Ceramide inhibits pancreatic β-cell insulin production and mitogenesis and mimics the actions of interleukin-1β

FEBS Letters

Volumn 367, Issue 3, 1995, Pages 283-286

  Sjöholm, Åke ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Ceramide; IL 1 ; Insulin secretion; Islet; Sphingolipid

Indexed keywords

CERAMIDE; CERAMIDE DERIVATIVE; RECOMBINANT INTERLEUKIN 1BETA; SPHINGOMYELIN PHOSPHODIESTERASE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FETUS; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

ANIMAL; CELL DIVISION; CERAMIDES; GROWTH INHIBITORS; IN VITRO; INSULIN; INTERLEUKIN-1; ISLETS OF LANGERHANS; RATS; RATS, WISTAR; SECOND MESSENGER SYSTEMS; SPHINGOMYELIN PHOSPHODIESTERASE; SUPPORT, NON-U.S. GOV'T; TISSUE CULTURE;

EID: 0029059122     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(95)00470-T     Document Type: Article

References (32)

1. Role of polyamines in mitogenic and secretory responses of pancreatic beta-cells to growth factors.
2. TGF-beta stimulates insulin secretion and blocks mitogenic response of pancreatic beta-cells to glucose.
3. Differential effects of cytokines on long-term mitogenic and secretory responses of fetal rat pancreatic beta-cells.
4. Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells.