메뉴 건너뛰기




Volumn 72, Issue 1, 1995, Pages 123-128

Mutations, expression and genomic instability of the H-ras proto-oncogene in squamous cell carcinomas of the head and neck

Author keywords

H ras expression; Oral cancer; Ras mutations; Squamous cell carcinoma of the head and neck

Indexed keywords

MESSENGER RNA;

EID: 0029060026     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.1995.287     Document Type: Article
Times cited : (92)

References (38)
  • 1
    • 0023226760 scopus 로고
    • The relation of ras oncogene product p21 expression to clinicopathological status criteria and clinical outcome in squamous cell head and neck cancer
    • AZUMA M, FURUMOTO N, KAWAMATA H, YOSHIDA H, YANAGAWA T, YURA Y, HAYASHI Y, TAKEGAWA Y, AND SATO M. (1987). The relation of ras oncogene product p21 expression to clinicopathological status criteria and clinical outcome in squamous cell head and neck cancer. Cancer J., 1, 375–380.
    • (1987) Cancer J , vol.1 , pp. 375-380
    • Azuma, M.1    Furumoto, N.2    Kawamata, H.3    Yoshida, H.4    Yanagawa, T.5    Yura, Y.6    Hayashi, Y.7    Takegawa, Y.8    Sato, M.9
  • 3
    • 0027732538 scopus 로고
    • Proteins regulating ras and its relatives
    • BOGUSKI MS, AND McCORMICK F. (1993). Proteins regulating Ras and its relatives. Nature, 366, 643 -654.
    • (1993) Nature , vol.366
    • Boguski, M.S.1    McCORMICK, F.2
  • 4
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • BOS JL. (1989). Ras oncogenes in human cancer: A review. Cancer Res., 49, 4682–4689.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 5
    • 0019363396 scopus 로고
    • Organization and expression of eukaryotic split genes coding for proteins
    • BREATHNACH R, AND CHAMBON P. (1981). Organization and expression of eukaryotic split genes coding for proteins. Annu. Rev. Biochem., 50, 349–383.
    • (1981) Annu. Rev. Biochem , vol.50 , pp. 349-383
    • Breathnach, R.1    Chambon, P.2
  • 8
    • 0028226102 scopus 로고
    • Overexpression of c-k-ras, c-n-ras and transforming growth factor 0 co-segregate with tumorigenicity in morphologically transformed c3h 10t1/2 cell lines
    • COLEMAN WB, THRONEBURG DB, GRISHAM JW, AND SMITH GJ. (1994). Overexpression of c-K-ras, c-N-ras and transforming growth factor 0 co-segregate with tumorigenicity in morphologically transformed C3H 10T1/2 cell lines. Carcinogenesis, 15, 1005–1012.
    • (1994) Carcinogenesis , vol.15 , pp. 1005-1012
    • Coleman, W.B.1    Throneburg, D.B.2    Grisham, J.W.3    Smith, G.J.4
  • 9
    • 0026636412 scopus 로고
    • Oncogenes and tumour-suppressor genes in squamous cell carcinoma of the head and neck
    • FIELD JK. (1992). Oncogenes and tumour-suppressor genes in squamous cell carcinoma of the head and neck. Eur. J. Cancer Oral Oncol., 28B, 67–76.
    • (1992) Eur. J. Cancer Oral Oncol , vol.28B , pp. 67-76
    • Field, J.K.1
  • 10
    • 0025253945 scopus 로고
    • The role of ras and myc oncogenes in human solid tumours and their relevance in diagnosis and prognosis. A revew
    • HELD JK, AND SPANDIDOS DA. (1990). The role of ras and myc oncogenes in human solid tumours and their relevance in diagnosis and prognosis. A revew. Anticancer Res., 10, 1–22.
    • (1990) Anticancer Res , vol.10 , pp. 1-22
    • Held, J.K.1    Spandidos, D.A.2
  • 11
    • 0022746134 scopus 로고
    • Clinical relevance of oncogene expression in head and neck tumours
    • FIELD JK, LAMOTHE A, AND SPANDIDOS DA. (1986). Clinical relevance of oncogene expression in head and neck tumours. Anticancer Res., 6, 595–600.
