Protein dynamics in whole body and in splanchnic and leg tissues in type I diabetic patients

Journal of Clinical Investigation

Volumn 95, Issue 6, 1995, Pages 2926-2937

  Nair, K Sreekumaran ^a,b   Ford, G Charles ^a,b   Ekberg, Karin ^d   Fernqvist Forbes, Eva ^c   Wahren, John ^c  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d Endocrine Research Unit ^*

Author keywords

muscle; protein breakdown; protein synthesis; splanchnic; type I diabetes

Indexed keywords

AMINO ACID; INSULIN;

ADULT; AMINO ACID METABOLISM; ARTICLE; CLINICAL ARTICLE; DIABETES MELLITUS; HUMAN; KINETICS; LEG MUSCLE; MALE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; TISSUE METABOLISM; TRANSAMINATION;

EID: 0029073033     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118000     Document Type: Article

References (64)

1. Geyelin, H. R., G. Harrop, M. F. Murray, and E. Corwin. 1922. The use of insulin in juvenile diabetes. J. Metab. Res. 11:767-791.
2. Atchley, D. W., R. F. Loeb, D. W. Richards, E. I. M. Benedict, and M. E. Driscol. 1933. On diabetic acidosis: a detailed study of electrolyte balances following the withdrawal and reestablishment of insulin therapy. J. Clin. Invest. 12:297-326.
3. Walsh, C. H., N. G. Soler, H. James, T. C. Harvey, B. J. Thomas, J. H. Fremlin, M. G. Fitzgerald, and J. M. Malins. 1976. Studies in whole body potassium and whole body nitrogen in newly diagnosed diabetics. Quart. J. Med. 45:295-301.
4. Luck, J. M., G. Morrison, and L. F. Wilbur. 1928. The effect of insulin on the amino acid content of blood. J. Biol. Chem. 77:151-156.
5. Felig, P., J. Wahren, R. Sherwin, and G. Palaiologos. 1977. Amino acid and protein metabolism in diabetes. Arch. Intern. Med. 137:507-511.
6. Nair, K. S., D. Halliday, and J. S. Garrow. 1984. Increased energy expenditure in poorly controlled type I diabetic patients. Diabelologia. 27:13-16.
7. Nair, K. S., J. S. Garrow, C. Ford, R. F. Mahler, and D. Halliday. 1983. Effect of poor diabetic control and obesity on whole body protein metabolism in man. Diabetologia. 25:400-403.
8. Nair, K. S. 1984. Energy and protein metabolism in diabetes and obesity. PhD thesis. Council of National Academic Awards, London. 190 pp.
9. Robert, J. J., B. Beaufrere, J. Koziet, J. F. Desjeux, D. M. Bier, V. R. Young, and H. Lestradet. 1985. Whole body de novo amino acid synthesis in type I (insulin-dependent) diabetes studied with stable isotope-labeled leucine, alanine, and glycine. Diabetes. 34:67-73.
10. Nair, K. S., G. C. Ford, and D. Halliday. 1987. Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients. Metabolism. 36:491-495.
11. Umpleby, A. M., M. A. Boroujerdi, P. M. Brown, E. R. Carson, and D. H. Sonksen. 1988. The effect of metabolic control on leucine metabolism in type I (insulin-dependent) diabetic patients. Diabetologia. 28:131-141.
12. Tessari, P., R. Nosadini, R. Trevisan, S. V. De Krutzenberg, S. Inchiostro, E. Duner, G. Biolo, M. C. Marescotti, M. C. Tiengo, A. Tiengo, and G. Crepaldi. 1986. Defective suppression by insulin of leucine-carbon appearance and oxidation in type I, insulin-dependent diabetes mellitus. J. Clin. Invest. 177:1797-1804.
13. Tessari, P., G. Biolo, S. Inchiostro, L. Sacca, R. Nosadini, M. T. Boscarato, R. Trevisan, S. V. De Krutzenberg, and A. Tiengo. 1990. Effects of insulin on whole body and forearm leucine and KIC metabolism in type I diabetes. Am. J. Physiol. 259:E396-E103.
14. Luzi, L., P. Castellino, D. C. Simonson, A. S. Petrides, and R. A. DeFronzo. 1990. Leucine metabolism in IDDM: role of insulin and substrate availability. Diabetes. 39:38-48.
15. Pacy, P. J., K. S. Nair, C. Ford, and D. Halliday. 1989. Failure of insulin infusion to stimulate fractional muscle protein synthesis in type I diabetic patients. Diabetes. 38:618-624.
16. 5)phenylalanine methodologies. Clin. Sci. (Oxf.). 80:245-252.
17. 13C)leucine. Diabetologia. 33:433-443.
18. Nair, K. S., and K. C. Copeland. 1992. Protein metabolism in type I diabetic patients. In Protein Metabolism or Diabetic Mellitus. K. S. Nair, editor. Smith-Gordan, London. 233-245.
