Differentiation-regulated serine phosphorylation of STAT1 promotes GAF activation in macrophages

Molecular and Cellular Biology

Volumn 15, Issue 7, 1995, Pages 3579-3586

  Eilers, Andreas ^a   Georgellis, Dimitris ^a   Klose, Birgit ^a   Schindler, Chris ^b   Ziemiecki, Andrew ^c   Harpur, Ailsa G ^d   Wilks, Andrew F ^d   Decker, Thomas ^a  

^a Vienna Biocenter   (Austria)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c UNIVERSITY OF BERN   (Switzerland)

^d ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; PHOSPHATASE; TRANSCRIPTION FACTOR;

ARTICLE; DIMERIZATION; DNA BINDING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MACROPHAGE; MACROPHAGE ACTIVATION; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0029066128     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.15.7.3579     Document Type: Article

References (42)

1. Adams, D. O., and T. A. Hamilton. 1984. Molecular interactions in macrophage activation. Annu. Rev. Immunol. 2:283-318.
2. Barahmand-pour, F., A. Meinke, A. Eilers, F. Gouilleux, B. Groner, and T. Decker. 1995. Colony-stimulating factors and inteferon-γ activate a protein related to MGF-Stat 5 to cause formation of the differentiation-induced factor in myeloid cells. FEBS Lett. 360:29-33.
3. Boyle, M., P. van der Geer, and T. Hunter. 1991. Phosphopeptide mapping and phospho-aminoacid analysis by two dimensional separation on thin layer cellulose plates. Methods Enzymol. 201(Part B):110-149.
4. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
5. Cohen, P. 1989. The structure and regulation of protein phosphatases. Annu. Rev. Biochem. 58:453-508.
6. Dalton, D. K., S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects in mice with disrupted interferon-γ genes. Science 259:1739-1742.
7. Darnell, J. E., Jr., I. M. Kerr, and G. R. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421.
8. Decker, T., D. J. Lew, J. Mirkovitch, and J. E. Darnell, Jr. 1991. Cytoplasmic activation of GAF, an IFN-γ-regulated DNA-binding factor. EMBO J. 10: 927-932.
9. De Maeyer, E., and J. De Maeyer-Guignard (ed.). 1988. Interferons and other regulatory cytokines. John Wiley & Sons, New York.
10. Eilers, A., M. Baccarini, F. Horn, R. A. Hipskind, C. Schindler, and T. Decker. 1994. A factor induced by differentiating signals in cells of the macrophage lineage binds to the gamma interferon activation site. Mol. Cell. Biol. 14:1364-1373.
11. Eilers, A., and T. Decker. Unpublished results.
12. Eilers, A., D. Seegert, C. Schindler, M. Baccarini, and T. Decker. 1993. The response of the gamma interferon activation factor (GAF) is under developmental control in cells of the macrophage lineage. Mol. Cell. Biol. 13: 3245-3254.
13. Ferrero, D., and G. Rovera. 1991. Human leukemic cell lines. Clin. Haematol. 13:461-473.
14. Harris, P., and P. Ralph. 1985. Human leukemic models of myelomonocytic development: a review of the HL 60 and U937 cell lines. J. Leukocyte Biol. 37:403-422.
15. Huang, S., W. Hendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamijo, J. Vilcek, R. M. Zinkernagel, and M. Aguet. 1993. Immune response in mice that lack the interferon-γ receptor. Science 259:1742-1745.
16. Hunter, T., and M. Karin. 1992. The regulation of transcription by phosphorylation. Cell 70:375-387.
17. Igarashi, K.-I., G. Garotta, L. Ozmen, A. Ziemiecki, A. F. Wilks, H. G. Harpur, A. C. Larner, and D. S. Finbloom. 1994. Interferon-γ induces tyrosine phosphorylation of interferon-γ receptor and regulated association of protein tyrosine kinases Jak1 and Jak2 with its receptor. J. Biol. Chem. 269:14333-14336.
18. Ihle, J. N., B. A. Witthuhn, F. W. Quelle, K. Yamamoto, W. E. Thierfelder, B. Kreider, and S. Silvennoinen. 1994. Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends Biochem. Sci. 19:222-227.
19. Jiang, J., and M. Levine. 1993. Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen. Cell 72:741-752.
20. Lew, D. J., T. Decker, I. Strehlow, and J. E. Darnell, Jr. 1991. Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons. Mol. Cell Biol. 11:182-191.
21. Lütticken, C., P. Coffer, J. Yuan, C. Schwartz, C. Schindler, W. Kruijer, P. C. Heinrich, and F. Horn. 1995. Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction. FEBS Lett. 360:137-143.