    • (1986) Anticancer Res , vol.6 , pp. 595-600
    • Field, J.K.1    Lamothe, A.2    Spandidos, D.A.3
  • 12
    • 0026600101 scopus 로고
    • Low leves of ras p21 oncogene expression correlates with clinical outcome in head and neck squamous cell carcinoma
    • HELD JK, YIAGNISIS M, SPANDIDOS DA, GOSNEY JR, PAPADIMITRIOU K, VAUGHAN ED, AND STELL PM. (1992). Low leves of ras p21 oncogene expression correlates with clinical outcome in head and neck squamous cell carcinoma. Eur. J. Surg. Oncol., 18, 168–176.
    • (1992) Eur. J. Surg. Oncol , vol.18 , pp. 168-176
    • Held, J.K.1    Yiagnisis, M.2    Spandidos, D.A.3    Papadimitriou, G.4    Vaughan, E.D.5    Stell, P.M.6
  • 13
    • 0027442865 scopus 로고
    • Quantitation of rna using the polymerase chain reaction
    • FOLEY KP, LEONARD MW, AND ENGEL JD. (1993). Quantitation of RNA using the polymerase chain reaction. Trends Genet., 9, 380–385.
    • (1993) Trends Genet , vol.9 , pp. 380-385
    • Foley, K.P.1    Leonard, M.W.2    Engel, J.D.3
  • 14
    • 0024368617 scopus 로고
    • Genetic alterations of c-myc, c-erbb-2, and c-ha-ras-1 protooncogenes and clinical associations in human breast carcinomas
    • GARCIA I, DIETRICH P-Y, AAPRO M, VAUTHIER G, VADAS L, AND ENGEL E. (1989). Genetic alterations of c-myc, c-erbB-2, and c-Ha-ras-1 protooncogenes and clinical associations in human breast carcinomas. Cancer Res., 49, 6675 -6679.
    • (1989) Cancer Res , vol.49
    • Garcia, I.1    Dietrich, P.-Y.2    Aapro, M.3    Vauthier, G.4    Vadas, L.5    Engel, E.6
  • 15
    • 0027170003 scopus 로고
    • Allelic variation of reporter gene activation by the hras1 minisatellite
    • GREEN M, AND KRONTIRIS TG. (1993). Allelic variation of reporter gene activation by the HRAS1 minisatellite. Genomics, 17, 429–434.
    • (1993) Genomics , vol.17 , pp. 429-434
    • Green, M.1    Krontiris, T.G.2
  • 16
    • 0025776167 scopus 로고
    • Low incidence of point mutation at codon 12 of k-ras proto-oncogene in squamous cell carcinoma of the upper aerodigestive tract
    • HIRANO T, STEELE PE, AND GULCKMAN JL. (1991). Low incidence of point mutation at codon 12 of K-ras proto-oncogene in squamous cell carcinoma of the upper aerodigestive tract. Ann. Otol. Rhinol. Laryngol., 100, 597–599.
    • (1991) Ann. Otol. Rhinol. Laryngol , vol.100 , pp. 597-599
    • Hirano, T.1    Steele, P.E.2    Gulckman, J.L.3
  • 17
    • 0023392401 scopus 로고
    • Identification of the principal promoter sequence of the c-h-ras transforming oncogene: Deletion analysis of the 5’-flanking region by focus formation assay
    • HONKAWA H, MASAHASHI W, HASHIMOTO S, AND HASHIMOTOGOTOH T. (1987). Identification of the principal promoter sequence of the c-H-ras transforming oncogene: Deletion analysis of the 5’-flanking region by focus formation assay. Mol. Cell Biol., 7, 2933–2940.
    • (1987) Mol. Cell Biol , vol.7 , pp. 2933-2940
    • Honkawa, H.1    Masahashi, W.2    Hashimoto, S.3    Hashimotogotoh, T.4
  • 18
    • 0023392401 scopus 로고
    • Identification of the principal promoter sequence of the c-h-ras transforming oncogene: Deletion analysis of the 5’-fianking region by focus formation assay
    • HONKAWA H, MASAHASHI W, HASHIMOTO S, AND HASHIMOTOGOTOH T. (1987). Identification of the principal promoter sequence of the c-H-ras transforming oncogene: Deletion analysis of the 5’-fianking region by focus formation assay. Mol. Cell Biol., 7, 2933–2940.
    • (1987) Mol. Cell Biol , vol.7 , pp. 2933-2940