19. Fukagawa, N. K., K. L. Minaker, J. W. Rowe, M. N. Goodman, D. E. Matthews, D. M. Bier V. R., and V. R. Young. 1985. Insulin mediated reduction of whole body protein breakdown: dose response effects of leucine metabolism in post absorptive man. J. Clin. Invest. 76:306-311.
20. Louard, R. M., D. A. Figburg, R. A. Gelfand, and E. J. Barrett. 1992. Insulin sensitivity of protein and glucose metabolism in human forearm skeletal muscle. J. Clin. Invest. 90:2348-2354.
21. Gelfand, R. A., and E. J. Barrett. 1988. Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man. J. Clin. Invest. 80:1-6.
22. Dennie, S. C., Y. Liechty, Y. M. Liu, G. Brechtel, and A. D. Baron. 1991. Proteolysis in skeletal muscle and whole body in response to euglycemic hyperinsulinemia in normal adults. Am. J. Physiol. 261:E809-E814.
23. Heslin, M. J., E. Newman, R. F. Wolfe, P. W. T. Pister, and M. F. Brennan. 1992. Effect of hyperinsulinemia in whole body and skeletal muscle leucine kinetics in humans. Am. J. Physiol. 262:E911-E918.
24. Arfvidsson, B., H. Zachrisson, A.-C. Moller-Loswick, A. Hyltauder, R. Sandstrom, and K. Lundholm. 1991. Effect of systemic hyperinsulinemia on amino acid flux across human legs in postabsorptive state. Am. J. Physiol. 260:E46-E52.
25. Wahren, J., P. Felig, and L. Hagenfeldt. 1976. Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus. J. Clin. Invest. 57:987-999.
26. Jefferson, L. S. 1980. Role of insulin in the regulation of protein synthesis. Diabetes. 29:487-496.
27. Proud, C. G. 1994. Turned on by insulin. Nature (Lond.). 371:747-748.
28. Pain, V. M., and P. J. Garlick 1974. Effect of streptozotocin diabetes and insulin treatment on the rate of protein synthesis in tissues of the rat in vivo. J. Biol. Chem. 249:4510-4514.
29. Pain, V. M., E. C. Albertse, and P. J. Garlick. 1983. Protein metabolism in skeletal muscle, diaphragm and heart of diabetic rats. Am. J. Physiol. 245:E604-E610.
30. Hagenfeldt, L. S., S. Ericksson, and J. Wahren. 1980. Influence of leucine on arterial concentrations and regional exchange of amino acids in healthy subjects. Clin. Sci. (Oxf.). 59:173-181.
31. Zierler, K. L., and D. Rabinowitz. 1963. Role of insulin and growth hormone based on studies of forearm. Medicine. 42:385-402.
32. Matthews, D. E., D. M. Bier, M. J. Rennie, R. H. T. Edwards, D. Halliday, D. J. Millward, and G. A. Plugston. 1981. Regulation of leucine metabolism in man: a stable isotope study. Science (Wash. DC). 214:1129-1131.
33. Schwenk, W. F., P. J. Berg, B. Beaufrere, J. M. Miles, and M. W. Haymond. 1984. Use of t-butyl-dimethylsilylation in the gas chromatographic/mass spectrometric analysis of physiologic compounds found in plasma using electron impact ionization. Anal. Biochem. 141:101-109.
34. 5]phenylalanine model. Am. J. Physiol. 256:E631-E639.
35. 13C)KIC in plasma by capillary gas chromatography/mass spectrometry in protein turnover studies. Biomed. Mass. Spec. 12:432-436.
36. 15N) leucine and forearm model. Eur. J. Clin. Invest. 15:345-353.
37. Jones, B., and J. Gilligan. 1983. Amino acid analysis by O-pthaldehyde precolumn derivitization and reversed phase HPLC. Am. Biotechnol. Lab. 12:45-51.
38. Hohorst, H. J. 1962. Methoden der enzymatishchen Analyse. H. U. Bergmeyer, editor. Verlag Chemie, Weinheim. 266-270.
39. Miles, J., R. A. J. Aikens, J. Gerich, and M. Haymond. 1993. A microfluorometric method for the determination of free fatty acids in plasma. J. Lipid Res. 24:96-99.
40. Williamson, D. H., and J. Mellanby. 1974. Methods of Enzymatic Analysis. Vol. 4. H. U. Bergmeyer, editor. Academic Press, Inc., New London. 1836-1843.
41. Arnqvist, H., P. O. Olsson, and H. von Shenck. 1987. Free and total insulin determined after precipitation with polyethylene glycol: analytical characteristics and effects of sample handling and storage. Clin. Chem. 33:93-96.
42. Harris, W., G. R. Faloona, and R. H. Unger. 1979. Glucagon. In Methods of Hormone Radioimmunoassay. B. M. Jaffee and H. R. Behrman, editors. Academic Press, Inc., New York. 643-655.
