Recognition of clonogenic leukemic cells, remission bone marrow and HLA-identical donor bone marrow by CD8+ or CD4+ minor histocompatibility antigen-specific cytotoxic T lymphocytes

Journal of Clinical Investigation

Volumn 96, Issue 2, 1995, Pages 877-883

  Faber, Laura M ^a   Van Hoeven, John Der ^a   Goulmy, Els ^a   Hooftman Den Otter, Annelies L ^a   Van Luxemburg Heijs, Simone A P ^a   Willemze, Roel ^a   Falkenburg, J H Frederick ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Clonogenic (leukemic) hematopoietic progenitor cells; Differential recognition; Graft versus host disease; Graft versus leukemia reactivity; Leukemia

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MINOR HISTOCOMPATIBILITY ANTIGEN;

ACUTE GRANULOCYTIC LEUKEMIA; ALLOGENIC BONE MARROW TRANSPLANTATION; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CELL CLONE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL; HLA SYSTEM; HUMAN; HUMAN CELL; MINOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL;

ACUTE DISEASE; BONE MARROW; BONE MARROW TRANSPLANTATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HEMATOPOIETIC STEM CELLS; HISTOCOMPATIBILITY; HLA ANTIGENS; HUMAN; LEUKEMIA, MYELOID; LEUKEMIA, MYELOID, CHRONIC-PHASE; MALE; MINOR HISTOCOMPATIBILITY ANTIGENS; REMISSION INDUCTION; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES, CYTOTOXIC; TISSUE DONORS; TUMOR STEM CELL ASSAY; TUMOR STEM CELLS;

EID: 0029081517     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118134     Document Type: Article

References (49)

