The contribution of acidosis to renal osteodystrophy

Kidney International

Volumn 47, Issue 6, 1995, Pages 1816-1832

  Bushinsky, David A ^a  

^a STRONG MEMORIAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDOSIS; CASE REPORT; HUMAN; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; RENAL OSTEODYSTROPHY; REVIEW; SECONDARY HYPERPARATHYROIDISM;

EID: 0029059351     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1995.251     Document Type: Article

References (170)

1. BUSHINSKY DA, KRIEGER NS: Role of the skeleton in calcium homeostasis, in The Kidney: Physiology and Pathophysiology, edited by SELDIN DW, GIEBISH G, New York, Raven, 1992, pp 2395-2430
2. BUSHINSKY DA, KRIEGER NS: Integration of calcium metabolism in the adult, in Disorders of Bone and Mineral Metabolism, edited by COE FL, FAVUS MJ, New York, Raven, 1992, pp 417-432
3. BUSHINSKY DA: Internal exchanges of hydrogen ions: Bone, in The Regulation of Acid-Base Balance, edited by SELDIN DW, GIEBISH G, New York, Raven, 1989, pp 69-88
4. NEUMAN WF, NEUMAN MW: The Chemical Dynamics of Bone Mineral, Chicago, University of Chicago Press, 1958
5. TRIFFITT JT, TEREPKA AR, NEUMAN WF: A comparative study of the exchange in vivo of major constituents of bone mineral. Calcif Tissue Res 2:165-176, 1968
6. POSNER AS: Bone mineral and the mineralization process, in Bone and Mineral Research, edited by PECK WA, Amsterdam, Elsevier, 1987, pp 65-99
7. POSNER AS: The structure of bone apatite surfaces. J Biomed Mater Res 19:241-250, 1985
8. POSNER AS: The mineral of bone. Clin Orthop Rel Res 200:87-99, 1985
9. 2-titration curves in acute hypercapnia obtained with a modified titration technique. J Appl Physiol 48:197-201, 1980
10. WIDDOWSON EM, MCCANCE RA, SPRAY CM: The chemical composition of the human body. Clin Sci 10:113-125, 1951
11. WIDDOWSON EM, DICKERSON JWT: Chemical composition of the body, in Mineral Metabolism, edited by COMAR CL, BRONNER F, New York, Academic Press, 1964, pp 1-247
12. MCSHEEHY PMJ, CHAMBERS TJ: Osteoblastic cells mediate osteoclastic responsiveness to PTH. Endocrinology 118:824-828, 1986
13. 3 stimulates rat osteoblastic cells to release a soluble factor that increases osteoclastic bone resorption. J Clin Invest 80:425-429, 1987
14. BARON R, NEFF L, LOUVARD D, COURTOY PJ: Cell-mediated extracellular acidification and bone resorption: Evidence for a low pH in resorbing lacunae and localization of a 100 Kd lysosomal membrane protein at the osteoclast ruffled border. J Cell Biol 101:2210-2222, 1985
15. VAES G: Cellular biology and biochemical mechanism of bone resorption. A review of recent developments on the formation, activation, and mode of action of osteoclasts. Clin Orthop Rel Res 231:239-271, 1988
16. BLAIR HC, TEITELBAUM SL, GHISELLI R, GLUCK S: Osteoclastic bone resorption by a polarized vacuolar proton pump. Science 245:855-857, 1989
17. TETI A, BLAIR HC, TEITELBAUM SL, KAHN AJ, KOZIOL C, KONSEK J, ZAMBONIN-ZALLONE A, SCHLESINGER PH: Cytoplasmic pH regulation and chloride/bicarbonate exchange in avian osteoclasts. J Clin Invest 83:227-233, 1989
18. BUSHINSKY DA: Calcium and phosphorus homeostasis, in Nephrology Primer, edited by GREENBERG A, Academic Press, New York, 1994, pp 406-413
19. GOODMAN WG, COBURN JW, RAMIREZ JA, SLATOPOLSKY E, SALUSKY IB: Renal osteodystrophy in adults and children, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, edited by FAVUS MJ, Raven, New York, 1993, pp 304-323
