Selective inhibition of cell proliferation and DNA synthesis by the polysulphated carbohydrate ι-carrageenan

Cancer Chemotherapy and Pharmacology

Volumn 36, Issue 4, 1995, Pages 325-334

  Hoffman, Richard ^a   Burns III, Walter Woodrow ^a   Paper, Dietrich H ^b  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Carrageenan; Growth factors

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CARBOHYDRATE; CARRAGEENAN; POLYSACCHARIDE SULFATE; RECEPTOR ANTIBODY; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR ALPHA;

ANGIOGENESIS; ANIMAL CELL; ANTICOAGULATION; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL LINE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CARCINOMA;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARRAGEENAN; CELL DIVISION; CELLS, CULTURED; DEPRESSION, CHEMICAL; DNA; DNA, NEOPLASM; ENDOTHELIUM; FEMALE; FIBROBLAST GROWTH FACTOR 2; GROWTH INHIBITORS; HUMAN; MALE; PROSTATIC NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0029077986     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/BF00689050     Document Type: Article

References (38)

1. Algal polysaccharides
2. Carrageenan: a review of its effects on the immune system
3. Analysis of the inhibition of tumour metastasis by sulphated polysaccharides
4. Evidence that sulphated polysaccharides inhibit tumour metastasis by blocking tumour-cell-derived heparanases
5. Toxicity of various carrageenans in the mouse
6. Carrageenans inhibit growth factor binding
7. Inhibition of binding of basic fibroblast growth factor to low and high affinity receptors by carrageenans
8. Inhibition of cell growth and tumorigenesis of human glioblastoma cells by a neutralizing antibody against human basic fibroblast growth factor
9. Response of low-passage human malignant gliomas in vitro to stimulation and selective inhibition of growth factor-mediated pathways
10. Basic fibroblast growth factor in human prostate cancer cells
11. A heparin-binding growth factor secreted from breast cancer cells homologous to a developmentally regulated cytokine
12. Overexpression of the c-erbB-2 protein in human breast tumor cell lines
13. Cytogenetic abnormalities and overexpression of receptors for growth factors in normal bronchial epithelium and tumour samples of lung cancer patients
14. Overexpression of acidic and basic growth factors in human pancreatic cancer correlates with advanced tumour stage
15. What is the evidence that tumors are angiogenesis-dependent?
16. Minireview: angiogenesis
17. Tumor growth dependent on Kaposi's sarcoma-derived fibroblast growth factor inhibited by pentosan polysulfate
18. Inhibition by pentosan polysulphate (PPS) of heparin-binding growth factors released from tumor cells and blockage by PPS of tumor growth in animals
19. Effects of heparin on vascular smooth muscle cells
20. Regulation of cellular proliferation by heparin and heparan sulphate
21. Administration of pentosan polysulphate to patients with human-immunodeficiency virus-associated Kaposi's sarcoma
22. Cell growth inhibition by interferons and tumour necrosis factor
23. A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity
24. Differential responsiveness of human breast cancer cell lines MCF-7 and T47D to growth factors and 17β-oestradiol
25. An antibody to the receptor for insulin-like growth factor I inhibits the growth of MCF-7 cells in tissue culture
26. The National Cancer Institute Cancer Drug Discovery and Development Program
27. Clonal growth of bovine vascular endothelial cells: fibroblast growth factor as a survival agent
28. Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM1470)
29. Phosphorothioate antisense oligonucleotides against basic fibroblast growth factor inhibit anchorage-dependent and anchorage-independent growth of a malignant glioblastoma cell line
30. Basic fibroblast growth factor in human melanoma
31. The affinity of fibroblast growth factors (FGFs) for heparin; FGF-heparan sulfate interactions in cells and extracellular matrix
32. Suppression of solid tumor growth by immunoneutralizing monoclonal antibody against human basic fibroblast growth factor
33. Suramin prevents neovascularisation and tumour growth through blocking of basic fibroblast growth factor activity
34. Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis
35. Inhibition of rat cervical epithelial cell growth by heparin and its reversal by EGF
36. Importance of size, sulfation, and anti-coagulant activity in the potentiation of acidic fibroblast growth factor by heparin
37. Identification of the basic fibroblast growth factor binding sequence in fibroblast heparan sulfate
38. Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor