The anti‐emetic effects of CP‐99,994 in the ferret and the dog: role of the NK1 receptor

British Journal of Pharmacology

Volumn 115, Issue 1, 1995, Pages 84-94

  Watson, J W ^a   Gonsalves, S F ^a   Fossa, A A ^a   McLean, S ^a   Seeger, T ^a   Obach, S ^a   Andrews, P L R ^b  

^a PFIZER INC   (United States)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

area postrema; CP 99,994; emesis in dog; emesis in ferret; NK1 antagonist; nucleus tractus solitarius; Substance P; vagal stimulation

Indexed keywords

2 METHYLSEROTONIN; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; APOMORPHINE; CISPLATIN; COPPER SULFATE; IPECAC; LOPERAMIDE; NEUROKININ 1 RECEPTOR; OPIATE ANTAGONIST; SUBSTANCE P; TROPISETRON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIEMETIC ACTIVITY; ARTICLE; AUTORADIOGRAPHY; BLOOD PRESSURE; BRAIN STEM; BREATHING RATE; CARDIOVASCULAR RESPONSE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG BINDING; ELECTROSTIMULATION; FERRET; HEART RATE; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; SPLANCHNIC NERVE; SUBCUTANEOUS DRUG ADMINISTRATION; VAGUS NERVE STIMULATION; VOMITING;

ANIMAL; ANTIEMETICS; BRAIN STEM; DOGS; FERRETS; GAGGING; INDOLES; MALE; PIPERIDINES; RECEPTORS, NEUROKININ-1; SUBSTANCE P; VAGUS NERVE;

EID: 0029065938     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1995.tb16324.x     Document Type: Article

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