20. COBURN JW, SLATOPOLSKY E: Vitamin D, parathyroid hormone, and the renal osteodystrophies, in The Kidney, edited by BRENNER B, RECTOR FC, Philadelphia, Saunders, 1991, pp 2036-2120
21. SHERRARD DJ, OTT SM, MALONEY NA, ANDRESS DL, COBURN JW: Uremic osteodystrophy: classification, cause and treatment, in Clinical Disorders of Bone and Mineral Metabolism, edited by FRAME B, POTTS J, Amsterdam, Excerpta Medica, 1984, pp 254-259
22. PITTS TO, PIRAINO BH, MITRO R, CHEN TC, SEGRE GV, GREENBERG A, PUSHCETT JB: Hyperparathyroidism and 1,25-dihydroxyvitamin D deficiency in mild, moderate and severe renal failure. J Clin Endocrinol Metab 67:876-881, 1988
23. DELMEZ JA, SLATOPOLSKY E: Hyperphosphatemia: its consequences and treatment in patients with chronic renal disease. Am J Kidney Dis 19:303-317, 1992
24. SLATOPOLSKY E, CAGLAR S, PENNELL JP, TAGGART DD, CANTERBURY JM, REISS E, BRICKER NS: On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog. J Clin Invest 50:492-499, 1971
25. 3. Physiol Rev 64:478-504, 1984
26. NEMERE I, NORMAN AW: Transport of calcium, in Handbook of Physiology, edited by FIELD M, FRIZZEL RA, Bethesda, American Physiological Society, 1991, pp 337-360
27. 3 is correlated to receptor occupancy. J Biol Chem 261:16943-16947, 1986
28. REISS E, CANTERBURY JM, BERCOVITZ MA, KAPLAN EL: The role of phosphate in the secretion of parathyroid hormone in man. J Clin Invest 49:2146-2149, 1970
29. RUSSELL J, LETTIERI D, SHERWOOD LM: Direct regulation by calcium of cytoplasmic messenger RNA coding for pre-proparathyroid hormone in isolated bovine parathyroid cells. J din Invest 72:1851-1855, 1983
30. 3 receptors in parathyroid glands. J Biol Chem 253:1065-1073, 1978
31. 3 in chick parathyroid glands. Biochem Biophys Res Commun 62:781-788, 1975
32. 3 in chick parathyroid glands. Proc Natl Acad Sci 72:4871-4875, 1975
33. SILVER J, RUSSELL J, SHERWOOD LM: Regulation by vitamin D metabolites of messenger ribonucleic acid for pre-proparathyroid hormone in isolated bovine parathyroid cells. Proc Natl Acad Sci 82:4270-4273, 1985
34. 3 of transcription of the pre-parathyroid hormone gene. Endocrinology 119:2864-2866, 1986
35. 3 suppresses parathyroid hormone secretion from bovine parathyroid cells in tissue culture. Endocrinology 117:2114-2119, 1985
36. CHAN YL, MCKAY C, DYE E, SLATOPOLSKY E: The effect of 1,25-dihydroxycholecalciferol on parathyroid hormone secretion by monolayer cultures of bovine parathyroid cells. Calcif Tissue Int 38:27-32, 1986
37. OLDHAM SB, SMITH R, HARTENBOWER DL, HENRY HL, NORMAN AW, COBURN JW: The acute effects of 1,25-dihydroxycholecalciferol on serum immunoreactive parathyroid hormone in the dog. Endocrinology 104:248-254, 1979
38. CHERTOW BS, BAYLINK DJ, WERGEDAL JE, SU MHH, NORMAN AW: Decrease in serum immunoreactive parathyroid hormone in rats and in parathyroid hormone secretion in vitro by 1,25-dihydroxycholecalciferol. J Clin Invest 56:668-678, 1975
39. 3 in the parathyroid glands of patients with renal failure. N Engl J Med 316:1573-1577, 1987
40. SLATOPOLSKY E, WEERTS C, THIELAN J, HORST R, HARTER H, MARTIN KJ: Marked suppression of secondary hyperparathyroidism by intravenous administration of 1,25-dihydroxycholecalciferol in uremic patients. J Clin Invest 74:2136-2143, 1984
41. ANDRESS DL, NORRIS KC, COBURN JW, SLATOPOLSKY EA, SHERRARD DJ: Intravenous calcitriol in the treatment of refractory osteitis fibrosa of chronic renal failure. N Engl J Med 321:274-279, 1989
