The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

Cell

Volumn 81, Issue 5, 1995, Pages 727-736

  Franke, Thomas F ^a   Yang, Sung Il ^b   Chan, Tung O ^a   Datta, Ketaki ^a   Kazlauskas, Andrius ^c   Morrison, Deborah K ^b   Kaplan, David R ^b   Tsichlis, Philip N ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; WORTMANNIN;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; ENZYME ACTIVATION; FIBROBLAST; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMAL; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MICE; MODELS, BIOLOGICAL; ONCOGENE PROTEINS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PLATELET-DERIVED GROWTH FACTOR; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENES; RAS PROTEINS; RATS; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0029079275     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(95)90534-0     Document Type: Article

References (31)

1. The proteins encoded by v-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential
2. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
3. Structure, expressioon chromosomal mapping of c-akt: relationship to v-akt and its implications
4. AKT2, a putative oncogene encoding a member of a subfamily of protein serine/threonine protein kinases, is amplified in human ovarian carcinomas
5. 1 to bilayer membranes
6. Modular binding domains in signal transduction proteins
7. AH/PH domain mediated interaction between Akt molecules and its potential role in Akt regulation
8. Phospholipid signaling
9. Regulating S6 kinase
10. The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1
11. Dimerization of cell surface receptors in signal transduction
12. Expression and prognostic significance of platelet-derived growth factor and its receptors in epithelial ovarian neoplasms
13. Site-directed mutagenesis by overlap extension using the polymerase chain reaction
14. A general method for introducing a series of mutations into cloned DNA using the polymerase chain reaction
15. Phosphatidylinositol 3-kinase
16. Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins
17. GTPase-activating protein and phosophatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor β subunit
18. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracelullar signal-regulated kinase activation
19. Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase
20. Protein modules and signaling networks
21. Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase
22. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
23. Phosphatidylinositol-3-OH kinase as a direct target of Ras
24. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
25. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
26. Control of the Balb/c-3T3 cell cycle by nutrients and serum factors: analysis using platelet-derived growth factor and platelet-poor plasma
27. Binding of G protein βγ-subunits to pleckstrin homology domains
28. Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediator of the PDGF receptor's mitogenic signal
29. A survey of expressed genes in Caenorhabditis elegans
30. Evidence for two distinct phosphatidylinositol kinase in fibroblasts: implications for cellular regulation
31. The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C