Novel Steroidal Inhibitors of Human Cytochrome P45017α (17α-Hydroxylase-C17,,20-lyase): Potential Agents for the Treatment of Prostatic Cancer

Journal of Medicinal Chemistry

Volumn 38, Issue 13, 1995, Pages 2463-2471

  Potter, Gerard A ^a   Barrie, S Elaine ^b   Jarman, Michael ^b   Rowlands, Martin G ^b  

^a Chiroscience Ltd   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

17 (3 PYRIDYL)ANDROSTA 4,16 DIEN 3 ONE; ABIRATERONE; ANTINEOPLASTIC AGENT; CYTOCHROME P450; LYASE INHIBITOR; PREGNENOLONE; PROGESTERONE; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; MALE; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION;

CYTOCHROME P-450 ENZYME SYSTEM; HUMAN; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PROSTATIC NEOPLASMS; STEROID 17-ALPHA-HYDROXYLASE; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; TESTIS;

EID: 0029058770     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00013a022     Document Type: Article

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