42. BROWN AJ, RITTER CR, FINCH JL, MORRISSEY J, MARTIN KJ, MURAYAMA E, NISHII Y, SLATOPOLSKY E: The noncalcemic analogue of vitamin D, 22-oxocalcitriol, suppresses parathyroid hormone synthesis and secretion. J Clin Invest 84:728-732, 1989
43. MACDONALD PN, RITTER C, BROWN AJ, SLATOPOLSKY E: Retinoic acid suppresses parathyroid hormone (PTH) secretion and preproPTH mRNA levels in bovine parathyroid cell culture. J Clin Invest 93:725-730, 1994
44. MARTIN KJ, HRUSKA KA, FREITAG JJ, KLAHR S, SLATOPOLSKY E: The peripheral metabolism of parathyroid hormone. N Engl J Med 301:1092-1098, 1979
45. MARTIN K, HRUSKA K, GREENWALT A, KLAHR S, SLATOPOLSKY E: Selective uptake of intact parathyroid hormone by the liver; differences between hepatic and renal uptake. J Clin Invest 58:781-788, 1976
46. MARTIN KJ, HRUSKA KA, LEWIS J, ANDERSON C, SLATOPOLSKY E: The renal handling of parathyroid hormone: role of peritubular uptake and glomerular filtration. J Clin Invest 60:808-814, 1977
47. GOLTZMAN D, HENDERSON B, LOVERIDGE N: Cytochemical bioassay of parathyroid hormone: characteristics of the assay and analysis of circulating hormonal forms. J Clin Invest 65:1309-1317, 1980
48. ALFREY AC, LEGENDRE GR, KAEHNY WD: The dialysis encephalopathy syndrome: possible aluminum intoxication. N Engl J Med 294:184-188, 1976
49. PLATTS MM, GOODE GC, HISLOP JS: Composition of the domestic water supply and the incidence of fractures and encephalopathy in patients on home dialysis. Br Med J 2:657-660, 1977
50. OTT SM, MALONEY NA, COBURN JW, ALFREY AC, SHERRARD DJ: The prevalence of bone aluminum deposition in renal osteodystrophy and its relation to the response to calcitriol therapy. N Engl J Med 307:709-713, 1982
51. HODSMAN AB, SHERRARD DJ, ALFREY AC, OTT S, BRICKMAN AS, MILLER NL, MALONEY NA, COBURN JW: Bone aluminum and histomorphometric features of renal osteodystrophy. J Clin Endocrinol Metab 54:539-546, 1982
52. PIERIDES AM, EDWARDS WG JR, CULLU US JR, MCCALL JT, ELLIS HA: Hemodialysis encephalopathy with osteomalacic fractures and muscle weakness. Kidney Int 18:115-124, 1980
53. MALONEY NA, OTT SM, ALFREY AC, MILLER NL, COBURN JW, SHERRARD DJ: Histological quantitation of aluminum in iliac bone from patients with renal failure. J Lab Clin Med 99:206-216, 1982
54. GOODMAN WG, HENRY DA, HORST R, NUDELMAN RK, ALFREY AC, COBURN JW: Parenteral aluminum administration in the dog: II. Induction of osteomalacia and effect of vitamin D metabolism. Kidney Int 25:370-375, 1984
55. GOODMAN WG, GILLIGAN J, HORST R: Short-term aluminum administration in the rat. Effects on bone formation and relationship to renal osteomalacia. J Clin Invest 73:171-181, 1984
56. SPRAGUE SM, KRIEGER NS, BUSHINSKY DA: Aluminum inhibits bone nodule formation and calcification in vitro. Am J Physiol (Renal Fluid Electrolyte Physiol 33) 264:F882-F890, 1993
57. SPRAGUE SM, BUSHINSKY DA: Mechanism of aluminum-induced calcium efflux from cultured neonatal mouse calvariae. Am J Physiol (Renal Fluid Electrolyte Physiol 27) 258:F583-F588, 1990
58. HERCZ G, PEI Y, GREENWOOD A, MANUEL A, SAIPHOO C, GOODMAN WG, SEGRE GV, FENTON S, SHERRARD DJ: Aplastic osteodystrophy without aluminum: The role of "suppressed" parathyroid function. Kidney Int 44:860-866, 1993
59. SALUSKY IB, COBURN JW, BRILL J, et al: Bone disease in pediatric patients undergoing dialysis with CAPD or CCPD. Kidney Int 33:975-982, 1988
