pl6 Gene Alterations in Nasopharyngeal Carcinoma

Cancer Research

Volumn 55, Issue 10, 1995, Pages 2039-2043

  Lo, Kwok Wai ^a   Huang, Dolly P ^a   Lau, Kin Mang ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER GENETICS; CARCINOGENESIS; CHROMOSOME 9P; GENE DELETION; GENE MUTATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

CHROMOSOMES, HUMAN, PAIR 9; GENE DELETION; GENES, TUMOR SUPPRESSOR; HOMOZYGOTE; HUMAN; MUTATION; NASOPHARYNGEAL NEOPLASMS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; SEQUENCE ANALYSIS, DNA; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0029066731     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Muir, C., Waterhouse, J., Mack, T., Powell, J., and Whelan, S. Cancer Incidence in Five Continents, Vol. 5. IARC Scientific Publication No. 88. Lyon, France: International Agency for Research on Cancer, 1987.
2. Huang, D. P. Epidemiology and aetiology. In: C. A. van Hasselt and A. G. Gibb (eds.), Nasopharyngeal Carcinoma, pp. 23-35. Hong Kong: The Chinese University Press, 1991.
3. Spruck, C. H., III, Tsao, Y. C., Huang, D. P., Yang, A. S., Rideout, W. M., III, Gonzalwz-Zulueta, M., Choi, P., Lo, K.-W., Yu, M. C., and Jones, P. A. Absence of p53 gene mutations in primary nasopharyngeal carcinomas. Cancer Res., 52: 4787-4790, 1992.
4. Sun, Y., Hegamyer, G., and Colburn, N. H. Nasopharyngeal carcinoma shows no detectable retinoblastoma susceptibility gene alterations. Oncogene, 8: 791-795, 1993.
5. Huang, D. P., Ho, J. H. C., Chan, W. K., Lau, W. H., and Lui, M. Cytogenetics of undifferentiated nasopharyngeal carcinoma xenografts from southern Chinese. Int. J. Cancer, 43: 936-939, 1989.
6. Huang, D. P., Lo, K.-W., Choi, P. H. K., Ng, A. Y. T., Tsao, S.-Y., Yiu, G. K. C., and Lee, J. C. K. Loss of heterozygosity on the short arm of chromosome 3 in nasopharyngeal carcinoma. Cancer Genet. Cytogenet., 54: 91-99, 1991.
7. Choi, P. H. K., Suen, M. W. M., Huang, D. P., Lo, K.-W., and Lee, J. C. K. Nasopharyngeal carcinoma: genetic changes, Epstein-Barr virus infection, or both, a clinical and molecular study of 36 patients. Cancer (Phila.), 72: 2873-2878, 1993.
8. Huang, D. P., Lo, K.-W., van Hasselt, C. A., Woo, J. K. S., Choi, P. H. K., Leung, S. F., Cheung, S. T., Cairns, P., Sidransky, D., and Lee, J. C. K. A region of homozygous deletion on chromosome 9p21-22 in primary nasopharyngeal carcinoma. Cancer Res., 54: 4003-4006, 1994.
9. Kamb, A., Gruis, N., Feldhaus, J., Liu, Q., Harshnman, K., Tavtigian, S., Stockert, E., Day, R., Johnson, B., and Skolnick, M. A cell cycle regulator potentially involved in genesis of many tumor types. Science (Washington DC), 264: 436-439, 1994.
10. Nobori, T., Miura, K., Wu, D. J., Lois, A., Takabayashi, K., and Carson, D. A. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature (Lond.), 368: 753-756, 1994.
11. Serrano, M., Hannon, G. J., and Beach, D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK 4. Nature (Lond.), 366: 704-707, 1993.
12. Zhang, S.-Y., Klein-Szanto, A. J. P., Sauter, E. R., Shafarenko, M., Mitsunaga, S., Nobori, T., Carson, D. A., Ridge, J. A., and Goodrow, T. L. Higher frequency of alterations in the pl6/CDKN2 gene in squamous cell carcinomas cell lines than in primary tumors of the head and neck. Cancer Res., 54: 5050-5053, 1994.
13. Zhou, X., Tannin, L., Yin, J., Jiang, H. Y., Suzuki, H., Rhyu, M. G., Abraham, J. M., and Meltzer, S. J. The MTS1 gene is frequently mutated in primary human esophageal tumors. Oncogene, 9: 3737-3741, 1994.
14. Mori, T., Miura, K., Aoki, T., Nishihira, T., Mori, S., and Nakamura, Y. Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-depend-ent kinase 4 inhibitor) gene in esophageal carcinoma. Cancer Res., 54: 3396-3397, 1994.
15. Cairns, P., Mao, L., Merlo, A., Lee, D. J., Schwab, D., Eby, Y., Tokino, K., van der Riet, P., Blaugrund, J., and Sidransky, D. Rates of pl6 (MTS1) mutations in primary tumors with 9p loss. Science (Washington DC), 265: 415-416, 1994.