    • Honkawa, H.1    Masahashi, W.2    Hashimoto, S.3    Hashimotogotoh, T.4
  • 19
    • 0024318896 scopus 로고
    • Loss of harvey ras heterozygosity in oral squamous carcinoma
    • HOWELL RE, WONG FS, AND FENWICK RG. (1989). Loss of Harvey ras heterozygosity in oral squamous carcinoma. J. Oral Pathol., 18, 79–83.
    • (1989) J. Oral Pathol , vol.18 , pp. 79-83
    • Howell, R.E.1    Wong, F.S.2    Fenwick, R.G.3
  • 20
    • 0028170396 scopus 로고
    • Loss of heterozygosity and microsatellite instability of the h-ras gene in cancer of the head and neck
    • KIARIS H, SPANDIDOS DA, JONES AS, AND FIELD JK. (1994). Loss of heterozygosity and microsatellite instability of the H-ras gene in cancer of the head and neck. Int. J. Oncol., 5, 579–582.
    • (1994) Int. J. Oncol , vol.5 , pp. 579-582
    • Kiaris, H.1    Spandidos, D.A.2    Jones, A.S.3    Field, J.K.4
  • 21
    • 0028170392 scopus 로고
    • A method to detect and quantitate the expression of normal versus mutant h-ras transcripts at codon 12
    • KOTSINAS A, KIARIS H, AND SPANDIDOS DA. (1994). A method to detect and quantitate the expression of normal versus mutant H-ras transcripts at codon 12. Int. J. Oncol., 5, 479–483.
    • (1994) Int. J. Oncol , vol.5 , pp. 479-483
    • Kotsinas, A.1    Kiaris, H.2    Spandidos, D.A.3
  • 22
    • 0027214689 scopus 로고
    • An association between the risk of cancer and mutations in the hras1 minisatellite locus
    • KRONTIRIS TG, DEVLIN B, KARP DD, ROBERT NJ, AND RISCH N. (1993). An association between the risk of cancer and mutations in the HRAS1 minisatellite locus. N. Engl. J. Med., 329, 517–523.
    • (1993) N. Engl. J. Med , vol.329 , pp. 517-523
    • Krontiris, T.G.1    Devlin, B.2    Karp, D.D.3    Robert, N.J.4    Risch, N.5
  • 23
    • 0028370026 scopus 로고
    • Mutations of ki-ras oncogene codon 12 in betel quid chewing-related human oral squamous cell carcinoma in taiwan
    • KUO MYP, JENG JH, CHIANG CP, AND HAHN U. (1994). Mutations of Ki-ras oncogene codon 12 in betel quid chewing-related human oral squamous cell carcinoma in Taiwan. J. Oral. Pathol. Med., 23, 70–74.
    • (1994) J. Oral. Pathol. Med , vol.23 , pp. 70-74
    • Kuo, M.1    Jeng, J.H.2    Chiang, C.P.3    Hahn, U.4
  • 24
    • 0025237434 scopus 로고
    • Low incidence of ras-oncogene activation in human squamous cell carcinomas
    • RUMSBY G, CARTER RL, AND GUSTERSON BA. (1990). Low incidence of ras-oncogene activation in human squamous cell carcinomas. Br. J. Cancer, 61, 365 -368.
    • (1990) Br. J. Cancer , vol.61
    • Rumsby, G.1    Carter, R.L.2    Gusterson, B.A.3
  • 25
  • 27
    • 0025063619 scopus 로고
    • Analysis of the c-ha-ras-1 gene for deletion, mutation, amplification and expression in lymph node metastases of human head and neck carcinomas
    • SHENG ZM, BARROIS M, KLIJANIENKO J, MICHEAU C, RICHARD JM, AND RIOU G. (1990). Analysis of the c-Ha-ras-1 gene for deletion, mutation, amplification and expression in lymph node metastases of human head and neck carcinomas. Br. J. Cancer, 62, 398 -404.
    • (1990) Br. J. Cancer , vol.62
    • Sheng, Z.M.1    Barrois, M.2    Klijanienko, J.3    Micheau, C.4    Richard, J.M.5    Riou, G.6
  • 29
    • 0025520003 scopus 로고
    • Expression of the normal h-ras 1 gene can suppress the transformed and tumorigenic phenotypes induced by mutant ras genes
    • SPANDIDOS DA, FRAME M, AND WILKIE NM. (1990). Expression of the normal H-ras 1 gene can suppress the transformed and tumorigenic phenotypes induced by mutant ras genes. Anticancer Res., 10, 1543–1554.
