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Volumn 7, Issue 6, 1995, Pages 891-904

CD28 ligands CD80 (B7-1) and CD86 (B7-2) induce long-term autocrine growth of CD4+ T cells and induce similar patterns of cytokine secretion in vitro

Author keywords

B7; CD28; CD80; CD86; Co stimulation; Cytokine; T helper

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5;

EID: 0029069364     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/7.6.891     Document Type: Article
Times cited : (145)

References (65)
  • 1
    • 0026541544 scopus 로고
    • The two-signal model of lymphocyte activation twenty-one years later
    • Bretscher, P. 1992. The two-signal model of lymphocyte activation twenty-one years later. Immunol. Today 13:74.
    • (1992) Immunol. Today , vol.13 , pp. 74
    • Bretscher, P.1
  • 3
    • 0027403299 scopus 로고
    • The role of the CD28 receptor during T cell responses to antigen
    • Linsley, P. S. and Ledbetter, J. A. 1993. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11:191.
    • (1993) Annu. Rev. Immunol , vol.11 , pp. 191
    • Linsley, P.S.1    Ledbetter, J.A.2
  • 4
    • 0027087331 scopus 로고
    • Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy
    • Schwartz, R H. 1992. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71:1085.
    • (1992) Cell , vol.71 , pp. 1085
    • Schwartz, R.H.1
  • 5
    • 0028237348 scopus 로고
    • CD28-B7 interactions in T-cell activation
    • Allison, J. P. 1994. CD28-B7 interactions in T-cell activation. Curr. Opin Immunol. 6:414.
    • (1994) Curr. Opin Immunol , vol.6 , pp. 414
    • Allison, J.P.1
  • 6
    • 0024444165 scopus 로고
    • B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells
    • Freeman, G. J., Freedman, A. S., Segil, J. M, Lee, G., Whitman, J. F. and Nadler, L. M. 1989. B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells, J. Immunol 143.2714.
    • (1989) J. Immunol , vol.143 , pp. 2714
    • Freeman, G.J.1    Freedman, A.S.2    Segil, J.M.3    Lee, G.4    Whitman, J.F.5    Nadler, L.M.6
  • 9
    • 0026543202 scopus 로고
    • Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex
    • Resier, H., Freeman, G. J, Razi-Vtolf, Z., Gimmi, C. D, Benacerraf, B and Nadler, L. M. 1992. Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex Proc. Natl Acad. Sci. USA 89.271.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 271
    • Resier, H.1    Freeman, G.J.2    Razi-Vtolf, Z.3    Gimmi, C.D.4    Benacerraf, B.5    Nadler, L.M.6
  • 10
  • 11
    • 0027415096 scopus 로고
    • A novel monoclonal antibody (FUN-1) identifies an activation antigen in cells of the B-cell lineage and Reed-Sternberg cells
    • Nozawa, Y, Wachi, E, Tominaga, K., Abe, M. and Wakasa, H. 1993 A novel monoclonal antibody (FUN-1) identifies an activation antigen in cells of the B-cell lineage and Reed-Sternberg cells J. Pathol 169 309.
    • (1993) J. Pathol , vol.169 , pp. 309
    • Nozawa, Y.1    Wachi, E.2    Tominaga, K.3    Abe, M.4    Wakasa, H.5
  • 12
    • 0025950146 scopus 로고
    • Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes- a potential mechanism for amplification of T cell activation through the CD28 pathway
    • Freedman, A. S, Freeman, G. J, Rhynhart, K. and Nadler, L. M 1991 Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes- a potential mechanism for amplification of T cell activation through the CD28 pathway Cell Immunol. 137.429.
    • (1991) Cell Immunol , vol.137 , pp. 429
    • Freedman, A.S.1    Freeman, G.J.2    Rhynhart, K.3    Nadler, L.M.4
  • 13
    • 0028337459 scopus 로고
    • Comparative analysis of B7-1 and B7-2 costimulatory ligands: Expression and function
    • Hathcock, K S., Laszlo, G., Pucillo, C., Unsley, P and Hodes, R. J. 1994. Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J. Exp. Med. 180 631.