16. Spruck, C. H., Gonzalez-Zulueta, M., Shibata, A., Simoneau, A. R., Lin, M. F., Gonzales, F., Tsai, Y. C., and Jones, P. A. p16 gene in uncultured tumors. Nature (Lond.), 370: 183-184, 1994.
17. Okamoto, A., Demetrick, D. J., Spillare, E. A., Hagiwara, K., Hussain, S. P., Bennett, W. P., Forrester, K., Gerwin, B., Serrano, M., Beach, D. H., and Harris, C. C. Mutations and altered expression of p16INK4 in human cancer. Proc. Natl. Acad. Sci, USA., 91: 11045-11049, 1994.
18. Walker, D. G., Duan, W., Popovic, E. A., Kaye, A. H., Tomlinson, F. H., and Lavin M. Homozyous deletions of the multiple tumor suppressor gene 1 in the progression of human astrocytomas. Cancer Res., 55: 20-23, 1995.
19. Washimi, O., Nagatake, M., Osada, H., Ueda, R., Koshikawa, T., Seki, T., Takahashi, T., and Takahashi, T. In vivo occurrence of pl6 (MTS1) and pl5 (MTS2) alterations preferentially in non-small cell lung cancers. Cancer Res., 55, 514-517, 1995.
20. Cheng, J. Q., Jhanwar, S. C., Klein, W. M., Bell, D. W., Lee, W.-C., Altomare, D. A., Nobori, T., Olopade, O. I., Buckler, A. J., and Testa, J. R. pl6 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma. Cancer Res., 54: 5547-5551, 1994.
21. Jen, J., Harper, J. W., Bigner, S. H., Bigner, D. D., Papadopoulos, N., Markowitz, S., Willson, J. K. V., Kinzler, K. W., and Vogelstein, B. Deletion of p16 and p15 genes in brain tumors. Cancer Res., 54: 6353-6358, 1994.
22. Huang, D. P., Lau, W. H., Lung, M., Saw, D., and Lui, M. Establishment and characterization of undifferentiated nasopharyngeal carcinoma xenografts from southern Chinese. J. Exp. Clin. Cancer Res., 7: 48, 1988.
23. Huang, D. P., Ho, J. H. C., Poon, Y. F., Chew, E. C., Saw, D., Liu, M., Li, C. L., Mak, L. S., Lai, S. H., and Lau, E. H. Establishment of a cell line (NPC/HK1) from a differentiated squamous carcinomas of the nasopharynx. Int. J. Cancer, 26:127-132,1980.
24. Gu, S. Y., Tang, W. P., Zeng, Y., Zhao, M. L., Zhao, E. W. P., Deng, W. H., and Li, K. An epithelial cell line established from poorly differentiated nasopharyngeal carcinoma (in Chinese). Chin. J. Cancer, 2: 70-72, 1983.
25. Chinese Academy of Medical Sciences and Chungshan Medical College. Establishment of an epithelial cell line and fusiform cell line from a patient with nasopharyngeal carcinomas (in Chinese). Sci. Sin., 21: 113-118, 1978.
26. Hussussian, C. J., Struewing, J. P., Goldstein, A. M., Higgins, P. A. T., Ally, D. S., Sheahan, M. D., Clark, W. H., Jr., Tucker, M. A., and Dracopoli, N. C. Germline pl6 mutations in familial melanoma. Nat. Genet., 8: 15-21, 1994.
27. Mok, S. H., Lo, K.-W., and Tsao, S. W. Direct cycle sequencing of mutated alleles detected by PCR single-strand conformation polymorphism analysis. Biotechniques, 14: 790-794, 1992.
28. Ohta, M., Nagai, H., Shimizu, M., Rasio, D., Berd, D., Mastrangelo, M., Singh, A. D., Shields, J. A., Shields, C. L., Croce, C. M., and Huebner, K. Rarity of somatic and germline mutations of the cyclin-dependent kinase 4 inhibitor gene, CDK41, in melanoma. Cancer Res., 54: 5269-5272, 1994.
29. Caldas, C., Hahn, S. A., de Costa, L. T., Redston, M. S., Schutte, M., Seymour, A. B., Weinstein, C. L., Hruban, R. H., Yeo, C. J., and Kern, S. E. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat. Genet., 8: 27-32, 1994.
30. Hannon, G. J., and Beach, D. p15INK4B is a potential effector of TGF-0-induced cell cycle arrest. Nature (Lond.), 371: 257-261, 1994.
31. Otterson, G. A., Kratzke, R. A., Coxon, A., Kim, Y. W., and Kaye, F. J. Absence of p16INK4 protgiu js restricted to the subset of lung cancer lines that retains wildtype RB. Oncogene, 9: 3375-3378, 1994.
32. He, J., Allen, J. H., Collins, V. P., Allalunis-Turner, M. J., Godbout, R., Day, R. S. M., and James, C. D. CDK4 amplification is an alternative mechanism to pl6 gene homozygous deletion in glioma cell lines. Cancer Res., 54: 5804-5807,1994.
33. Callender, T., Elnaggar, A. K., Lee, M. S., Frankenthaler, R., Luna, H. A., and Batsakis, J. G. PRAD-1 (CCND1) cyclin Dl oncogene amplification in primary head and neck squamous cell carcinoma. Cancer (Phila.), 74: 152-158, 1994.