메뉴 건너뛰기




Volumn 69, Issue 7, 1995, Pages 4127-4136

Hepatitis C virus-encoded NS2-3 protease: Cleavage-site mutagenesis and requirements for bimolecular cleavage

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; SERINE PROTEINASE; VIRUS ENZYME;

EID: 0029059334     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.69.7.4127-4136.1995     Document Type: Article
Times cited : (83)

References (56)
  • 1
    • 0027285404 scopus 로고
    • Dengue 2 virus NS2B and NS3 form a stable complex that can cleave NS3 within the helicase domain
    • Arias, C. F., F. Preugschat, and J. H. Strauss. 1993. Dengue 2 virus NS2B and NS3 form a stable complex that can cleave NS3 within the helicase domain. Virology 193:888-899.
    • (1993) Virology , vol.193 , pp. 888-899
    • Arias, C.F.1    Preugschat, F.2    Strauss, J.H.3
  • 2
    • 0027287798 scopus 로고
    • Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions
    • Bartenschlager, R., L. Ahlborn-Laake, J. Mous, and H. Jacobsen. 1993. Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J. Virol. 67:3835-3844.
    • (1993) J. Virol. , vol.67 , pp. 3835-3844
    • Bartenschlager, R.1    Ahlborn-Laake, L.2    Mous, J.3    Jacobsen, H.4
  • 3
    • 0028241489 scopus 로고
    • Kinetic and structural analyses of hepatitis C virus polyprotein processing
    • Bartenschlager, R., L. Ahlborn-Laake, J. Mous, and H. Jacobsen. 1994. Kinetic and structural analyses of hepatitis C virus polyprotein processing. J. Virol. 68:5045-5055.
    • (1994) J. Virol. , vol.68 , pp. 5045-5055
    • Bartenschlager, R.1    Ahlborn-Laake, L.2    Mous, J.3    Jacobsen, H.4
  • 4
    • 0026039916 scopus 로고
    • Processing of the yellow fever virus nonstructural polyprotein: A catalytically active NS3 proteinase domain and NS2B are required for cleavages at dibasic sites
    • Chambers, T. J., A. Grakoui, and C. M. Rice. 1991. Processing of the yellow fever virus nonstructural polyprotein: a catalytically active NS3 proteinase domain and NS2B are required for cleavages at dibasic sites. J. Virol. 65: 6042-6050.
    • (1991) J. Virol. , vol.65 , pp. 6042-6050
    • Chambers, T.J.1    Grakoui, A.2    Rice, C.M.3
  • 5
  • 6
    • 0027486484 scopus 로고
    • Mutagenesis of the yellow fever virus NS2B protein: Effects on proteolytic processing, NS2B-NS3 complex formation, and viral replication
    • Chambers, T. J., A. Nestorowicz, S. M. Amberg, and C. M. Rice. 1993. Mutagenesis of the yellow fever virus NS2B protein: effects on proteolytic processing, NS2B-NS3 complex formation, and viral replication. J. Virol. 67:6797-6807.
    • (1993) J. Virol. , vol.67 , pp. 6797-6807
    • Chambers, T.J.1    Nestorowicz, A.2    Amberg, S.M.3    Rice, C.M.4
  • 7
    • 0025201350 scopus 로고
    • Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein
    • Chambers, T. J., R. C. Weir, A. Grakoui, D. W. McCourt, J. F. Bazan, R. J. Fletterick, and C. M. Rice. 1990. Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein. Proc. Natl. Acad. Sci. USA 87:8898-8902.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 8898-8902
    • Chambers, T.J.1    Weir, R.C.2    Grakoui, A.3    McCourt, D.W.4    Bazan, J.F.5    Fletterick, R.J.6    Rice, C.M.7
  • 8
    • 0025286510 scopus 로고
    • The coding region for the 54-kDa protein of several pestiviruses lacks host insertions but reveals a "zinc finger-like" domain
    • De Moerlooze, L., M. Desport, A. Renard, C. Lecomte, J. Brownlie, and J. A. Martial. 1990. The coding region for the 54-kDa protein of several pestiviruses lacks host insertions but reveals a "zinc finger-like" domain. Virology 177:812-815.
    • (1990) Virology , vol.177 , pp. 812-815
    • De Moerlooze, L.1    Desport, M.2    Renard, A.3    Lecomte, C.4    Brownlie, J.5    Martial, J.A.6
  • 10
    • 0024538318 scopus 로고
    • Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones
    • Erdös, E. G., and R. A. Skidgel. 1989. Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones. FASEB J. 3:145-151.