    • (1994) J. Exp. Med , vol.180 , pp. 631
    • Hathcock, K.S.1    Laszlo, G.2    Pucillo, C.3    Unsley, P.4    Hodes, R.J.5
  • 14
    • 0028179886 scopus 로고
    • Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells
    • Larsen, C. P., Ritchie, S C., Hendrix, R., Linsley, P. S., Hathcock, K S, Hodes, R J., Lowry, R. P. and Pearson, T C. 1994. Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells J Immunol. 152:5208.
    • (1994) J Immunol , vol.152 , pp. 5208
    • Larsen, C.P.1    Ritchie, S.C.2    Hendrix, R.3    Linsley, P.S.4    Hathcock, K.S.5    Hodes, R.J.6    Lowry, R.P.7    Pearson, T.C.8
  • 15
    • 0028181231 scopus 로고
    • IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2
    • Stack, R. M., Lenschow, D. J., Gray, G. S., Bluestone, J A and Fitch, F. W. 1994 IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2. J. Immunol. 152:5723.
    • (1994) J. Immunol , vol.152 , pp. 5723
    • Stack, R.M.1    Lenschow, D.J.2    Gray, G.S.3    Bluestone, J.A.4    Fitch, F.W.5
  • 20
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann, T. R. and Coffman, R. L. 1989 TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7-145.
    • (1989) Annu. Rev. Immunol , pp. 7-145
    • Mosmann, T.R.1    Coffman, R.L.2
  • 21
    • 0028288179 scopus 로고
    • Lymphokine production by human T cells in disease states
    • Romagnani, S. 1994. Lymphokine production by human T cells in disease states. Annu Rev. Immunol. 12:227.
    • (1994) Annu Rev. Immunol , vol.12 , pp. 227
    • Romagnani, S.1
  • 22
    • 0027177008 scopus 로고
    • IL-12. initiation cytokine for cell-mediated immunity
    • Scott, P. 1993. IL-12. initiation cytokine for cell-mediated immunity. Science 260:496.
    • (1993) Science , vol.260 , pp. 496
    • Scott, P.1
  • 25
    • 0027192884 scopus 로고
    • Antigen presenting cell-derived co-stimulatory signals can selectively regulate IL-2 and IL-4 production from a ThO cell hybridoma
    • Fox, B. S. 1993. Antigen presenting cell-derived co-stimulatory signals can selectively regulate IL-2 and IL-4 production from a ThO cell hybridoma. Int. Immunol. 5:323.
    • (1993) Int. Immunol , vol.5 , pp. 323
    • Fox, B.S.1
  • 26
    • 0028233727 scopus 로고
    • Keratinocyte-derived T cell costimulation induces preferential production of IL-2 and IL-4 but not IFN-gamma
    • Goodman, R. E, Nestle, F., Naidu, Y. M., Green, J. M., Thompson, C. B., Nickoloff, B. J. and Turka, L. A. 1994. Keratinocyte-derived T cell costimulation induces preferential production of IL-2 and IL-4 but not IFN-gamma. J. Immunol. 152:5189.
    • (1994) J. Immunol , vol.152 , pp. 5189
    • Goodman, R.E.1    Nestle, F.2    Naidu, Y.M.3    Green, J.M.4    Thompson, C.B.5    Nickoloff, B.J.6    Turka, L.A.7
  • 27
    • 0028123444 scopus 로고
    • CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interleukin gamma production
    • Seder, R. A., Germain, R. N., Linsley, P. S. and Paul, W. E. 1994. CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interleukin gamma production. J Exp. Med 179.299.
    • (1994) J Exp. Med , vol.179 , pp. 299
    • Seder, R.A.1    Germain, R.N.2    Linsley, P.S.3    Paul, W.E.4
  • 29
    • 0027397169 scopus 로고
    • Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1
    • Tan, P., Anasetti, C., Hansen, J. A., Melrose, J., Brunvand, M, Bradshaw, J., Ledbetter, J. A. and Linsley, P. S 1993. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J Exp. Med 177 165.
