Molecular characterisation of two cell lines selected for resistance to the folate-based thymidylate synthase inhibitor, ZD1694

British Journal of Cancer

Volumn 71, Issue 5, 1995, Pages 925-930

  Freemantlel, S J ^a,c   Jackman, A L ^b   Kelland, L R ^b   Calvert, A H ^a   Lunec, J ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Drug resistance; Folate based TS inhibitors; Gene amplification; Thymidylate synthase (TS); ZD1694

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; ENZYME INHIBITOR; FOLIC ACID DERIVATIVE; MESSENGER RNA; QUINAZOLINE DERIVATIVE; RALTITREXED; THYMIDYLATE SYNTHASE;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG RESISTANCE; ENZYME INDUCTION; GENE AMPLIFICATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LYMPHOBLASTOID CELL LINE; OVARY CARCINOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BLOTTING, SOUTHERN; BLOTTING, WESTERN; COMPARATIVE STUDY; DNA; DNA, NEOPLASM; DRUG RESISTANCE; FEMALE; FOLIC ACID; HUMAN; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; POLYMERASE CHAIN REACTION; PROTEINS; QUINAZOLINES; RNA; RNA, NEOPLASM; SUPPORT, NON-U.S. GOV'T; THIOPHENES; THYMIDYLATE SYNTHASE; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0029072401     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.1995.179     Document Type: Article

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