60. BUSHINSKY DA: Metabolic Acidosis, in The Principles of Nephrology, edited by JACOBSON HR, STRIKER GE, KLAHR S, St. Louis, Mosby, 1995, pp 924-932
61. SCHWARTZ WB, RELMAN AS: Acidosis in renal disease. N Engl J Med 256:1184-1186, 1957
62. LEMANN J JR, LITZOW JR, LENNON EJ: Studies of the mechanism by which chronic metabolic acidosis augments urinary calcium excretion in man. J Clin Invest 46:1318-1328, 1967
63. LEMANN J JR, LITZOW JR, LENNON EJ: The effects of chronic acid loads in normal man: Further evidence for the participation of bone mineral in the defense against chronic metabolic acidosis. J Clin Invest 45:1608-1614, 1966
64. LENNON EJ, LEMANN J JR, LITZOW JR: The effects of diet and stool composition on the net external acid balance of normal subjects. J Clin Invest 45:1601-1607, 1966
65. BUSHINSKY DA, ORI Y: Effects of metabolic and respiratory acidosis on bone. Curr Opin Nephrol Hypertens 2:588-596, 1993
66. GENNARI FJ: Nephrology Forum: Acid-base balance in dialysis patients. Kidney Int 28:678-688, 1985
67. OTTE KE, LILLEVANG ST, RASMUSSEN AG, CHRISTENSEN HK, PEDERSEN FB: Acetate or bicarbonate for haemodialysis: a randomised, double-blind controlled trial. Nephrol Dial Transplant 5:931-936, 1990
68. GOTCH FA, SARGENT JA, KEEN ML: Hydrogen ion balance in dialysis therapy. Artif Organs 6:388-395, 1982
69. LEFEBVRE A, DE VERNEJOUL MC, GUERIS J, GOLDFARB B, GRAULET AM, MORIEUX C: Optimal correction of acidosis changes progression of dialysis osteodystrophy. Kidney Int 36:1112-1118, 1989
70. SCHOENFELD P: Care of the patient between dialyses, in Introduction to Dialysis, edited by COGAN MG, SCHOENFELD P, New York, Churchill Livingstone, 1991, pp 241-328
71. MAN NK, FOURNIER G, THIREAU P, GAILLARD JL, FUNCK-BRENTANO J: Effect of bicarbonate-containing dialysate on chronic hemodialysis patients: a comparative study. Artif Organs 6:421-425, 1982
72. 2 in chronic metabolic acidosis. Kidney Int 22:311-314, 1982
73. KRAUT JA, MISHLER DR, KUROKAWA K: Effect of colchicine and calcitonin on calcemic response to metabolic acidosis. Kidney Int 25:608-612, 1984
74. BUSHINSKY DA, KRIEGER NS, GEISSER DI, GROSSMAN EB, COE FL: Effects of pH on bone calcium and proton fluxes in vitro. Am J Physiol (Renal Fluid Electrolyte Physiol 14) 245:F204-F209, 1983
75. BUSHINSKY DA, GOLDRING JM, COE FL: Cellular contribution to pH mediated calcium flux in neonatal mouse calvariae. Am J Physiol (Renal Fluid Electrolyte Physiol 17) 248:F785-F789, 1985
76. BUSHINSKY DA, SESSLER NE, GLENA RE, FEATHERSTONE JDB: Proton-induced physicochemical calcium release from ceramic apatite disks. J Bone Miner Res 9:213-220, 1994
77. BUSHINSKY DA, LECHLEIDER RJ: Mechanism of proton-induced bone calcium release: calcium carbonate dissolution. Am J Physiol (Renal Fluid Electrolyte Physiol 22) 253:F998-F1005, 1987
78. BOSKEY AL, POSNER AS: Bone structure, composition, and mineralization. Orthop Clin North Am 15:597-612, 1984
79. GRYNPAS MD, BONAR LC, GLIMCHER MJ: Failure to detect an amorphous calcium-phosphate solid phase in bone mineral. A radial distribution function study. Calcif Tissue Int 36:291-301, 1984
80. NELSON DGA, FEATHERSTONE JDB: The preparation, analysis and characterization of carbonated apatites. Calcif Tissue Int 34:S69-S81, 1982
81. BUSHINSKY DA, SESSLER NE: Critical role of bicarbonate in calcium release from bone. Am J Physiol (Renal Fluid Electrolyte Physiol 32) 263:F510-F515, 1992