    • (1989) FASEB J. , vol.3 , pp. 145-151
    • Erdös, E.G.1    Skidgel, R.A.2
  • 11
    • 0022340978 scopus 로고
    • Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product
    • Evan, G. I., G. K. Lewis, G. Ramsay, and J. M. Bishop. 1985. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol. 5:3610-3616.
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 3610-3616
    • Evan, G.I.1    Lewis, G.K.2    Ramsay, G.3    Bishop, J.M.4
  • 12
    • 0028290579 scopus 로고
    • Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins
    • Failla, C., L. Tomei, and R. De Francesco. 1994. Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins. J. Virol. 68:3753-3760.
    • (1994) J. Virol. , vol.68 , pp. 3753-3760
    • Failla, C.1    Tomei, L.2    De Francesco, R.3
  • 13
    • 0027499688 scopus 로고
    • Deletion analysis of Dengue virus type 4 nonstructural protein NS2B: Identification of a domain required for NS2B-NS3 proteinase activity
    • Falgout, B., R. H. Miller, and C.-J. Lai. 1993. Deletion analysis of Dengue virus type 4 nonstructural protein NS2B: identification of a domain required for NS2B-NS3 proteinase activity. J. Virol. 67:2034-2042.
    • (1993) J. Virol. , vol.67 , pp. 2034-2042
    • Falgout, B.1    Miller, R.H.2    Lai, C.-J.3
  • 14
    • 0025864149 scopus 로고
    • Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of Dengue virus nonstructural proteins
    • Falgout, B., M. Pethel, Y.-M. Zhang, and C.-J. Lai. 1991. Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of Dengue virus nonstructural proteins. J. Virol. 65:2467-2475.
    • (1991) J. Virol. , vol.65 , pp. 2467-2475
    • Falgout, B.1    Pethel, M.2    Zhang, Y.-M.3    Lai, C.-J.4
  • 15
    • 0000357440 scopus 로고
    • Classification and nomenclature of viruses: Fifth report of the international committee on taxonomy of viruses
    • Francki, R. I. B., C. M. Fauquet, D. L. Knudson, and F. Brown. 1991. Classification and nomenclature of viruses: fifth report of the international committee on taxonomy of viruses. Arch. Virol. Suppl. 2:223.
    • (1991) Arch. Virol. Suppl. , vol.2 , pp. 223
    • Francki, R.I.B.1    Fauquet, C.M.2    Knudson, D.L.3    Brown, F.4
  • 16
    • 0000233999 scopus 로고
    • Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase
    • Fuerst, T. R., E. G. Niles, F. W. Studier, and B. Moss. 1986. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 83:8122-8126.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 8122-8126
    • Fuerst, T.R.1    Niles, E.G.2    Studier, F.W.3    Moss, B.4
  • 17
    • 0024344173 scopus 로고
    • Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes
    • Gorbalenya, A. E., E. V. Koonin, A. P. Donchenko, and V. M. Blinov. 1989. Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucleic Acids Res. 17:4713-4729.
    • (1989) Nucleic Acids Res. , vol.17 , pp. 4713-4729
    • Gorbalenya, A.E.1    Koonin, E.V.2    Donchenko, A.P.3    Blinov, V.M.4
  • 18
    • 0027414062 scopus 로고
    • Characterization of the hepatitis C virus-encoded serine proteinase: Determination of proteinase-dependent polyprotein cleavage sites
    • Grakoui, A., D. W. McCourt, C. Wychowski, S. M. Feinstone, and C. M. Rice. 1993. Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites. J. Virol. 67:2832-2843.
    • (1993) J. Virol. , vol.67 , pp. 2832-2843
    • Grakoui, A.1    McCourt, D.W.2    Wychowski, C.3    Feinstone, S.M.4    Rice, C.M.5
  • 20
    • 0027476809 scopus 로고
    • Expression and identification of hepatitis C virus polyprotein cleavage products
    • Crakoui, A., C. Wycbowski, C. Lin, S. M. Feinstone, and C. M. Rice. 1993. Expression and identification of hepatitis C virus polyprotein cleavage products. J. Virol. 67:1385-1395.
