Structural evidence that the activation peptide is not released upon thrombin cleavage of factor XIII

Thrombosis Research

Volumn 78, Issue 5, 1995, Pages 389-397

  Yee, Vivien C ^a   Pedersen, Lars C ^a   Bishop, Paul D ^b   Stenkamp, Ronald E ^a   Teller, David C ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b ZYMOGENETICS INC   (United States)

Author keywords

activation peptide; factor XIII; X ray crystallography

Indexed keywords

BLOOD CLOTTING FACTOR 8; PEPTIDE; THROMBIN;

ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; HUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY;

ANIMAL; BINDING SITES; CATTLE; CRYSTALLOGRAPHY, X-RAY; ENZYME PRECURSORS; FACTOR XIII; HUMAN; MODELS, MOLECULAR; PEPTIDES; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THROMBIN;

EID: 0029064315     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/0049-3848(95)00072-Y     Document Type: Article

References (15)

1. Transglutaminases: multifunctional cross-linking enzymes that stabilize tissues
2. Contribution of fibrin stabilization to clot strength
3. Effects of crosslinking on the rigidity and proteolytic susceptibility of human fibrin clots
4. 2+-related regulatory function of fibrinogen
5. Factor XIII (fibrin-stabilizing factor)
6. Effect of temperature and pH on factor XIII from human placenta
7. Three-dimensional structure of a transglutaminase: human blood coagulation factor XIII
8. Transglutaminase factor XIII uses proteinase-like catalytic triad to crosslink macromolecules
9. Expression, purification, and characterization of human factor XIII in Saccharomyces cerevisiae
10. Crystallographic R factor refinement by molecular dynamics
11. Improved methods for building protein models in electron density maps and the location of errors in these models
12. Crystallization of blood coagulation factor XIII by an automated procedure
13. X-ray structure determination of factor XIII
14. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
15. Interactions of factor XIII with fibrin as substrate and cofactor