Novel 2, 4-Diamino-5-Substituted-pyrrolo[2, 3-d]pyrimidines as Classical and Nonclassical Antifolate Inhibitors of Dihydrofolate Reductases

Journal of Medicinal Chemistry

Volumn 38, Issue 12, 1995, Pages 2158-2165

  Gangjee, Aleem ^a   Mavandadi, Farahnaz ^a   Queener, Sherry F ^b   McGuire, John J ^c  

^a DUQUESNE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 5 (ANILINOMETHYL)PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; 2,4 DIAMINO 5 CYANOPYRROLO[2,3 D]PYRIMIDINE; AMINOPTERIN; ANTINEOPLASTIC AGENT; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; N [4 [N [(2,4 DIAMINOPYRROLO[2,3 D]PYRIMIDIN 5 YL)METHYL]AMINO]BENZOYL]GLUTAMIC ACID; PYRIMETHAMINE; TRIMETHOPRIM; TRIMETREXATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG EFFICACY; DRUG MECHANISM; DRUG RESISTANCE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OPPORTUNISTIC INFECTION; PNEUMOCYSTIS CARINII; RAT; TOXOPLASMA GONDII;

FOLIC ACID ANTAGONISTS; HUMAN; PEPTIDE SYNTHASES; PYRIMIDINES; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0029072232     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00012a016     Document Type: Article

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