    • (1993) J. Virol. , vol.67 , pp. 1385-1395
    • Crakoui, A.1    Wycbowski, C.2    Lin, C.3    Feinstone, S.M.4    Rice, C.M.5
  • 21
    • 0025991559 scopus 로고
    • Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis
    • Hijikata, M., N. Kato, Y. Ootsuyama, M. Nakagawa, and K. Shimotohno. 1991. Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc. Natl. Acad. Sci. USA 88:5547-5551.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5547-5551
    • Hijikata, M.1    Kato, N.2    Ootsuyama, Y.3    Nakagawa, M.4    Shimotohno, K.5
  • 22
    • 0027163740 scopus 로고
    • Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus
    • Hijikata, M., H. Mizushima, T. Akagi, S. Mori, N. Kakiuchi, N. Kato, T. Tanaka, K. Kimura, and K. Shimotohno. 1993. Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J. Virol. 67:4665-4675.
    • (1993) J. Virol. , vol.67 , pp. 4665-4675
    • Hijikata, M.1    Mizushima, H.2    Akagi, T.3    Mori, S.4    Kakiuchi, N.5    Kato, N.6    Tanaka, T.7    Kimura, K.8    Shimotohno, K.9
  • 25
    • 0025787597 scopus 로고
    • Genomic structure of the human prototype strain H of hepatitis C virus: Comparison with American and Japanese isolates
    • Inchauspe, G., S. Zebedee, D.-H. Lee, M. Sugitani, M. Nasoff, and A. M. Prince. 1991. Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates. Proc. Natl. Acad. Sci. USA 88:10292-10296.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 10292-10296
    • Inchauspe, G.1    Zebedee, S.2    Lee, D.-H.3    Sugitani, M.4    Nasoff, M.5    Prince, A.M.6
  • 27
    • 2642699794 scopus 로고
    • Rapid and efficient site-specific mutagenesis without phenotypic selection
    • Kunkel, T. A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488-492.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 488-492
    • Kunkel, T.A.1
  • 28
    • 0028290389 scopus 로고
    • Processing of the hepatitis C virus E2-NS2 region: Identification of p7 and two distinct E2-specific products with different C termini
    • Lin, C., B. D. Lindenbach, B. Prágai, D. W. McCourt, and C. M. Rice. 1994. Processing of the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini. J. Virol. 68:5063-5073.
    • (1994) J. Virol. , vol.68 , pp. 5063-5073
    • Lin, C.1    Lindenbach, B.D.2    Prágai, B.3    McCourt, D.W.4    Rice, C.M.5
  • 29
    • 0028089739 scopus 로고
    • The hepatitis C virus NS3 serine proteinase: Trans processing requirements and cleavage kinetics
    • Lin, C., B. Prágai, A. Grakoui, J. Xu, and C. M. Rice. 1994. The hepatitis C virus NS3 serine proteinase: trans processing requirements and cleavage kinetics. J. Virol. 68:8147-8157.
    • (1994) J. Virol. , vol.68 , pp. 8147-8157
    • Lin, C.1    Prágai, B.2    Grakoui, A.3    Xu, J.4    Rice, C.M.5
  • 30
    • 85086350886 scopus 로고    scopus 로고
    • The hepatitis C virus NS3 serine proteinase and NS4A cofactor: Establishment of a cell-free trans-processing assay
    • in press
    • Lin, C., and C. M. Rice. The hepatitis C virus NS3 serine proteinase and NS4A cofactor: establishment of a cell-free trans-processing assay. Proc. Natl. Acad. Sci., in press.
    • Proc. Natl. Acad. Sci.
    • Lin, C.1    Rice, C.M.2
  • 31
    • 0029074519 scopus 로고
    • A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro
    • Lin, C., J. A. Thomson, and C. M. Rice. 1995. A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro. J. Virol. 69:4373-4380.
    • (1995) J. Virol. , vol.69 , pp. 4373-4380
    • Lin, C.1    Thomson, J.A.2    Rice, C.M.3
  • 35
    • 0028265186 scopus 로고
    • Analysis of N-terminal processing of hepatitis C virus nonstructural protein 2
    • Mizushima, H., M. Hijikata, Y. Tanji, K. Kimura, and K. Shimotohno. 1994. Analysis of N-terminal processing of hepatitis C virus nonstructural protein 2. J. Virol. 68:2731-2734.
    • (1994) J. Virol. , vol.68 , pp. 2731-2734
    • Mizushima, H.1    Hijikata, M.2    Tanji, Y.3    Kimura, K.4    Shimotohno, K.5
  • 36
    • 0016376184 scopus 로고
    • Comparative specificity of microbial proteinases
    • Morihara, K. 1974. Comparative specificity of microbial proteinases. Adv. Enzymol. Relat. Areas Mol. Biol. 41:179-243.