    • (1993) J Exp. Med , vol.177 , pp. 165
    • Tan, P.1    Anasetti, C.2    Hansen, J.A.3    Melrose, J.4    Brunvand, M.5    Bradshaw, J.6    Ledbetter, J.A.7    Linsley, P.S.8
  • 31
    • 0028365499 scopus 로고
    • Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice
    • Guerder, S, Picarella, D. E., Unsley, P S and Flavell, R. A. 1994. Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice Proc. Natl Acad. Sci. USA 91:5138.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 5138
    • Guerder, S.1    Picarella, D.E.2    Unsley, P.S.3    Flavell, R.A.4
  • 32
    • 0023637951 scopus 로고
    • T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression
    • June, C H., Ledbetter, J. A, Gillespie, M M., Lindsten, T. and Thompson, C. B. 1987. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol Cell. Biol. 7:4472.
    • (1987) Mol Cell. Biol , vol.7 , pp. 4472
    • June, C.H.1    Ledbetter, J.A.2    Gillespie, M.M.3    Lindsten, T.4    Thompson, C.B.5
  • 33
    • 0024317711 scopus 로고
    • Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes
    • June, C. H, Ledbetter, J. A., Lindsten, T. and Thompson, C B. 1989. Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes J. Immunol. 143:153.
    • (1989) J. Immunol , vol.143 , pp. 153
    • June, C.H.1    Ledbetter, J.A.2    Lindsten, T.3    Thompson, C.B.4
  • 35
    • 0028122223 scopus 로고
    • The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B-lymphocytes is the CD86 differentiation antigen
    • Engel, P., Gribben, J. G., Freeman, G J., Zhou, L. J., Nozaawa, Y., Abe, M, Nadler, L. M., Wakasa, H. and Tedder, T. F. 1994 The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B-lymphocytes is the CD86 differentiation antigen Blood 84.1402.
    • (1994) Blood , vol.84 , pp. 1402
    • Engel, P.1    Gribben, J.G.2    Freeman, G.J.3    Zhou, L.J.4    Nozaawa, Y.5    Abe, M.6    Nadler, L.M.7    Wakasa, H.8    Tedder, T.F.9
  • 36
    • 0026470618 scopus 로고
    • Co-stimulation of murine CD4 T cell growth: Cooperation between B7 and heat-stable antigen
    • Liu, Y., Jones, B., Brady, W., Janeway, C. A, Jr and Linsley, P. S. 1992 Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen. Eur. J. Immunol. 22:2855.
    • (1992) Eur. J. Immunol , vol.22 , pp. 2855
    • Liu, Y.1    Jones, B.2    Brady, W.3    Janeway, C.A.4    Linsley, P.S.5
  • 38
    • 0028215960 scopus 로고
    • Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7
    • Damle, N. K., Klussman, K., Leytze, G., Myrdal, S., Aruffo, A., Ledbetter, J. A. and Linsley, P. S. 1994. Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7. J. Immunol. 152:2686.
    • (1994) J. Immunol , vol.152 , pp. 2686
    • Damle, N.K.1    Klussman, K.2    Leytze, G.3    Myrdal, S.4    Aruffo, A.5    Ledbetter, J.A.6    Linsley, P.S.7
  • 41
    • 0028328349 scopus 로고
    • + T cells by delivery of the B7 costimulatory signal on bystander antigen-presenting cells (/rans-costimulation)
    • + T cells by delivery of the B7 costimulatory signal on bystander antigen-presenting cells (/rans-costimulation). Eur. J. Immunol. 24:859.
    • (1994) Eur. J. Immunol , vol.24 , pp. 859
    • Ding, L.1    Shevach, E.M.2
  • 42
    • 0025754834 scopus 로고
    • Monokine production by human T cells; IL-1 alpha production restricted to memory T cells
    • van Kooten, C., Rensink, I., Pascual-Salcedo, D., van Oers, R. and Aarden, L. 1991. Monokine production by human T cells; IL-1 alpha production restricted to memory T cells J. Immunol 146:2654.