22. Lütticken, C., U. M. Wegenka, J. Yuan, J. Buschmann, C. Schindler, A. Ziemiecki, A. G. Harpur, A. F. Wilks, K. Yasukawa, T. Taga, T. Kishimoto, G. Barbieri, S. Pellegrini, M. Sendtner, P. C. Heinrich, and F. Horn. 1994. Association of transcription factor APRF and the protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science 263:89-92.
23. Müller, M., J. Briscoe, C. Laxton, D. Guschin, A. Ziemiecki, O. Silvennoinen, A. G. Harpur, G. Barbieri, B. A. Witthuhn, C. Schindler, S. Pellegrini, A. Wilks, J. N. Ihle, G. R. Stark, and I. M. Kerr. 1993. The protein tyrosine kinase jak1 complements defects in interferon α/β and -γ signal transduction. Nature (London) 366:129-135.
24. Pearse, R. N., R. Feinman, K. Shuai, J. Darnell, and J. V. Ravetch. 1993. Interferon γ-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3. Proc. Natl. Acad. Sci. USA 90:4314-4318.
25. Pellegrini, S., and C. Schindler. 1993. Early events in signalling by interferons. Trends Biochem. Sci. 18:338-342.
26. Perez, C., J. Wietzerbin, and P. D. Benech. 1993. Two cis-DNA elements involved in myeloid-cell-specific expression and gamma interferon (IFN-γ) activation of the human high-affinity Fcγ receptor gene: a novel IFN regulatory mechanism. Mol. Cell. Biol. 13:2182-2192.
27. Rothman, P., B. Kreider, M. Azam, D. Levy, U. Wegenka, A. Eilers, T. Decker, F. Horn, H. Kashleva, J. Ihle, and C. Schindler. 1994. Cytokines signal through tyrosine phophorylation of a family of related transcription factors. Immunity 1:457-468.
28. Schindler, C., X.-Y. Fu, T. Improta, R. H. Aebersold, and J. E. Darnell, Jr. 1992. The proteins of ISGF-3: one gene encodes 91 and 84 kDa ISGF-3α proteins. Proc. Natl. Acad. Sci. USA 89:7836-7839.
29. Schindler, C., K. Shuai, V. R. Prezioso, and J. E. Darnell, Jr. 1992. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 257:809-813.
30. Shuai, K. 1994. Interferon-activated signal transduction to the nucleus. Curr. Opin. Cell Biol. 6:253-258.
31. Shuai, K., C. Horvath, L. H. Tsai-Huang, S. A. Qureshi, D. Cowburn, and J. E. Darnell, Jr. 1994. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76:821-828.
32. Shuai, K., C. Schindler, V. Prezioso, and J. E. Darnell. 1992. Activation of transcription by IFN-γ: Tyrosine phosphorylation of a 91-kD DNA-binding protein. Science 258:1808-1812.
33. Shuai, K., G. R. Stark, I. M. Kerr, and J. E. Darnell. 1993. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ Science 261:1744-1746.
34. Shuai, K., A. Ziemiecki, A. Wilks, A. G. Harpur, H. B. Sadowski, M. Z. Gilman, and J. E. Darnell. 1993. Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature (London) 366:580-583.
35. Silvennoinen, O., J. N. Ihle, J. Schlessinger, and D. E. Levy. 1993. Interferon-induced nuclear signalling by Jak protein tyrosine kinases. Nature (London) 366:583-585.
36. Strehlow, I., D. Seegert, C. Frick, F.-C. Bange, C. Schindler, E. C. Boettger, and T. Decker. 1993. The gene encoding IFP 53/tryptophanyl-tRNA synthetase is regulated by the gamma-interferon activation factor. J. Biol. Chem. 268:16590-16595.
37. Testa, U., R. Masciulli, E. Tritarelli, R. Pustorino, G. Mariani, R. Martucci, T. Barberi, A. Camagna, M. Valtieri, and C. Peschle. 1993. Effect of endogenous and exogenous interferons on the differentiation of human monocyte cell line U937. J. Immunol. 150:2418-2430.
38. Trinchieri, G., and B. Perussia. 1985. Immune interferon: a pleiotropic lymphokine with multiple effects. Immunol. Today 6:131-136.
39. Watling, D., D. Guschin, M. Müller, O. Silvennoinen, B. A. Witthuhn, F. W. Quelle, N. C. Rogers, C. Schindler, G. R. Stark, J. N. Ihle, and I. M. Kerr. 1993. Complementation by the protein tyrosine kinase jak2 of a mutant cell line defective in the interferon-γ signal transduction pathway. Nature (London) 366:166-170.
40. Wilks, A. F., A. Harpur, R. R. Kurban, S. J. Ralph, G. Zurcher, and A. Ziemiecki, 1991. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell. Biol. 11:2057-2065.
41. Wilson, K. C., and D. Finbloom. 1992. Interferon-γ rapidly induces in human monocytes a DNA-binding factor that recognizes the γ response region within the promoter of the gene for the high-affinity Fcγ receptor. Proc. Natl. Acad. Sci. USA 89:11964-11968.
42. Zhang, X., J. Blenis, H.-C. Li, C. Schindler, and S. Chen-Kiang. 1995. Requirement of serine phosphorylation for differential formation of Stat-promoter complexes in gp130 signaling. Science 267:1990-1994.