1. Butturini, A., and R. P. Gale. 1989. Clinical trials of T-cell depletion: current controversies, future directions. In Bone Marrow Transplant: Current Controversies. R. P. Gale and R. E. Champlin, editors. Alan R. Liss, Inc, New York. 495-509.
2. Horowitz, M. M., R. P. Gale, P. M. Sondel, J. M. Goldman, J. Kersey, H. J. Kolb, A. A. Rimm, O. Ringden, C. Rozman, B. Speck, R. L. Truitt, F. E. Zwaan, and M. M. Bortin. 1990. Graft-versus-leukemia reactions after bone marrow transplantation. Blood. 75:555-562.
3. Goldman, J. M., R. P. Gale, M. M. Horowitz, J. C. Biggs, R. E. Champlin, E. Gluckman, R. G. Hoffmann, S. J. Jacobsen, A. M. Marmont, P. B. McGlave, H. Messner, A. Rimm, C. Rozman, B. Speck, S. Tura, R. Weiner, and M. Bortin. 1988. Bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Increased risk for relapse associated with T-cell depletion. Ann. Intern. Med. 108:806-814.
4. Barrett, A. J., M. M. Horowitz, R. P. Gale, J. C. Biggs, B. M. Camitta, K. A. Dicke, R. A. Gluckman, R. A. Good, R. H. Herzig, M. B. Lee, A. M. Marmont, T. Masoaka, N. K. C. Ramsey, A. A. Rimm, B. Speck, F. E. Zwaan, and M. M. Bortin. 1989. Marrow transplantation for acute lymphoblastic leukemia: factors affecting relapse and survival. Blood. 74:862-871.
5. Marmont, A. M., M. M. Horowitz, R. P. Gale, K. Sobocinski, R. C. Ash, D. W. van Bekkum, R. E. Champlin, K. A. Dicke, J. M. Goldman, B. Speck, R. S. Weiner, and M. M. Bortin. 1991. T cell depletion of HLA-identical transplants in leukemia. Blood. 78:2120-2130.
6. Apperley, J. F., F. R. Mauro, J. M. Goldman, W. Gregory, C. K. Arthur, J. Hows, W. Arcese, G. Papa, F. Mandelli, D. Wardle, P. Gravett, G. Franklin, G. Bandini, P. Ricci, S. Tura, A. Iacone, G. Torlontano, W. Heit, R. Champlin, and R. P. Gale. 1988. Bone marrow transplantation for chronic myeloid leukaemia in first chronic phase: importance of a graft-versus-leukaemia effect. Br. J. Haematol. 69:239-245.
7. Weiden, P. L., N. Flournoy, E. D. Thomas, R. Prentice, A. Fefer, C. D. Buckner, and R. Storb. 1979. Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts. N. Engl. J. Med. 300:1068-1073.
8. Weiden, P. L., K. M. Sullivan, N. Flournoy, R. Storb, and E. D. Thomas. 1981. Antileukemic effect of chronic graft-versus-host disease: contribution to improved survival after allogeneic marrow transplantation. N. Engl. J. Med. 304:1529-1533.
9. Wagner, J. E., M. Zahurak, S. Piantadosi, R. B. Geller, G. B. Vogelsang, J. R. Wingard, R. Saral, C. Griffin, N. Shah. B. A. Zehnbauer, R. Armbinder, W. Burns, R. Jones, W. Stratford, S. Rowley, A. Yeager, and G. W. Santos. 1992. Bone marrow transplantation of chronic myelogenous leukemia in chronic phase: evaluation of risks and benefits. J. Clin. Oncol. 10:779-789.
10. Frassoni, F., M. Sessarego, A. Bacigalupo, P. Strada, M. Repetto, S. Occhini, R. Defferari, and A. Marmont. 1988. Competition between recipient and donor cells after bone marrow transplantation for chronic myeloid leukemia. Br. J. Haematol. 69:471-475.
11. Frassoni, F., D. Scarpati, A. Bacigalupa, V. Vitale, R. Corvo, S. Miceli, F. Gualandi, D. Occhini, M. Clavio, and M. T. Van Lint. 1989. The effect of total body irradiation dose and chronic graft-versus-host disease on leukemic relapse after allogeneic bone marrow transplantation. Br. J. Haematol. 73:211-216.
12. Truitt, R. L., A. V. LeFever, C. C. Y. Shih, J. M. Jeske, and T. M. Martin. 1990. Graft-vs-leukemia effect. In Graft-vs-Host-Disease: Immunology, Pathophysiology, and Treatment. H. J. Burakoff, H. J. Deeg, I. Ferrara, and K. Atkinson, editors. Dekker, New York. 177-204.
13. Kolb, H. J., J. Mittermueller, C. Clemm, C. Holler, G. Ledderose, G. Brehm, M. Heim, and W. Wilmanns. 1990. Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood. 76:2462.
14. Porter, D. L., M. S. Roth, C. McGarigle, R. N. James, J. L. M. Ferrara, and J. H. Antin. 1994. Induction of Graft-versus-Host disease as immunotherapy for relapse chronic myeloid leukemia. N. Engl. J. Med. 330:100-106.
