Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

Cell

Volumn 81, Issue 7, 1995, Pages 1147-1157

  Minden, Audrey ^a   Lin, Anning ^a   Claret, François Xavier ^a   Abo, Arie ^b   Karin, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ONYX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL STRAIN 3T3; CELL STRAIN COS1; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HELA CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

3T3 CELLS; ANIMAL; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CDC42 GTP-BINDING PROTEIN; CELL CYCLE PROTEINS; CELL LINE; CERCOPITHECUS AETHIOPS; COMPARATIVE STUDY; ENZYME ACTIVATION; GENE EXPRESSION; GENES, JUN; GENES, RAS; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; HELA CELLS; HUMAN; MICE; PROTO-ONCOGENE PROTEINS C-JUN; RAC GTP-BINDING PROTEINS; RECOMBINANT PROTEINS; RHOA GTP-BINDING PROTEIN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 0029070887     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(05)80019-4     Document Type: Article

References (65)

1. Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated proteinkinases
2. Cdc42 and Cdc43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae
3. The hematopoietically expressed Vav proto-oncogene shares homologywith the Dbl G DP-GTP exchange factor, the Bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization
4. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
5. Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins
6. Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related geneRSR1
7. Emerging concepts in the Ras superfamily of GTP-binding proteins
8. The GTPase superfamily: a conserved switch for diverse cell functions
9. Epidermal growth factor regulates p21- through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
10. Cooperative interaction of S. pombe proteins required for mating and morphogenesis
11. A yeast gene (BME1) necessary for cell polarization whose product contains two SH3 domains
12. How are MAP kinases regulated?
13. Activation of MAP kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
14. STE20-like protein kinases are required for localized cell growth and cytokinesis in budding yeast
15. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
16. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
17. ras in activation of extracellular regulated kinase 2
18. rac
19. The ras superfamily of small GTP-binding proteins
20. The pathway to signal achievement
21. Isolation of a new human oncogene from a diffuse Bcell lymphoma
22. Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins
23. Vesicle fusion from yeast to man
24. An osmosensing signal transduction pathway in mammalian cells
25. Transcription factor ATF2 regulation by the JNK signal transduction pathway
26. Ras-related proteins
27. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
28. Catalysis of guanine nucleotide exchange on the Cdc42Hs protein by the dbl oncogene product
29. Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product
30. MAP kinase pathways in yeast: for mating and more
31. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
32. Transcriptional regulation by extracellular signals: mechanisms and specificity
33. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts
34. The stress-activated protein kinase subfamily of c-Jun kinases
35. Ras-dependent growth factor regulation of MEK kinase in PC12 cells
36. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
37. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
38. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
39. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
40. Science
41. A brain serinelthreonine protein kinase activated by Cdc42 and Raci
42. Transformation of mammalian cells by constitutively active MAP kinase kinase
43. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellularsignai-regulated kinase activation
44. A novel serine kinase activated by Rac11CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20
45. A role for Rac in Tiami-induced membrane ruffling and invasion
46. Oncogene Ect2 is related to regulators of small GTP-binding proteins
47. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK
48. Regulation and function of the Rho subfamily of small GTPases
49. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
50. An essential role for Rac in Ras transformation. Nature 374, 457-459. Ridley, A. J. (1994). Membrane ruffling and signal transduction
51. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
52. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
53. Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade
54. Mechanisms of intracellular protein transport
55. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
56. The biochemical basis of the NADPH oxidase of phagocytes
57. Activation of Raf as a result of recruitment of the plasma membrane
58. JNK is involved in signal integration during costimulation of T lymphocytes
59. SRα promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type I long terminal repeat
60. Ras is essential for nerve growth factor and phorbol ester induced tyrosine phosphorylation of MAP kinases
61. Signal transduction by lymphocyte antigen receptors
62. Multiple Ras functions can contribute to mammalian cell transformation
63. Ras mediates nerve growth factor receptor modulation of three signal transducing protein kinases: MAP kinase, Raf-1, and Rsk
64. Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac
65. Activation of stress-activated protein kinase by MEKKI phosphorylation of its activator SEK1