82. SWAN RC, PITTS RF: Neutralization of infused acid by nephrectomized dogs. J Clin Invest 34:205-212, 1955
83. BUSHINSKY DA, LEVI-SETTI R, COE FL: Ion microprobe determination of bone surface elements: Effects of reduced medium pH. Am J Physiol (Renal Fluid Electrolyte Physiol 19) 250:F1090-F1097, 1986
84. BUSHINSKY DA, WOLBACH W, SESSLER NE, MOGILEVSKY R, LEVISETTI R: Physicochemical effects of acidosis on bone calcium flux and surface ion composition. J Bone Min Res 8:93-102, 1993
85. BERGSTROM WH, RUVA FD: Changes in bone sodium during acute acidosis in the rat. Am J Physiol 198:1126-1128, 1960
86. BETTICE JA, GAMBLE JL JR: Skeletal buffering of acute metabolic acidosis. Am J Physiol 229:1618-1624, 1975
87. BETTICE JA: Skeletal carbon dioxide stores during metabolic acidosis. Am J Physiol (Renal Fluid Electrolyte Physiol 16) 247:F326-F330, 1984
88. BUSHINSKY DA, LAM BC, NESPECA R, SESSLER NE, GRYNPAS MD: Decreased bone carbonate content in response to metabolic, but not respiratory, acidosis. Am J Physiol (Renal Fluid Electrolyte Physiol 34) 265:F530-F536, 1993
89. BUSHINSKY DA: Net proton influx into bone during metabolic, but not respiratory, acidosis. Am J Physiol (Renal Fluid Electrolyte Physiol 23) 254:F306-F310, 1988
90. BUSHINSKY DA: Effects of parathyroid hormone on net proton flux from neonatal mouse calvariae. Am J Physiol (Renal Fluid Electrolyte Physiol 21) 252:F585-F589, 1987
91. CHABALA JM, LEVI-SETTI R, BUSHINSKY DA: Alteration in surface ion composition of cultured bone during metabolic, but not respiratory, acidosis. Am J Physiol (Renal Fluid Electrolyte Physiol 30) 261:F76-F84, 1991
92. 3. Am J Physiol (Endocrinol Metab Physiol 20) 257:E815-E822, 1989
93. BUSHINSKY DA, CHABALA J, LEVI-SETTI R: Ion microprobe analysis of mouse calvariae in vitro: evidence for a "bone membrane." Am J Physiol (Endocrinol Metab 19) 256:E152-E158, 1989
94. 44Ca labeling of bone by scanning ion microprobe. Am J Physiol (Endocrinol Metab 22) 259:E586-E592, 1990
95. WACHMAN A, BERNSTEIN DS: Parathyroid hormone in metabolic acidosis: its role in pH homeostasis. Clin Orthop Rel Res 69:252-263, 1970
96. MADIAS NE, JOHNS CA, HOMER SM: Independence of the acute acid-buffering response from endogenous parathyroid hormone. Am J Physiol (Renal Fluid Electrolyte Physiol 12) 243:F141-F149, 1982
97. BARON R: Molecular mechanisms of bone resorption by the osteoclast. Anal Rec 224:317-324, 1989
98. ANDERSON RE, WOODBURY DM, JEE WS: Humoral and ionic regulation of osteoclast acidity. Calcif Tissue Int 39:252-258, 1986
99. GREEN J, KLEEMAN CR: Role of bone in regulation of systemic acid-base balance. Kidney Int 39:9-26, 1991
100. OH MS: Irrelevance of bone buffering to acid-base homeostasis in chronic metabolic acidosis. Nephron 59:7-10, 1991
101. LEMANN J JR, ADAMS ND, GRAY RW: Urinary calcium excretion in human beings. N Engl J Med 301:535-541, 1979
102. LITZOW JR, LEMANN J JR, LENNON EJ: The effect of treatment of acidosis on calcium balance in patients with chronic azotemic renal disease. J din Invest 46:280-286, 1967
103. KRAUT JA, MISHLER DR, SINGER FR, GOODMAN WG: The effects of metabolic acidosis on bone formation and bone resorption in the rat. Kidney Int 30:694-700, 1986
104. ARNETT TR, DEMPSTER DW: Effect of pH on bone resorption by rat osteoclasts in vitro. Endocrinology 119:119-124, 1986
