Localization of a gene for partial epilepsy to chromosome 10q

Nature Genetics

Volumn 10, Issue 1, 1995, Pages 56-60

  Ottman, Ruth ^a   Schiaffino, M Vittoria ^b   Renieri, Alessandra ^a   Nigris, Filomena De ^b   Galli, Lucia ^a   Bruttini, Mirella ^a   Gebbia, Marinella ^b   Bergen, Arthur A B ^c   Lewis, Richard A ^d   Ballabio, Andrea ^a,b  

^a Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^b TELETHON INSTITUTE OF GENETICS AND MEDICINE TIGEM   (Italy)

^c NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 10Q; FOCAL EPILEPSY; GENE LOCATION; GENE LOCUS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; PENETRANCE; POINT MUTATION; PRIORITY JOURNAL; SEIZURE;

ADOLESCENT; ADULT; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 10; EPILEPSIES, PARTIAL; FEMALE; GENETIC MARKERS; GENOTYPE; HUMAN; LINKAGE (GENETICS); MALE; MIDDLE AGE; PEDIGREE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0029059069     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng0595-56     Document Type: Article

References (25)

1. Hauser, W. A., Annegers, J. F. & Kurland, L. T. Prevalence of epilepsy in Rochester, Minnesota, 1940-1980. Epilepsia 31, 429-445 (1991).
2. Hauser, W. A., Annegers, J. F. & Kurland, L. T. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 34, 453-468 (1993).
3. Leppert, M. et al. Benign familial neonatal convulsions linked to genetic markers on chromosome 20. Nature 337, 647-648 (1989).
4. Lewis, T. B., Leach, R. J., Ward, K., O’Connell, P. & Ryan, S. G. Genetic heterogeneity in benign familial neonatal convulsions: identification of a new locus on chromosome 8q. Am. J. hum. Genet. 53, 670-675 (1993).
5. Steinlein, O. et al. Refinement of the localization of the gene for neuronal nicotinic acetylcholine receptor 4 subunit (CHRNA4) to human chromosome 20q13. 2-q13. 3. Genomics 22, 493-495 (1994).
6. Lehesjoki, A.-E. et al. Localization of a gene for progressive myoclonus epilepsy to chromosome 21q22. Proc. natn. Acad. Sci. U. S. A. 88, 3696-3699 (1991).
7. Greenberg, D. A. et al. Juvenile myoclonic epilepsy may be linked to the BF and HLA loci on human chromosome 6. Am. J. Med. Genet. 31, 185-192 (1988).
8. Weissbecker, K. A., Durner, M., Janz, D., Scaramelli, A., Sparkes, R. S. & Spence, M. A. Confirmation of linkage between juvenile myoclonic epilepsy locus and the HLA region of chromosome 6. Am. J. Med. Genet. 38, 32-86 (1991).
9. Durner, M., Sander, T., Greenberg, D. A., Johnson, K., Beck-Mannagetta, G. & Janz, D. Localization of idiopathic generalized epilepsy on chromosome 6p in families ascertained through juvenile myoclonic epilepsy patients. Neurology 41, 1651-1655 (1991).
10. Whitehouse, W. P. et al. Linkage analysis of idiopathic generalized epilepsy (IGE) and marker loci on chromosome 6p in families of patients with juvenile myoclonic epilepsy: no evidence for an epilepsy locus in the HLA region. Am. J. hum. Genet. 53, 652-662 (1993).
11. Commission on Classification and Terminololgy of the International League Against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 22, 489-501 (1981).
12. Commission on Classification and Terminology of the International League Against Epilepsy. A revised proposal for the classification of epilepsy and epileptic syndromes. Epilepsia 30, 268-278 (1989).
13. Ottman, R. Genetics of the partial epilepsies: a review. Epilepsia 30, 107-111 (1989).
14. Ottman, R., Annegers, J. F., Hauser, W. A. & Kurland, L. T. Seizure risk in offspring of parents with generalized vs. partial epilepsy. Epilepsia 30, 157-161 (1989).
15. Heijbel, J., Blom, S. & Rasmuson, M. Benign epilepsy of childhood with centrotemporal EEG foci: a genetic study. Epilepsia 16, 285-93 (1975).
16. Scheffer, I. E. et al. Autosomal dominant frontal epilepsy misdiagnosed as sleep disorder. Lancet 343, 515-517 (1994).
17. Ottman, R. & Susser, M. Data collection strategies in genetic epidemiology: the Epilepsy Family Study of Columbia University. J. din. Epidemiol. 45, 721-727 (1992).
18. Lathrop, G. M. & Lalouel, J. M. Easy calculations of lod scores and genetic risks on small computers. Am. J. hum. Genet. 36, 460-465 (1984).
19. Lathrop, G. M. & Lalouel, J. M. Efficient computations in multilocus linkage analysis. Am. J. hum. Genet. 42, 498-505 (1988).
20. Cottingham, R. W., Jr Idury, R. M. & Schaffer, A. A. Faster sequential genetic linkage computations. Am. J. hum. Genet. 53, 252-263 (1993).
21. Ottman, R. & Sherman, S. Genetic analysis of epilepsy in families ascertained from voluntary organizations [abstract]. Epilepsia 31, 611 (1990).
22. Gyapay, G. et al. The 1993-94 Genethon human genetic linkage map. Nature Genet. 7, 246-339 (1994).
23. Ottman, R., Lee, J. H., Hauser, W. A. & Risch, N. Birth cohort and familial risk of epilepsy: the effect of diminished recall in studies of lifetime prevalence. Am. J. Epidemiol. (in the press).
24. Weber, J. L. & May, P. E. Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am. J. hum. Genet. 44, 388-396 (1989).
25. Tautz, D. Hypervariability of simple sequences as a general source for polymorphic DNA markers. Nucl. Acids Res. 17, 6463-6471 (1989).