    • (1991) J. Immunol , vol.146 , pp. 2654
    • van Kooten, C.1    Rensink, I.2    Pascual-Salcedo, D.3    van Oers, R.4    Aarden, L.5
  • 43
    • 0024389426 scopus 로고
    • Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor-mediated activation
    • Sanders, M. E, Makgoba, M. W, June, C. H., Young, H A and Shaw, S. 1989. Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor-mediated activation. Eur. J. Immunol. 19.803.
    • (1989) Eur. J. Immunol , vol.19 , pp. 803
    • Sanders, M.E.1    Makgoba, M.W.2    June, C.H.3    Young, H.A.4    Shaw, S.5
  • 44
    • 0026537347 scopus 로고
    • CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
    • Harding, F. A., McArthur, J. G., Gross, J. A, Raulet, D. H. and Allison, J P. 1992. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
    • (1992) Nature , vol.356 , pp. 607
    • Harding, F.A.1    McArthur, J.G.2    Gross, J.A.3    Raulet, D.H.4    Allison, J.P.5
  • 45
    • 0027431890 scopus 로고
    • CD28-induced costimulation of T-helper type-2 cells mediated by induction of responsiveness to interleukin-4
    • McArthur, J. G. and Raulet, D. H. 1993. CD28-induced costimulation of T-helper type-2 cells mediated by induction of responsiveness to interleukin-4. J. Exp. Med. 178:1645.
    • (1993) J. Exp. Med , vol.178 , pp. 1645
    • McArthur, J.G.1    Raulet, D.H.2
  • 47
    • 0025963594 scopus 로고
    • Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation
    • Linsley, P S., Brady, W., Grosmaire, L., Aruffo, A., Damle, N. K. and Ledbetter, J. A 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 173:721.
    • (1991) J. Exp. Med , vol.173 , pp. 721
    • Linsley, P.S.1    Brady, W.2    Grosmaire, L.3    Aruffo, A.4    Damle, N.K.5    Ledbetter, J.A.6
  • 48
    • 0026785932 scopus 로고
    • Regulation of interleukin-4 production in human mononuclear cells
    • Holter, W., Majdic, O., Kalthoff, F. S. and Knapp, W. 1992. Regulation of interleukin-4 production in human mononuclear cells. Eur. J. Immunol. 22.2765.
    • (1992) Eur. J. Immunol , vol.22 , pp. 2765
    • Holter, W.1    Majdic, O.2    Kalthoff, F.S.3    Knapp, W.4
  • 49
    • 0026509257 scopus 로고
    • Interleukin (IL)-4 production by human T cells: Differential regulation of IL-4 vs. IL-2 production
    • van der Pouw-Kraan, T, van Kooten, C., Rensink, I and Aarden, L. 1992. Interleukin (IL)-4 production by human T cells: differential regulation of IL-4 vs. IL-2 production. Eur. J. Immunol 22.1237.
    • (1992) Eur. J. Immunol , vol.22 , pp. 1237
    • van der Pouw-Kraan, T.1    van Kooten, C.2    Rensink, I.3    Aarden, L.4
  • 50
    • 0028303170 scopus 로고
    • Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells
    • Kubin, M., Kamoun, M. and Trinchieri, G. 1994. Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 180:211.
    • (1994) J. Exp. Med , vol.180 , pp. 211
    • Kubin, M.1    Kamoun, M.2    Trinchieri, G.3
  • 51
  • 53
    • 0027417789 scopus 로고
    • CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: Analysis of early and late activation events
    • Nunös, J., Klasen, S., Ragueneau, M., Pavon, C., Couez, D., Mawas, C., Bagnasco, M. and Olive, D 1993. CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events. Int. Immunol. 5 311.
    • (1993) Int. Immunol , vol.5 , pp. 311
    • Nunös, J.1    Klasen, S.2    Ragueneau, M.3    Pavon, C.4    Couez, D.5    Mawas, C.6    Bagnasco, M.7    Olive, D.8
  • 54
    • 0028169441 scopus 로고
    • The role of p21 ras in CD28 signal transduction’ triggering of CD28with antibodies, but not the ligand B7-1, activates p21 ras
    • Nunes, J. A., Collette, Y., Truneh, A, Olive, D. and Cantrell, D. A. 1994 The role of p21 ras in CD28 signal transduction’ triggering of CD28with antibodies, but not the ligand B7-1, activates p21 ras. J. Exp. Med. 180:1067.