105. + stimulation of cell-mediated bone resorption in tissue culture. Am J Physiol (Endocrinol Metab 16) 253:E90-E98, 1987
106. BUSHINSKY DA: Net calcium efflux from live bone during chronic metabolic, but not respiratory acidosis. Am J Physiol (Renal Fluid Electrolyte Physiol 25) 256:F836-F842, 1989
107. KRIEGER NS, SESSLER NE, BUSHINSKY DA: Acidosis inhibits osteoblastic and stimulates osteoclastic activity in vitro. Am J Physiol (Renal Fluid Electrolyte Physiol 31) 262:F442-F448, 1992
108. SPRAGUE SM, KRIEGER NS, BUSHINSKY DA: Greater inhibition of in vitro bone mineralization with metabolic than respiratory acidosis. Kidney Int 46:1199-1206, 1994
109. BUSHINSKY DA, NILSSON EL: Acidosis and PTH have additive effects on osteoclastic bone resorption (abstract). J Am Soc Nephrol 5:848, 1994
110. BECK N, WEBSTER SK: Effects of acute metabolic acidosis on parathyroid hormone action and calcium mobilization. Am J Physiol 230:127-131, 1976
111. SCHWARTZ WB, HALL PW III, HAYS RM, RELMAN AS: On the mechanism of acidosis in chronic renal disease. J Clin Invest 38:39-52, 1959
112. GOODMAN AD, LEMANN J JR, LENNON EJ, RELMAN AS: Production, excretion, and net balance of fixed acid in patients with renal acidosis. J Clin Invest 44:495-506, 1965
113. PELLEGRINO ED, BLITZ RM: The composition of human bone in uremia. Observations on the reservoir functions of bone and demonstration of a labile fraction of bone carbonate. Medicine 44:397-418, 1965
114. BARZEL US: The effect of excessive acid feeding on bone. Calcif Tissue Res 4:94-100, 1969
115. BURNELL JM: Changes in bone sodium and carbonate in metabolic acidosis and alkalosis in the dog. J Clin Invest 50:327-331, 1971
116. CHAN Y-L, SAVDIE E, MASON RS, POSEN S: The effect of metabolic acidosis on vitamin D metabolites and bone histology in uremic rats. Calcif Tissue Int 37:158-164, 1985
117. BUSHINSKY DA, SESSLER NE, KRIEGER NS: Greater unidirectional calcium efflux from bone during metabolic, than respiratory, acidosis. Am J Physiol (Renal Fluid Electrolyte Physiol. 31) 262: F425-F431, 1992
118. ARNETT TR, DEMPSTER DW: A comparative study of disaggregated chick and rat osteoclasts in vitro: effects of calcitonin and prostaglandins. Endocrinology 120:602-608, 1987
119. BUSHINSKY DA: Stimulated osteoclastic and suppressed osteoblastic activity in metabolic but not respiratory acidosis. Am J Physiol (Cell Physiol) 268:C80-C88, 1995
120. MANSOOR GA, BUSHINSKY DA: Influence of the accompanying anion on proton-mediated calcium efflux from bone (abstract). J Am Soc Nephrol 4:699, 1993
121. MOORE EW: Ionized calcium in normal serum, ultrafiltrates and whole blood determined by ion-exchange electrodes. J Clin Invest 49:318-334, 1970
122. KAPLAN EL, HILL BJ, LOCKE S, TOTH DN, PESKIN GW: Metabolic acidosis and parathyroid hormone secretion in sheep. J Lab Clin Med 78:819-822, 1971
123. 2-vitamin D. Calcif Tissue Int 28:233-238, 1979
124. WEBER HP, GRAY RW, DOMINGUEZ JH, LEMANN J JR: The lack of effect of chronic metabolic acidosis on 25-OH vitamin D metabolism and serum parathyroid hormone in humans. J Clin Endocrinol Metab 43:1047-1055, 1976
125. COE FL, FIRPOE JJ JR, HOLLANDSWORTH DL, SEGIL L, CANTERBURY JM, REISS E: Effect of acute and chronic metabolic acidosis on serum immunoreactive parathyroid hormone in man. Kidney Int 8:262-273, 1975
126. 3 response to low calcium diet. Am J Physiol (Renal Fluid Electrolyte Physiol 12) 243:F570-F575, 1982