15. Bär, B. M. A. M., A. Schattenberg, E. J. B. M. Mensink, A. Geurts Van Kessel, T. F. C. M. Smetsers, G. H. J. N. Knops, E. H. P. Linders, and T. De Witte. 1993. Donor leukocyte infusions for chronic myeloid leukemia after allogeneic bone marrow transplantation. J. Clin. Oncol. 11:513.
16. Goulmy, E. 1988. Minor histocompatibility antigens in man and their role in transplantation. Transplant. Rev. 2:29-53.
17. Perreault, C., F. Decary, S. Brochu, M. Gyger, R. Belanger, and D. Roy. 1990. Minor histocompatibility antigens. Blood. 76:1269-1280.
18. Sondel, P. M., J. A. Hank, T. Wendel, B. Flynn, and M. J. Bozdech. 1983. HLA identical leukemia cells and T cell growth factor activate cytotoxic T cell recognition of minor locus histocompatibility antigens in vitro. J. Clin. Invest. 71:1779-1783.
19. Goulmy, E., A. Termijtelen, B. A. Bradley, and J. J. van Rood. 1977. Y-antigen killing by T cells of women is restricted by HLA. Nature (Lond.). 266:544-545.
20. Goulmy, E., J. W. Gratama, E. Blokland, F. E. Zwaan, and J. J. van Rood. 1983. A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host disease. Nature (Lond.). 302:159-161.
21. van der Harst, D., E. Goulmy, J. H. F., Falkenburg, Y. M. C. Kooy-Winkelaar, S. A. P. Luxemburg-Heijs, H. M. Goselink, and A. Brand. 1994. Recognition of minor histocompatibility antigens on lymphocytic and myeloid leukemic cells by cytotoxic T-cell clones. Blood. 83:1060-1066.
22. Falkenburg, J. H., H. M. Goselink, D. van der Harst, S. A. van Luxemburg Heijs, Y. M. Kooy Winkelaar, L. M. Faber, J. de Kroon, A. Brand, W. E. Fibbe, R. Willemze, and E. Goulmy. 1991. Growth inhibition of clonogenic leukemic precursor cells by minor histocompatibility antigen-specific cytotoxic T lymphocytes. J. Exp. Med. 174:27-33.
23. Voogt, P. J., E. Goulmy, W. E. Fibbe, W. F. Veenhof, A. Brand, and J. H. Falkenburg. 1988. Minor histocompatibility antigen H-Y is expressed on human hematopoietic progenitor cells. J. Clin. Invest. 82:906-912.
24. Voogt, P. J., E. Goulmy, W. F. Veenhof, M. Hamilton, W. E. Fibbe, J. J. van Rood, and J. H. Falkenburg. 1988. Cellularly defined minor histocompatibility antigens are differentially expressed on human hematopoietic progenitor cells. J. Exp. Med. 168:2337-2347.
25. Marijt, W. A. F., W. F. J. Veenhof, E. Goulmy, R. Willemze, J. J. van Rood, and J. H. F. Falkenburg. 1993. Minor histocompatibility antigen HA-1,-2,-4 and HY specific cytotoxic T cell clones inhibit human hematopoietic progenitor cell growth by a mechanism that is dependent on direct cell-cell contact. Blood. 82:3778-3785.
26. de Bueger, M., A. Bakker, J. J. van Rood, F. van der Woude, and E. Goulmy. 1992. Tissue distribution of human minor Histocompatibility antigens. J. Immunol. 149:1788-1794.
27. van Els, C. A., J. D'Amaro, J. Pool, E. Blokland, A. Bakker, P. J. van Elsen, J. J. van Rood, and E. Goulmy. 1992. Immunogenetics of human minor histocompatibility antigens: their polymorphism and immunodominance. Immunogenetics. 35:161-165.
28. Voogt, P. J., W. E. Fibbe, W. A. Marijt, E. Goulmy, W. F. Veenhof, M. Hamilton, A. Brand, F. E. Zwaan, R. Willemze, J. J. van Rood, and J. H. F. Falkenburg. 1990. Rejection of bone-marrow graft by recipient-derived cytotoxic T lymphocytes against minor histocompatibility antigens. Lancet. 335:131-134.
29. Faber, L. M., S. A. P. Van Luxemburg-Heijs, R. Willemze, and J. H. F. Falkenburg. 1992. Generation of leukemia-reactive cytotoxic T lymphocyte clones from the HLA-identical bone marrow donor of a patient with leukemia. J. Exp. Med. 176:1283-1289.
30. Goulmy, E. 1982. HLA-A-B restriction of cytotoxic T cells. In HLA-Typing: Methodology and Clinical Aspects. S. Ferrone and B. G. Solheim, editors. CRC Press, Inc, New York. 105-122.
31. Voogt, P. J., W. E. Fibbe, W. F. J. Veenhof, A. Brand, E. Goulmy, J. J. van Rood, and J. H. F. Falkenburg. 1987. Cell-mediated lysis of human hematopoietic progenitor cells. Leukemia. 1:427-431.
32. Fefer, A., K. M. Sullivan, P. Weiden, C. D. Buckner, G. Schoch, R. Storb, and E. D. Thomas. 1987. Graft versus leukemia effect in man: the relapse rate of leukemia is lower after allogeneic than after syngeneic transplantation. Prog. Clin. Biol. Res. 244:401-408.