    • (1974) Adv. Enzymol. Relat. Areas Mol. Biol. , vol.41 , pp. 179-243
    • Morihara, K.1
  • 38
    • 0028274107 scopus 로고
    • The entire nucleotide sequence and classification of a hepatitis C virus isolate of a novel genotype from an Indonesian patient with chronic liver disease
    • Okamoto, H., M. Kojima, M. Sakamoto, H. Iizuka, S. Hadiwandowo, S. Suwignyo, Y. Miyakawa, and M. Mayumi. 1994. The entire nucleotide sequence and classification of a hepatitis C virus isolate of a novel genotype from an Indonesian patient with chronic liver disease. J. Gen. Virol. 75:629-635.
    • (1994) J. Gen. Virol. , vol.75 , pp. 629-635
    • Okamoto, H.1    Kojima, M.2    Sakamoto, M.3    Iizuka, H.4    Hadiwandowo, S.5    Suwignyo, S.6    Miyakawa, Y.7    Mayumi, M.8
  • 39
    • 0026751054 scopus 로고
    • Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: Comparative study of four distinct genotypes
    • Okamoto, H., K. Kurai, S.-I. Okada, K. Yamamoto, H. Iizuka, T. Tanaka, S. Fukuda, F. Tsuda, and S. Mishiro. 1992. Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: Comparative study of four distinct genotypes. Virology 188:331-341.
    • (1992) Virology , vol.188 , pp. 331-341
    • Okamoto, H.1    Kurai, K.2    Okada, S.-I.3    Yamamoto, K.4    Iizuka, H.5    Tanaka, T.6    Fukuda, S.7    Tsuda, F.8    Mishiro, S.9
  • 40
    • 0025933437 scopus 로고
    • Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: Comparison with reported isolates for conserved and divergent regions
    • Okamoto, H., S. Okada, Y. Sugiyama, K. Kurai, H. Iizuka, A. Machida, Y. Miyakawa, and M. Mayumi. 1991. Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions. J. Gen. Virol. 72: 2697-2704.
    • (1991) J. Gen. Virol. , vol.72 , pp. 2697-2704
    • Okamoto, H.1    Okada, S.2    Sugiyama, Y.3    Kurai, K.4    Iizuka, H.5    Machida, A.6    Miyakawa, Y.7    Mayumi, M.8
  • 41
    • 0024406166 scopus 로고
    • Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides including enkephalin-containing peptides
    • Orlowski, M., S. Reznik, J. Ayala, and A. R. Pierotti. 1989. Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides including enkephalin-containing peptides. Biochem. J. 261:951-958.
    • (1989) Biochem. J. , vol.261 , pp. 951-958
    • Orlowski, M.1    Reznik, S.2    Ayala, J.3    Pierotti, A.R.4
  • 42
    • 0025033393 scopus 로고
    • In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3
    • Preugschat, F., C.-W. Yao, and J. H. Strauss. 1990. In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3. J. Virol. 64:4364-4374.
    • (1990) J. Virol. , vol.64 , pp. 4364-4374
    • Preugschat, F.1    Yao, C.-W.2    Strauss, J.H.3
  • 43
    • 0020085011 scopus 로고
    • Association of Sindbis virion glycoproteins and their precursors
    • Rice, C. M., and J. H. Strauss. 1982. Association of Sindbis virion glycoproteins and their precursors. J. Mol. Biol. 154:325-348.
    • (1982) J. Mol. Biol. , vol.154 , pp. 325-348
    • Rice, C.M.1    Strauss, J.H.2
  • 44
    • 0028216599 scopus 로고
    • Entire nucleotide sequence and characterization of a hepatitis C virus of genotype V/3a
    • Sakamoto, M., Y. Akahane, F. Tsuda, T. Tanaka, D. G. Woodfield, and H. Okamoto. 1994. Entire nucleotide sequence and characterization of a hepatitis C virus of genotype V/3a. J. Gen. Virol. 75:1761-1768.
    • (1994) J. Gen. Virol. , vol.75 , pp. 1761-1768
    • Sakamoto, M.1    Akahane, Y.2    Tsuda, F.3    Tanaka, T.4    Woodfield, D.G.5    Okamoto, H.6
  • 45
    • 0023472472 scopus 로고
    • Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range of 1 to 100 kDa
    • Schägger, H., and G. von Jagow. 1987. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range of 1 to 100 kDa. Anal. Biochem. 166:368-379.
    • (1987) Anal. Biochem. , vol.166 , pp. 368-379
    • Schägger, H.1    Von Jagow, G.2
  • 46
    • 0014211618 scopus 로고
    • On the size of the active site in proteases. I. Papain
    • Schechter, I., and A. Berger. 1967. On the size of the active site in proteases. I. Papain. Biochem. Biophys. Res. Commun. 27:157-162.