127. 3 synthesis by rat proximal tubules. J Lab Clin Med 106:286-292, 1985
128. 3 independently of PTH and phosphorus in the rat. J Clin Invest 76:1599-1604, 1985
129. 3 by calcium in the parathyroidectomized parathyroid hormone replete rat. J Bone Miner Res 4:929-935, 1989
130. 3 to variation of ionized calcium during chronic acidosis. Am J Physiol (Renal Fluid Electrolyte Physiol 18) 249:F361-365, 1985
131. LEE SW, RUSSELL J, AVIOLI LV: 25-Hydroxycholecalciferol to 1,25-dihydroxycholecalciferol: conversion impaired by systemic metabolic acidosis. Science 195:994-996, 1977
132. 3 1-hydroxylase by chronic metabolic acidosis. Am J Physiol 243:E265-E271, 1982
133. COE FL, BUSHINSKY DA: The pathophysiology of hypercalciuria. Am J Physiol (Renal Fluid Electrolyte Physiol 16) 247:F1-F13, 1984
134. 3 response to phosphorus restriction. Am J Physiol (Renal fluid Electrolyte Physiol 25) 256:F285-F289, 1989
135. KRAUT JA, GORDON EM, RANSOM JC, HORST R, SLATOPOLSKY E, COBURN JW, KUROKAWA K: Effect of chronic metabolic acidosis on vitamin D metabolism in humans. Kidney Int 24:644-648, 1983
136. SEBASTIAN A, HARRIS ST, OTTAWAY JH, TODD KM, MORRIS RC JR: Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. N Engl J Med 330:1776-1781, 1994
137. KRAUT JA, COBURN JW: Bone, acid, and osteoporosis. N Engl J Med 330:1821-1822, 1994
138. MCSHERRY E, MORRIS RC: Attainment and maintenance of normal stature with alkali therapy in infants and children with classic renal tubular acidosis. J Clin Invest 61:509-527, 1978
139. MCSHERRY E: Acidosis and growth in nonuremic renal disease. Kidney Int 14:349-354, 1978
140. CHALLA A, KRIEG RJ JR, THABET MA, VELDHUIS JD, CHAN JC: Metabolic acidosis inhibits growth hormone secretion in rats: mechanism of growth retardation. Am J Physiol 265:E547-E553, 1993
141. BRENNER RJ, SPRING DB, SEBASTIAN A, et al: Incidence of radiographically evident bone disease, nephrocalcinosis, and nephrolithiasis in various types of renal tubular acidosis. N Engl J Med 307:217-221, 1982
142. MOKA PALMA FJ, ELLIS HA, COOK DB, DEWAR JH, WARD MK, WILKINSON R, KERR DNS: Osteomalacia in patients with chronic renal failure before dialysis or transplantation. Q J Med (New Series) 52:332-348, 1983
143. WEST CD, SMITH WC: An attempt to elucidate the cause of growth retardation in renal disease. Am J Dis Child 91:460-476, 1956
144. PELLEGRINO ED, BLITZ RM, LETTERI JM: Inter-relationships of carbonate, phosphate, monohydrogen phosphate, calcium, magnesium, and sodium in uraemic bone: Comparison of dialyzed and non-dialyzed patients. Clin Sci Mol Med 53:307-316, 1977
145. KAYE M, FRUETH AJ, SILVERMAN M: A study of vertebral bone powder from patients with chronic renal failure. J Clin Invest 49:442-453, 1970
146. BISHOP MC, LEDINGHAM JG: Alkali treatment of renal osteodystrophy. Br Med J 4:529, 1972
147. COCHRAN M, WILKINSON R: Effect of correction of metabolic acidosis on bone mineralization rates in patients with renal osteomalacia. Nephron 15:98-110, 1975
148. STANBURY SW: Bone disease in uremia. Am J Med 44:714-724, 1968
149. DENT CE, HARPER CM, PHILPOT GR: The treatment of renal-glomerular osteodystrophy. Q J Med 30:1-31, 1961
150. FLETCHER RF, JONES JH, MORGAN DB: Bone disease in chronic renal failure. Q J Med 32:321-339, 1963
151. CLARKSON EM, MCDONALD SJ, DE WARDENER HE: The effect of high intake of calcium carbonate in normal subjects and patients with chronic renal failure. Clin Sci 30:425-438, 1966
