Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

Immunity

Volumn 2, Issue 6, 1995, Pages 665-675

  Szabo, Susanne J ^a   Jacobson, Nile G ^a   Dighe, Anand S ^a   Gubler, Uell ^b   Murphy, Kenneth M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 4;

ANIMAL CELL; ARTICLE; HELPER CELL; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

ANIMAL; BASE SEQUENCE; FEMALE; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PROTEIN-TYROSINE KINASE; PROTEINS; RECEPTORS, INTERLEUKIN; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TH1 CELLS; TH2 CELLS; TRANS-ACTIVATORS;

EID: 0029071483     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/1074-7613(95)90011-X     Document Type: Article

References (46)

1. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major
2. Interleukin-12 induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus tyrosine kinases by interleukin-2 and interleukin-12
3. 125I-containing acylating agent
4. + T lymphocytes
5. Requirement of endoge-nous interferon-gamma production for resolution of Listeria monocytogenes infection
6. IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts
7. Expression cloning of a human IL-12 receptor component: a new member of the cytokine receptor superfamily with strong homology to gp130
8. IL-12 receptor. II. Distribution and regulation of receptor expression
9. Interleukin-4 (IL-4) receptor expression on human T cells is affected by different intracellular signaling pathways and by IL-4 at transcriptional and posttranscriptional level
10. Identification of interleukin 4 receptor-associated proteins and expression of both highand low-affinity binding on human lymphoid cells
11. Recombinant interleukin-12 cures mice infected with Leishmania major
12. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha-beta-T-cell-receptor transgenic system
13. + alpha-beta TCR trangenic T cells is macrophage dependent
14. + T cells through IL-12 produced by Listeria-induced macrophages
15. T cell genetic background determines default T helper phenotype development in vitro
16. Interleukin 12 signalling in Thi cells involves tyrosine phosphorylation of Stat3 and Stat4
17. Tyrosine phosphorylation of DNA binding proteins by multiple cytokines
18. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells
19. Expression of high affinity receptors for murin interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells
20. + T cells from alpha β TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-gamma production is IFN-gamma-dependent
21. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties
22. Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and-gamma signal transduction pathways
23. + TCR-lo thymocytes in vivo
24. Production of a monoclonal antibody to and molecular characterization of B-cell stimulatoryfactor-1
25. Up-regulation on interleukin 4/B-cell stimulatory factor 1 receptor expression
26. Stability of Th1 and Th2 populations
27. + T cells curing initiation of infection
28. + T cells
29. + T cells requires the coordinate action of interleukin-12 and interferongamma and is inhibited by transforming growth factor-beta
30. IL-12: initiation cytokine for cell-mediated immunity
31. The role of T-cell subsets and cytokines in the regulation of infection
32. + T-cell subsets in the regulation of parasite immunity and disease
33. + T cells
34. + T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming
35. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
36. IL-4 directs the development of Th2-like helper effectors
37. Resolution of cutaneous Leishmaniasis: interleukin-12 initiates a protective T helper type 1 immune response
38. Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc
39. Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice: reversal by IFN-gamma
40. The importance of Th2 cytokines in protective immunity to nematodes
41. A protein tyrosine kinase in the interferon alpha/beta signaling pathway
42. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter
43. Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway
44. JAK2 associates with the erythropoetin receptor and is tyrosine phosphorylated and activated following stimulation with ertyhropoetin
45. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
46. Stat3 and Stat4: members of the family of signal transducers and activators of transcription