    • (1967) Biochem. Biophys. Res. Commun. , vol.27 , pp. 157-162
    • Schechter, I.1    Berger, A.2
  • 47
    • 0028040540 scopus 로고
    • Complex processing and protein:protein interactions in the E2:NS2 region of HCV
    • Selby, M. J., E. Glazer, F. Masiarz, and M. Houghton. 1994. Complex processing and protein:protein interactions in the E2:NS2 region of HCV. Virology 204:114-122.
    • (1994) Virology , vol.204 , pp. 114-122
    • Selby, M.J.1    Glazer, E.2    Masiarz, F.3    Houghton, M.4
  • 49
    • 0028218513 scopus 로고
    • Identification of genotypes of hepatitis C virus by sequence comparisons in the core, E1 and NS5 regions
    • Simmonds, P., D. B. Smith, F. McOmish, P. L. Yap, J. Kolberg, M. S. Urdea, and E. C. Holmes. 1994. Identification of genotypes of hepatitis C virus by sequence comparisons in the core, E1 and NS5 regions. J. Gen. Virol. 75:1053-1061.
    • (1994) J. Gen. Virol. , vol.75 , pp. 1053-1061
    • Simmonds, P.1    Smith, D.B.2    McOmish, F.3    Yap, P.L.4    Kolberg, J.5    Urdea, M.S.6    Holmes, E.C.7
  • 50
    • 0027199917 scopus 로고
    • Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes
    • Suzich, J. A., J. K. Tamura, F. Palmer-Hill, P. Warrener, A. Grakoui, C. M. Rice, S. M. Feinstone, and M. S. Collett. 1993. Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes. J. Virol. 67:6152-6158.
    • (1993) J. Virol. , vol.67 , pp. 6152-6158
    • Suzich, J.A.1    Tamura, J.K.2    Palmer-Hill, F.3    Warrener, P.4    Grakoui, A.5    Rice, C.M.6    Feinstone, S.M.7    Collett, M.S.8
  • 52
    • 85086350115 scopus 로고    scopus 로고
    • Pestivirus
    • B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), in press. Raven Press, New York
    • Thiel, H.-J., P. G. W. Plagemann, and V. Moennig. Pestivirus. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Virology, 3rd ed., in press. Raven Press, New York.
    • Virology, 3rd Ed.
    • Thiel, H.-J.1    Plagemann, P.G.W.2    Moennig, V.3
  • 53
    • 0027176287 scopus 로고
    • NS3 is a serine protease required for processing of hepatitis C virus polyprotein
    • Tomei, L., C. Failla, E. Santolini, R. deFrancesco, and N. LaMonica. 1993. NS3 is a serine protease required for processing of hepatitis C virus polyprotein. J. Virol. 67:4017-4026.
    • (1993) J. Virol. , vol.67 , pp. 4017-4026
    • Tomei, L.1    Failla, C.2    Santolini, E.3    DeFrancesco, R.4    LaMonica, N.5
  • 54
    • 0025356409 scopus 로고
    • Description of a procedure which allows isolation of viral nonstructural proteins from BHK vertebrate cells infected with the West Nile flavivirus in a state which allows their direct chemical characterization
    • Wengler, G., G. Wengler, T. Nowak, and E. Castle. 1990. Description of a procedure which allows isolation of viral nonstructural proteins from BHK vertebrate cells infected with the West Nile flavivirus in a state which allows their direct chemical characterization. Virology 177:795-801.
    • (1990) Virology , vol.177 , pp. 795-801
    • Wengler, G.1    Wengler, G.2    Nowak, T.3    Castle, E.4
  • 55
    • 0025785808 scopus 로고
    • Pestivirus gene expression: Protein p80 of bovine viral diarrhea virus is a proteinase involved in polyprotein processing
    • Wiskerchen, M., and M. S. Collett. 1991. Pestivirus gene expression: protein p80 of bovine viral diarrhea virus is a proteinase involved in polyprotein processing. Virology 184:341-350.
    • (1991) Virology , vol.184 , pp. 341-350
    • Wiskerchen, M.1    Collett, M.S.2
  • 56
    • 0026471347 scopus 로고
    • Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5
    • Zhang, L., P. M. Mohan, and Padmanabhan. 1992. Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5. J. Virol. 66:7549-7554.
    • (1992) J. Virol. , vol.66 , pp. 7549-7554
    • Zhang, L.1    Mohan, P.M.2    Padmanabhan3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.