Synthesis and biochemical studies of spirocyclic amino acids. II. Activity of 2-azaspiro[5.5]undecane-7-carboxylates as GABA-uptake inhibitors

European Journal of Medicinal Chemistry

Volumn 30, Issue 9, 1995, Pages 707-713

  Fleischhacker, W ^a   Lauritz, S ^a   Urban, E ^a   Baumann, P ^b   Bittiger, H ^b  

^a UNIVERSITY OF VIENNA   (Austria)

^b CIBA GEIGY LTD   (Switzerland)

Author keywords

GABA uptake inhibitor; spirocyclic amino acid; structure activity relationship

Indexed keywords

2 AZASPIRO[5.5]UNDECANE 7 CARBOXYLIC ACID DERIVATIVE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; AMINO ACID DERIVATIVE; NIPECOTIC ACID; SPIRO COMPOUND; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; COW; DRUG SYNTHESIS; GABAERGIC SYSTEM; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0029082519     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/0223-5234(96)88288-2     Document Type: Article

References (19)

1. Comparative assay of anticonvulsant and toxic potencies of sixteen GABAmimetic drugs
2. Muscimol binding in rat brain: Association with synaptic GABA receptors