Treatment of ovariectomized rats with the complex of rhIGF-I/IGFBP-3 Increases cortical and cancellous bone mass and improves structure in the femoral neck

Calcified Tissue International

Volumn 57, Issue 1, 1995, Pages 40-46

  Bagi, C M ^a   DeLeon, E ^a   Brommage, R ^a   Rosen, D ^a   Sommer, A ^a  

^a Celtrix Pharmaceuticals   (United States)

Author keywords

Femoral neck; Histomorphometry; Ovariectomy; rhIGF I IGFBP 3

Indexed keywords

RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MASS; BONE REMODELING; BONE TURNOVER; CANCELLOUS BONE; CONTROLLED STUDY; CORTICAL BONE; FEMALE; FEMUR NECK; HIP FRACTURE; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOPENIA; OVARIECTOMY; PERIOSTEUM; PRIORITY JOURNAL; RAT;

ANIMAL; BONE DENSITY; BONE DEVELOPMENT; BONE DISEASES, METABOLIC; BONE REMODELING; CARRIER PROTEINS; FEMALE; FEMUR NECK; HIP FRACTURES; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH-FACTOR-BINDING PROTEINS; MALE; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS;

EID: 0029063402     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/BF00298995     Document Type: Article

References (26)

1. Hip fractures: a worldwide problem today and tomorrow
2. Bone mass measurement: prediction of risk
3. Cortical aging differences and fracture implications for the human femoral neck
4. Age-related structural changes in trabecular and cortical bone: cellular mechanisms and biomechanical consequences
5. Contribution of the trabecular component to mechanical strength and bone mineral content of the femoral neck
6. The mechanical characteristics of cancellous bone at the upper femoral region
7. Fracture risk: a role for compact bone
8. The ovariectomized rat model of postmenopausal bone loss
9. On the rat model of human osteopenias and osteoporoses
10. Decreased serum levels of insulin-like growth factors and IGF binding protein 3 in osteoporosis
11. Benefit of systemically administered rhIGF-I and rhIGF-I/IGFBP-3 on cancellous bone in ovariectomized rats
12. Changes in bone mineral and bone formation rates during pregnancy and lactation in rats
13. Bone histomorphometry: standardization of the nomenclature, symbols and units. Report of the ASBMR Histomorphometry Committee
14. Long-term osteopenic changes in cancellous bone structure in ovariectomized rats
15. Comparison of osteopenic changes in cancellous bone induced by ovariectomy and/or immobilization in adult rats
16. Calcium absorption and osseous organ- tissue- and envelope-specific changes following ovariectomy in rats
17. Comparative morphometric changes in rat cortical bone following ovariectomy and/or immobilization
18. Confirmation of the sex differences in continuing subperiosteal apposition
19. Sex differences in age-related remodeling of the femur and tibia
20. Changes in trabecular pattern of the upper end of the femur as an index of osteoporosis
21. Age and sex-related changes in the structure and strength of the human femoral shaft
22. Changes in bone mass and fracture type in patients with hip fractures
23. Effect of bone size, not density, on the stiffness of the proximal part of normal and osteoporotic human femora
24. The positive effect of parathyroid hormone on femoral neck bone strength in ovariectomized rats is more pronounced than that of estrogen or bisphosphonates
25. Exercise can provide protection against bone loss and prevent the decrease in mechanical strength of femoral neck in ovariectomized rats