33. Jones, R. J., R. F. Ambinder, S. Piantadosi, and G. W. Santos. 1991. Evidence of a graft-versus-lymphoma effect associated with allogeneic bone marrow transplantation. Blood. 77:649-653.
34. Schreiber, K. L., and J. Forman. 1990. Effect of graft-versus-host disease on anti-tumor immunity. J. Immunol. 144:2018-2026.
35. Aizawa, S., and T. Sado. 1991. Graft-versus-leukemia effect in MHC-compatible and incompatible allogeneic bone marrow transplantation of radiation-induced, leukemia-bearing mice. Transplantation. 52:885-889.
36. Glass, B., L. Uharek, W. Gassmann, B. Focks, H. Bolouri, H. Loeffler, and W. Ruchholtz. 1992. Graft-versus-leukemia activity after bone marrow transplantation does not require graft-versus-host disease. Ann. Hematol. 64:255-259.
37. Kaminski, E., J. Hows, S. Man, P. Brookes, S. Mackinnon, T. Hughes, O. Avakian, J. M. Goldman, and J. R. Batchelor. 1989. Prediction of graft versus host disease by frequency analysis of cytytoxic T cells after unrelated donor bone marrow transplantation. Transplantation. 48:608-613.
38. Irschick, E. U., F. Hladik, D. Niederwieser, W. Nussbaumer, E. Hooler, E. Kaminski, and C. Huber. 1992. Studies on the mechanism of tolerance of graft-versus-host disease in allogeneic bone marrow recipients at the level of cytotoxic T-cell precursor frequencies. Blood. 79:1622-1628.
39. Champlin, R., W. Ho, J. Gajewski, S. Feig, M. Bumison, G. Holey, K. Greenberg, I. Lee, I. Schmid, and J. Giorgi. 1990. Selective depletion of CD8+ T lymphocytes for prevention of graft-versus-host disease after allogeneic bone marrow transplantation. Blood. 76:418-423.
40. Deacock, S., A. Schwarer, R. Batchelor, J. Goldman, and R. Lechler. 1992. A rapid limiting dilution assay for measuring frequencies of alloreactive, interleukin-2-producing T cells in humans. J. Immunol. Methods. 147:83-92.
41. Sosman, J. A., K. R. Oettel, S. D. Smith, J. A. Hank, P. Fisch, and P. M. Sondel. 1990. Specific recognition of human leukemic cells by allogeneic T cells: II. Evidence for HLA-D restricted determinants on leukemic cells that are crossreactive with determinants present on unrelated nonleukemic cells. Blood. 75:2005-2016.
42. Truitt, R. L. and A. A. Atasoylu. 1991. Contribution of CD4+ and CD8+ T cells to graft-versus-host disease and graft-versus-leukemia reactivity after transplantation of MHC-compatible bone marrow. Bone marrow transplant. 8:51-58.
43. Okunewick, J. P., D. L. Kociban, L. L. Machen, and M. J. Buffo. 1991. The role of CD4 and CD8 T cells in the graft-versus-leukemia response in Rauscher murine leukemia. Bone marrow transplant. 8:445-452.
44. Theobald, M., T. Nierle, D. Bunjes, R. Arnold, and H. Heimpel. 1992. Host-specific interleukin-2-secreting donor T-cell precursors as predictors of acute graft-versus-host disease in bone marrow transplantation between HLA-identical siblings. N. Engl. J. Med. 327:1613-1619.
45. Nierle, T., D. Bunjes, R. Arnold, H. Heimpel, and M. Theobald. 1993. Quantitative assessment of posttransplant host-specific Interleukin-2-secreting T-helper cell precursors in patients with and without acute graft-versus-host disease after allogeneic HLA-identical sibling bone marrow transplantation. Blood. 81:841-848.
46. Theobald, M., and D. Bunjes. 1993. Pretransplant detection of human minor histocompatibility antigen-specific naive and memory interleukin-2-secreting T cells within class I major histocompatibility complex (MHC)-restricted CD8+ and class II MHC-restricted CD4+ T-cell subsets. Blood. 82:298-306.
47. Busque, L., and D. G. Gilliland. 1993. Clonal evolution in acute myeloid leukemia. Blood. 82:337-342.
48. Fialkow, P. J., J. W. Singer, W. H. Raskind, J. W. Adamson, R. J. Jacobson, I. D. Bernstein, L. W. Dow, V. Najfeld, and R. Veith. 1987. Clonal development, stem-cell differentiation, and clinical remissions in acute nonlymphocytic leukemia. N. Engl. J. Med. 317:468-473.
49. Fearon, E. R., P. J. Burke, C. A. Schiffer, B. A. Zehnbauer, and B. Vogelstein. 1986. Differentiation of leukemia cells to polymorphonuclear leukocytes in patients with acute nonlymphocytic leukemia. N. Engl. J. Med. 315:15-24.