Evidence that protein kinase C and mitogen activated protein kinase are not involved in the mechanism by which insulin stimulates translation in L6 myoblasts

Bioscience Reports

Volumn 15, Issue 1, 1995, Pages 37-46

  Thompson, Michael G ^a   Pascal, Monique ^b   Mackie, Steven C ^a   Thom, Amanda ^a   Morrison, Kenneth S ^a   Colette Backwell, F R ^a   Palmer, Robert M ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

cyclooxygenase; insulin; L6 myoblast; mitogen activated protein kinase; protein kinase C; translation

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; DACTINOMYCIN; IBUPROFEN; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; MYELIN BASIC PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOTRANSFERASE; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; RAPAMYCIN;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MYOBLAST; PROTEIN SYNTHESIS; TRANSLATION INITIATION;

AMINO ACID SEQUENCE; ANIMAL; ANTIBIOTICS, ANTIFUNGAL; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; CYCLOOXYGENASE INHIBITORS; DACTINOMYCIN; DOWN-REGULATION; ENZYME INHIBITORS; IBUPROFEN; INDOLES; INSULIN; MOLECULAR SEQUENCE DATA; MUSCLE FIBERS; POLYENES; PROTEIN KINASE C; PROTEINS; SIROLIMUS; SUPPORT, NON-U.S. GOV'T; TETRADECANOYLPHORBOL ACETATE; TRANSLATION, GENETIC;

EID: 0029074749     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1007/BF01200213     Document Type: Article

References (45)

1. The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf.
2. Increased phosphorylation of ribosomal protein S6 during meiotic maturation of Xenopus oocytes.
3. Mitogen-activated S6 kinase is stimulated via protein kinase C-dependent and independent pathways in Swiss 3T3 cells.
4. Stimulation of protein synthesis and phospholipase D activity by vasopressin and phorbol ester in L6 myoblasts
5. Involvement of Arachidonic Acid Metabolism in Insulin-stimulated Protein Synthesis in Cultured L6 Myocytes.