43. Baumann, G. 1990. Growth hormone binding proteins and various forms of growth hormone: implications for measurements. Acta Pediatr. Scand. 370(Suppl.):72-80.
44. Bang, P., U. Eriksson, V. Sara, I. L. Wivall, and K. Hall. 1991. Comparison of acid ethanol extraction and acid gel nitration prior to IGF-I and IGF-II radioimmunoassays: improvement of determination in acid ethanol extracts by use of truncated IGF-I as radioligand. Acta Endocrinol. (Copenh.). 124:620-629.
45. Povoa, G., A. Roovete, and K. Hall. 1984. Crossreaction of serum somatomedin-binding protein in a radioimmunoassay developed for somatomedin-binding protein isolated from human amniotic fluid. Acta Endocrinol. (Copenh.). 107:563-570.
46. Hjemdahl, P., M. Daleskog, and T. Kahan. 1979. Determination of plasma catecholamines by high performance liquid chromatography with electrochemical detection: comparison with radioenzymatic method. Life Sci. 25:131-138.
47. Wolfe, R. R., R. D. Goodenough, M. H. Wolfe, G. T. Royle, and E. R. Nadel. 1982. Isotopic analysis of leucine and urea metabolism in exercising humans. J. Appl. Physiol. 52:458-466.
48. Jefferson, L. S., J. B. Li, and S. R. Rannels. 1977. Regulation by insulin of amino acid release and protein turnover in the perfused rat hemicorpus. J. Biol. Chem. 252:1476-1483.
49. 14C]leucine kinetics in splanchnic and leg tissues in humans. Diabetes. 37:1364-1372.
50. Baillie, A. G. S., and P. J. Garlick. 1991. Attenuated responses of muscle protein synthesis to fasting and insulin in adult female rats. Am. J. Physiol. 262:E1-E5.
51. Nair, K. S., R. G. Schwartz, and S. Welle. 1987. Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans. Am. J. Physiol. 263:E928-E931.
52. Baumann, P. Q., W. S. Stirewait, B. D. O'Rourke, D. Howard, and K. S. Nair. 1994. Precursor pool of protein synthesis: a stable isotope study in a swine model. Am. J. Physiol. 267:E203-E209.
53. Layman, D. K., and R. R. Wolfe. 1987. Sample site selection for tracer studies applying a unidirectional circulatory approach. Am. J. Physiol. 253:E173-E178.
54. Schneible, P. A., J. Airhart, and R. B. Low. 1981. Differential compartmentation of leucine for oxidation and for protein synthesis in cultured skeletal muscle. J. Biol. Chem. 256:4888-4894.
55. Watt, P. W., Y. Lindsay, C. M. Scrimgeour, P. A. F. Chien, J. N. A. Gibson, D. J. Taylor, and M. J. Rennie. 1991. Isolation of aminoacyl-tRNA and its labeling with stable-isotope tracers: use in studies of human tissue protein synthesis. Proc. Natl. Acad. Sci. USA. 88:5892-5896.
56. Jefferson, L. S., J. W. Robertson, and C. M. Schworer. 1973. Effects of insulin and diabetes on hepatic protein turnover. Diabetes. 22:321-327.
57. Mortimore, G. E., and C. E. Mondon. 1970. Inhibition by insulin of valine turnover in liver. J. Biol. Chem. 245:2375-2383.
58. DeFeo, P., M. G. Gaisamo, and M. W. Haymond. 1991. Differential effects of insulin deficiency on albumin and fibrinogen synthesis in humans. J. Clin. Invest. 88:833-840.
59. Pacy, P. J., M. Read, and D. Halliday. 1990. Influence of insulin on albumin and non-albumin protein fractional synthetic rates in post-absorptive type I diabetic patients. Eur. J. Clin. Nutr. 44:343-349.
60. 5]phenylalanine. Am. J. Physiol. 267:E102-E108.
61. Copeland, K. C., K. S. Nair, P. B. Kaplowitz, D. C. Robbins, and J. Calles-Escandon. 1993. Discordant metabolic actions of insulin in extreme lipodystrophy of childhood. J. Clin. Endocrinol. Metab. 77:1240-1245.
62. Flakoll, P. J., M. Kulayat, M. Frexes-Steed, H. Hourani, L. L. Brown, J. O. Hull, and N. N. Abumrad. 1989. Amino acids augment insulin's suppression of whole body proteolysis. Am. J. Physiol. 257:E847.
63. Block, K. P., B. W. Haywood, M. G. Buse, and A. E. Harper. 1985. Activation of rat liver branched-chain 2-oxo-acid dehydrogenase in vivo by glucagon and adrenaline. Biochem. J. 232:593-597.
64. McNurtan, M. A., and P. J. Garlick. 1981. Protein synthesis in liver and small intestine in protein deprivation and diabetes. Am. J. Physiol. 241:E238-E245.