152. MAKOFF DL, GORDON A, FRANKLIN SS, GERSTEIN AR, MAXWELL MH: Chronic calcium carbonate therapy in uremia. Arch Intern Med 123:15-21, 1969
153. SLATOPOLSKY E, WEERTS C, LOPEZ-HILKER S, NORWOOD K, ZINK M, WINDOS D, DELMEZ J: Calcium carbonate as a phosphate binder in patients with chronic renal failure undergoing dialysis. N Engl J Med 315:157-161, 1986
154. HERCZ G, KRAUT JA, ANDRESS DA, HOWARD N, ROBERTS C, SHERRARD DJ, ET AL: Use of calcium carbonate as a phosphate binder in dialysis patients. Miner Electrolyte Metab 12:314-319, 1986
155. KAYE M: Long-term studies using a calcium-free dialysate. Clin Nephrol 40:221-224, 1993
156. EVANSON JM: The response to the infusion of parathyroid extract in hypocalcemic states. Clin Sci 31:63-75, 1966
157. LLACH F, MASSRY SG, SINGER FR, KUROKAWA K, KAYE JH, COBURN JW: Skeletal resistance of endogenous parathyroid hormone in patients with early renal failure. A possible cause for secondary hyperparathyroidism. J Clin Endocrinol Metab 41:339-345, 1975
158. RAISZ LG, NIEMANN I: Effect of phosphate calcium and magnesium on bone resorption and hormonal response in tissue culture. Endocrinology 85:446-452, 1969
159. LLACH F, MASSRY SG, KOFFLER A, MALLUCHE HH, SINGER FR, BRICKMAN AS, KUROKAWA K: Secondary hyperparathyroidism in early renal failure: Role of phosphate retention. Kidney Int 12:459-463, 1977
160. KAPLAN MA, CANTERBURY JM, GAVELLAS G, JAFFE D, BOURGOIGNIE JJ, REISS E, BRICKER NS: The calcemic and phosphaturic effects of parathyroid hormone in the normal and uremic dog. Metabolism 27:1785-1792, 1978
161. GALCERAN T, MARTIN KJ, MORRISSEY JJ, SLATOPOLSKY E: Role of 1,25-dihydroxyvitamin D on the skeletal resistance to parathyroid hormone. Kidney Int 32:801-807, 1987
162. SILVER IA, MURRILLS RJ, ETHERINGTON DJ: Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts. Exp Cell Res 175:266-276, 1988
163. TETI A, BLAIR HC, SCHLESINGER P, GRANO M, ZAMBONIN-ZALLONE A, KAHN AJ, TEITELBAUM SL, HRUSHKA KA: Extracellular protons acidify osteoclasts, reduce cytosolic calcium, and promote expression of cell-matrix attachment structures. J Clin Invest 84:773-780, 1989
164. HALL TJ, CHAMBERS TJ: Optimal bone resorption by isolated rat osteoclasts requires chloride/bicarbonate exchange. Calcif Tissue Int 45:378-380, 1989
165. SLY WS, WHYTE MP, SUNDARAM V, TASHIAN RE, HEWETT-EMMETT D, GUIBAUD P, VAINSEL M, BALUARTE HJ, GRUSKIN A, AL-MOSAWI M, SAKATI N, OHLSSON A: Carbonic anhydrase II deficiency in 12 families with the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification. N Engl J Med 313:139-145, 1985
166. SLY WS, HEWETT-EMMETT D, WHYTE MP, YU YS, TASHIAN RE: Carbonic anhydrase II deficiency identified as the primary defect in the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification. Proc Nat Acad Sci 80:2752-2756, 1983
167. WAITE LC, VOLKERT WA, KENNY AD: Inhibition of bone resorption by acetazolamide in the rat. Endocrinology 87:1129-1139, 1970
168. MINKIN C, JENNINGS JM: Carbonic anhydrase and bone remodeling: sulfonamide inhibition of bone resorption in organ culture. Science 176:1031-1033, 1971
169. BASTANI B, GLUCK S, HILDEN S, JOHNS C, YANG L, MADIAS N: Adaptation of renal vacuolar H-ATPase to acute or chronic respiratory acidosis in the rat (abstract). J Am Soc Nephrol 4:831, 1993
170. ADROGUÉ HJ, MADIAS NE: Changes in plasma potassium concentration during acute acid-base disturbances. Am J Med 71:456-467, 1981