    • (1994) J. Exp. Med , vol.180 , pp. 1067
    • Nunes, J.A.1    Collette, Y.2    Truneh, A.3    Olive, D.4    Cantrell, D.A.5
  • 56
    • 0026691651 scopus 로고
    • CD28-mduced T cell activation Evidence for a protein-tyrosine kinase signal transduction pathway
    • Lu, Y., Granelli-Piperno, A., Bjorndahl, J. M., Phillips, C A and Trevillyan, J. M. 1992. CD28-mduced T cell activation Evidence for a protein-tyrosine kinase signal transduction pathway. J. Immunol 149:24.
    • (1992) J. Immunol , vol.149 , pp. 24
    • Lu, Y.1    Granelli-Piperno, A.2    Bjorndahl, J.M.3    Phillips, C.A.4    Trevillyan, J.M.5
  • 57
    • 0026434554 scopus 로고
    • Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand
    • Evavold, B. D. and Allen, P. M. 1991 Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252.1308.
    • (1991) Science , vol.252 , pp. 1308
    • Evavold, B.D.1    Allen, P.M.2
  • 60
    • 0028281040 scopus 로고
    • Monocytes provide a novel costimulatory signal to T cells that is not mediated by the CD28/B7 interaction
    • Johnson, J. G. and Jenkins, M. K 1994. Monocytes provide a novel costimulatory signal to T cells that is not mediated by the CD28/B7 interaction. J. Immunol 152:429.
    • (1994) J. Immunol , vol.152 , pp. 429
    • Johnson, J.G.1    Jenkins, M.K.2
  • 61
    • 0028125972 scopus 로고
    • Evidence for differential intracellular signaling via CD4 and CD8 molecules
    • Ravichandran, K. S. and Burakoff, S. J. 1994. Evidence for differential intracellular signaling via CD4 and CD8 molecules. J. Exp. Med. 179:727.
    • (1994) J. Exp. Med , vol.179 , pp. 727
    • Ravichandran, K.S.1    Burakoff, S.J.2
  • 62
    • 0025286903 scopus 로고
    • Hyporesponsiveness of naive (CD45RA+) human T cells to multiple receptor-mediated stimuli but augmentation of responses by co-stimuli
    • Horgan, K. J, van Seventer, G. A., Shimizu, Y. and Shaw, S. 1990 Hyporesponsiveness of naive (CD45RA+) human T cells to multiple receptor-mediated stimuli but augmentation of responses by co-stimuli. Eur. J. Immunol. 20.1111.
    • (1990) Eur. J. Immunol , vol.20 , pp. 1111
    • Horgan, K.J.1    van Seventer, G.A.2    Shimizu, Y.3    Shaw, S.4
  • 64
    • 0027135532 scopus 로고
    • Human naive and memory T-helper cells display distinct adhesion properties to ICAM-1, LFA-3 and B7 molecules
    • Parra, E., Wingren, A. G, Hedlund, G., Sjogren, H. O., Kalland, T., Sansom, D. and Dohlsten, M. 1993. Human naive and memory T-helper cells display distinct adhesion properties to ICAM-1, LFA-3 and B7 molecules. Scand. J. Immunol. 38:508.
    • (1993) Scand. J. Immunol , vol.38 , pp. 508
    • Parra, E.1    Wingren, A.G.2    Hedlund, G.3    Sjogren, H.O.4    Kalland, T.5    Sansom, D.6    Dohlsten, M.7
  • 65
    • 0028316562 scopus 로고
    • Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells
    • Croft, M., Bradley, L. M. and Swain, S. L. 1994. Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J. Immunol. 152.2675.
    • (1994) J. Immunol , vol.152 , pp. 2675
    • Croft, M.1    Bradley, L.M.2    Swain, S.L.3


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