σ Ligands with Subnanomolar Affinity and Preference for the σ2 Binding Site. 1. 3-(ω-Aminoalkyl) - 1H-indoles

Journal of Medicinal Chemistry

Volumn 38, Issue 11, 1995, Pages 1998-2008

  Perregaard, Jens ^a   Moltzen, Ejner K ^a   Meier, Eddi ^a   Sánchez, Connie ^a  

^a H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 FLUOROPHENYL) 3 [4 [4 (4 FLUOROPHENYL) 1 PIPERIDINYL]BUTYL] 1H INDOLE; 1 CYCLOPROPYLMETHYL 4 [2 (4 FLUOROPHENYL) 2 OXOETHYL]PIPERIDINE; 1 PHENYLPIPERAZINE DERIVATIVE; 1' [4 [1 (4 FLUOROPHENYL) 1H INDOL 3 YL] 1 BUTYL]SPIRO[ISOBENZOFURAN 1(3H),4' PIPERIDINE]; 1,3 BIS(2 METHYLPHENYL)GUANIDINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 (OMEGA AMINOALKYL) 1H INDOLE DERIVATIVE; 4 PHENYLPIPERIDINE DERIVATIVE; ALPHA (4 FLUOROPHENYL) 4 (5 FLUORO 2 PYRIMIDINYL) 1 PIPERAZINEBUTANOL; ALPHA 1 ADRENERGIC RECEPTOR; DOPAMINE 2 RECEPTOR; HALOPERIDOL; INDOLE DERIVATIVE; KETANSERIN; L 687384; LIGAND; LU 28179; LU 29253; PENTAZOCINE; PRAZOSIN; RIMCAZOLE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR; SIGMA OPIATE RECEPTOR; SPIPERONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BRAIN LEVEL; DRUG PENETRATION; DRUG STRUCTURE; DRUG SYNTHESIS; EXPLORATORY BEHAVIOR; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; RECEPTOR BINDING; SUBCUTANEOUS DRUG ADMINISTRATION; TRANQUILIZING ACTIVITY;

ANIMAL; BINDING SITES; COMPARATIVE STUDY; INDOLES; LIGANDS; MALE; PIPERIDINES; RATS; RATS, WISTAR; RECEPTORS, SIGMA; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029065278     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00011a019     Document Type: Article

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