    • (1990) Anticancer Res , vol.10 , pp. 1543-1554
    • Spandidos, D.A.1    Wilkie, F.2
  • 30
    • 0023237498 scopus 로고
    • Transcriptional enhancer activity in the variable tandem repeat dna sequence downstream of the human ha-ras-1 gene
    • SPANDIDOS DA, AND HOLMES L. (1987). Transcriptional enhancer activity in the variable tandem repeat DNA sequence downstream of the human Ha-ras-1 gene. FEBS Lett., 218, 41–46.
    • (1987) FEBS Lett , vol.218 , pp. 41-46
    • Spandidos, D.A.1    Holmes, L.2
  • 31
    • 0021203313 scopus 로고
    • Malignant transformation of early passage rodent cells by a single mutated human oncogene
    • SPANDIDOS DA, AND WILKIE NM. (1984). Malignant transformation of early passage rodent cells by a single mutated human oncogene. Nature, 310, 469–475.
    • (1984) Nature , vol.310 , pp. 469-475
    • Spandidos, D.A.1    Wilkie, N.M.2
  • 32
    • 0022038637 scopus 로고
    • Multiple transcriptional activation of cellular oncogenes in human head and neck solid tumours
    • SPANDIDOS DA, LAMOTHE A, AND FIELD JK. (1985). Multiple transcriptional activation of cellular oncogenes in human head and neck solid tumours. Anticancer Res., 5, 221–224.
    • (1985) Anticancer Res , vol.5 , pp. 221-224
    • Spandidos, D.A.1    Lamothe, A.2    Field, J.K.3
  • 33
    • 0024956799 scopus 로고
    • The immunohistochemical detection of ras p21 and its correlation with differentiation in oral cancers
    • TSUJI T, SASAKI K, HIRAOKA F, AND SHINOZAKI F. (1989). The immunohistochemical detection of ras p21 and its correlation with differentiation in oral cancers. J. Tumour Marker Oncol., 4, 415–419.
    • (1989) J. Tumour Marker Oncol , vol.4 , pp. 415-419
    • Tsuji, T.1    Sasaki, K.2    Hiraoka, F.3    Shinozaki, F.4
  • 35
    • 0028299985 scopus 로고
    • Hypomethylation of ccgg sites in the 3’-region of h-ras protooncogene is frequent and is associated with h-ras allele loss in non-small cell lung cancer
    • VACHTENHEIM J, HORAKOVA I, AND NOVOTNA H. (1994). Hypomethylation of CCGG sites in the 3’-region of H-ras protooncogene is frequent and is associated with H-ras allele loss in non-small cell lung cancer. Cancer Res., 54, 1145–1148.
    • (1994) Cancer Res , vol.54 , pp. 1145-1148
    • Vachtenheim, J.1    Horakova, I.2    Novotna, H.3
  • 37
    • 0026719081 scopus 로고
    • Point mutations in the ha-ras oncogene are detectable in formalin-fixed tissues of oral squamous cell carcinomas, but are infrequent in british cases
    • WARNAKULSURIYA KAAS, CHANG SE, AND JOHNSON NW. (1992). Point mutations in the Ha-ras oncogene are detectable in formalin-fixed tissues of oral squamous cell carcinomas, but are infrequent in British cases. J. Oral. Pathol. Med., 21, 225–229.
    • (1992) J. Oral. Pathol. Med , vol.21 , pp. 225-229
    • Warnakulsuriya, K.1    Chang, S.E.2    Johnson, N.W.3
  • 38
    • 0027474504 scopus 로고
    • Ras gene point mutation is a rare event in premalignant tissues and malignant cells and tissues from oral mucosal lesions
    • YEUDALL WA, TORRANCE LK, ELSEGOOD KA, SPEIGHT P, SCULLY C, AND PRIME SS. (1993). ras Gene point mutation is a rare event in premalignant tissues and malignant cells and tissues from oral mucosal lesions. Eur. J. Cancer Oral Oncol., 29B, 63–67.
    • (1993) Eur. J. Cancer Oral Oncol , vol.29B , pp. 63-67
    • Yeudall, W.A.1    Torrance, L.K.2    Elsegood, K.A.3    Speight, P.4    Scully, C.5    Prime, S.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.