The three-dimensional structure of NAD(P)H:quinone reductase a flavoprotein involved in cancer chemoprotection and chemotherapy: Mechanism of the two-electron reduction

Proceedings of the National Academy of Sciences of the United States of America

Volumn 92, Issue 19, 1995, Pages 8846-8850

  Li, Rongbao ^a   Bianchet, Mario A ^a   Talalay, Paul ^a   Amzel, L Mario ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Flavin; X ray diffraction

Indexed keywords

BACTERIA (MICROORGANISMS); ANIMALIA;

DUROQUINONE; FLAVINE ADENINE NUCLEOTIDE; FLAVODOXIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; CANCER PREVENTION; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; RAT; REDUCTION; X RAY DIFFRACTION;

AMINO ACID SEQUENCE; ANIMAL; BENZOQUINONES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FLAVIN-ADENINE DINUCLEOTIDE; FLAVOPROTEINS; LIVER; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; NAD(P)H DEHYDROGENASE (QUINONE); NADP; NEOPLASMS; OXIDATION-REDUCTION; PRODRUGS; RATS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TRIAZINES;

EID: 0029068515     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.92.19.8846     Document Type: Article

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