Design and Synthesis of Sialyl Lewis X Mimetics

Journal of the American Chemical Society

Volumn 117, Issue 19, 1995, Pages 5395-5396

  Uchiyama, Taketo ^a   Vassilev, Vassil P ^a   Kajimoto, Tetsuya ^a   Wong, Chi Huey ^a   Wong, Weichyun ^b   Huang, Hongmei ^b   Lin, Chun Cheng ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGOSACCHARIDE;

ARTICLE; BLOOD GROUP LEWIS SYSTEM; CARBOHYDRATE SYNTHESIS; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; MODEL;

EID: 0029059054     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja00124a037     Document Type: Article

References (13)

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2. Ichikawa, Y.; Lin, Y.-C.; Dumas, D. P.; Shen, G.-J.; Garcia-Junceda, E.; Williams, M. A.; Bayer, R.; Ketcham, C.; Walker, L. E.; Paulson, J. C.; Wong, C.-H. J. Am. Chem. Soc. 1992, 114, 9283.
3. x).
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12. The amino acid was prepared by L-threonine aldolase-catalyzed reaction of glycine (5 equiv) with O-benzylglycoaldehyde, pH 6.3 (78% yield). Vassilev, V. P.; Uchiyama, T.; Kajimoto, T.; Wong, C.-H. Tetrahedron Lett., in press.
13. The assay is similar to that previously reported: DeFrees, S. A.; Kosch, W.; Way, W.; Paulson, J. C.; Sabesan, S.; Halcomb, R.; Huang, D.-H.; Ichikawa, Y.; Wong, C.-H. J. Am. Chem. Soc. 1995, 117, 66. Detailed inhibition analysis will be published separately.