, Holmer SR, Stender M, Perz S, Keil U, Lorell BH, Riegger GAJ. Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. N Engl J Med. 1994;330:1634-1638.
5. Nakai K, Itoh C, Miura Y, Hotta K, Musha T, Itoh T, Miyakawa T, Iwasaki R, Hiramori K. Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese. Circulation. 1994;90:2199-2202.
6. Bohn M, Berge KE, Bakken A, Erikssen J, Berg K. Insertion/ deletion (I/D) polymorphism at the locus for angiotensin I-converting enzyme and myocardial infarction. Clin Genet. 1993; 43:292-297.
7. Lindpaintner K, Pfeffer MA, Kreutz R, Stampfer MJ, Grodstein F, LaMotte F, Buring J, Hennekens CH. A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med. 1995;332:706-711.
8. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990;86:1343-1346.
9. Costerousse O, Allegrini J, Lopez M, Alhenc-Gelas F. Angiotensin I-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes. Biochem J. 1993;290:33-40.
10. Boomsma F, Schalekamp MADH. Evaluation of a test kit for the rapid and simple colometric measurement of angiotensin I-converting enzyme in serum. J Clin Chem Clin Biochem. 1983;21:845-849.
11. Schunkert H, Dzau VJ, Tang SS, Hirsch AT, Apstein CS, Lorell BH. Increased rat cardiac converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy: effect on coronary resistance, contractility and relaxation. J Clin Invest. 1990;86:1913-1920.
12. Danser AHJ, Koning MMG, Admiraal PJJ, Sassen LMA, Derkx FHM, Verdouw PD, Schalekamp MADH. Production of angiotensin I and II at tissue sites in intact pigs. Am J Physiol. 1992;263:H429-H437.
13. Danser AHJ, van Kats JP, Admiraal PJJ, Derkx FHM, Lamers JMJ, Verdouw PD, Saxcna PR. Schalekamp MADH. Cardiac renin and angiotensins: uptake from plasma versus in situ synthesis. Hypertension. 1994;24:37-48.