Neuroprotection after focal cerebral ischaemia in hyperglycaemic and diabetic rats

Neuroscience Letters

Volumn 197, Issue 1, 1995, Pages 53-56

  Bomont L ^a   MacKenzie, E T ^a  

^a UNIVERSITÉ DE CAEN   (France)

Author keywords

Diabetes mellitus; Dizocilpine; Fischer 344 rat; Focal cerebral ischaemia; Hyperglycaemia; Infarct volume; Insulin

Indexed keywords

DIZOCILPINE; INSULIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DIABETES MELLITUS; HYPERGLYCEMIA; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMAL; BRAIN ISCHEMIA; CEREBRAL ARTERIES; CEREBRAL INFARCTION; DIABETES MELLITUS, EXPERIMENTAL; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; MALE; RATS; RATS, INBRED F344; STEREOTAXIC TECHNIQUES;

EID: 0029056093     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(95)11899-8     Document Type: Article

References (20)

1. An autopsy study of cerebrovascular accident in diabetes mellitus
2. AMPA antagonists: do they hold more promise for clinical stroke trials than NMDA antagonists?
3. The effect of the NMDA receptor antagonist MK-801 on cerebral blood flow and infarct volume in experimental focal stroke
4. Hyperglycemia enlarges infarct size in cerebrovascular occlusion in cats
5. The quantification of cerebral infarction following focal ischemia in the rat: influence of strain, arterial pressure, blood glucose concentration, and age
6. Blood glucose and stroke
7. Influence of hyperglycemia on cerebral adenosine production during ischemia and reperfusion
8. Insulin-induced reduction of infarct volume after middle cerebral artery occlusion in rats
9. Dose-dependent improvement in metabolic recovery from hyperglycemic ischemia with tirilazad mesylate post-treatment
10. Effect of hyperglycemia on neuronal changes in a rabbit model of focal cerebral ischemia
11. Cerebral anti-ischaemic agents: problems and approaches
12. Transient focal ischemia in hyperglycemic rats is associated with increased cerebral infarction
13. The glutamate antagonist MK-801 reduces focal ischaemic brain damage in the rat
14. Increased damage after ischemic stroke in patients with hyperglycemia with or without established diabetes mellitus
15. Effect of dizocilpine on focal brain infarction in normotensive and hypertensive rats
16. Focal cerebral ischaemia in the rat. 1: description of technique and early neuropathological consequences following middle cerebral artery occlusion
17. Combined therapy with MK-801 and nimodipine for protection of ischemic brain damage
18. Hyperglycemic versus normoglycemic stroke: topography of brain metabolites, intracellular pH, and infarct size
19. Probability of stroke: a risk profile from the Framingham study
20. Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells