In vitro drug release from HYC 141, a corticosteroid ester of high molecular weight hyaluronan

Journal of Controlled Release

Volumn 34, Issue 2, 1995, Pages 145-153

  Payan, E ^a   Jouzeau, J Y ^a   Lapicque, F ^a   Bordji, K ^a   Simon, G ^a   Gillet, P ^a   O'Regan, M ^b   Netter, P ^a  

^a CNRS   (France)

^b Fidia Advanced Biopolymers   (Italy)

Author keywords

Arthropathy; Biodegradable polymer; Hyaluronan; In vitro release; Methylprednisolone delivery

Indexed keywords

BUFFER; HYALURONIC ACID; HYALURONIC ACID DERIVATIVE; HYC 141; METHYLPREDNISOLONE; PHOSPHATE; POLYMER; PROTEIN; UNCLASSIFIED DRUG;

ARTHROPATHY; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG BLOOD LEVEL; DRUG HYDROLYSIS; DRUG RELEASE; DRUG SYNOVIAL FLUID LEVEL; HUMAN; HUMAN TISSUE; MOLECULAR WEIGHT; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TEMPERATURE; VISCOSITY;

EID: 0029076833     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(95)00002-P     Document Type: Article

References (38)

1. Determination of methylprednisolone and methylprednisolone acetate in synovial fluid using high-performance liquid chromatography
2. Viscosupplementation: A new concept in the treatment of osteoarthritis
3. Physico-chemical surface characterization of hyaluronic acid derivatives as a new class of biomaterials
4. Microspheres of hyaluronic acid esters
5. Sodium hyaluronate 0.25% used as a vehicle increases the bioavailability of topically administered gentamicin
6. Sodium hyaluronate as an ophtalmic vehicle: some factors governing its effect on the ocular absorption of pilocarpine
7. Deleterious effect of intraarticular hydrocortisone
8. Relationship between polymer viscosity and drug release from a matrix system
9. Viscoelastic and transient network properties of hyaluronic acid as a function of the concentration
10. Clinical trial of intraarticular injection of sodium hyaluronate in patients with osteoarthritis of the knee
11. Optical and physical properties of wet-spun films of Na-hyaluronate
12. Hyaluronan derivative microspheres as NGF delivery devices preparation methods and in vitro release characterization
13. Drug release from hydrocortisone esters of hyaluronic acid
14. Polymeric prodrugs: recent experience with devices formed from steroid esters of hyaluronic acid
15. Effects of the molecular weight of hyaluronic acid and its action mechanisms on experimental joint pain in rats
16. Intraarticular treatment with sodium hyaluronate in gonarthrosis
17. Therapeutic synergism between hyaluronic acid and dexamethasone in the intraarticular treatment of osteoarthritis of the knee: a preliminary open study
18. Steroid esters of hyaluronic acid in the treatment of rheumatoid arthritis
19. Diffusion and drug release in polymer films prepared from ester derivatives of hyaluronic acid
20. Pharmacologic and clinical aspects of intraarticular injection of hyaluronate
21. Drug release from membranes of hyaluronic acid and its esters
22. Methylprednisolone esters of hyaluronic acid in ophthalmic drug delivery: in vitro and in vivo release studies
23. Osteonecrosis of the femoral and humeral heads after intraarticular corticosteroid injections
24. Drug delivery systems using hyaluronan and its derivatives
25. Intraarticular treatment of knee osteoarthritis
26. Intraarticular injections of hyaluronic acid in the treatment of painful shoulder
27. Inflammatory reactions after intrasynovial injection of microcrystalline adrenocortico-steroid esters
28. Conformation of hyaluronate in neutral and alkaline solutions
29. Hydrolysis of methylprednisolone acetate by human serum cholinesterase
30. Separation and determination of lipophilic corticosteroids and benzothiazepin analogues by micellar electrokinetic chromatography using bile salts
31. Assay of synovial fluid hyaluronic acid using HPLC of hyaluronidase digests
32. Intraarticular injections with methylprednisolone acetate reduce osteoarthritic lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis
33. A new approach to the treatment of osteoarthritis: viscosupplementation
34. The influence of intraarticular hyaluronic acid on PGE2 and cAMP of synovial fluid
35. Enzymic and non-enzymic hydrolysis of a polymeric pro-drug: hydrocortisone esters of hyaluronic acid
36. Evaluation of high and low-molecular weight fractions of sodium hyaluronate and an ionic complex as adjuvants for topical ophthalmic vehicles containing pilocarpine
37. Antioxidant activity of synovial fluid, hyaluronic acid and two subcomponents of hyaluronic acid