Nudging xenotransplantation towards humans

Nature Medicine

Volumn 1, Issue 5, 1995, Pages 403-404

  Fabre, John W ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT INHIBITOR;

ANTIBODY RESPONSE; ETHICS; GRAFT REJECTION; HEART GRAFT; HUMAN; LIVER TRANSPLANTATION; LUNG TRANSPLANTATION; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; REVIEW; TRANSGENIC ANIMAL; XENOTRANSPLANTATION;

ANIMAL; ENDOTHELIUM, VASCULAR; GALACTOSYLTRANSFERASES; GRAFT REJECTION; HAPLORHINI; HUMAN; SWINE; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS;

ANIMALIA;

EID: 0029056029     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm0595-403     Document Type: Article

References (13)

1. Carrel A. La technique operatoire des anastomoses vasculaires et la transplantation des visceres. Lyon Med. 98, 859-864 (1902)
2. Ullman, E. Experimenteile nierentrans-plantation. Wiener Klinische Wochenschrìft 11, 281-282 (1902).
3. von Decastello, A. Ueber experimenteile nierentransplantation. Wiener Klinische Wochenschrìft 12, 317 (1902).
4. Schwartz, R., Stack, J. & Dameshek, S. Effect of 6-mercaptopurine on antibody production. Proc, Soc. exp. Biol. 99, 164 (1958).
5. Caine, R.Y. The rejection of renal homografts. Inhibition in dogs by 6-mercaptopurine. Lancet 1, 417-418 (1960).
6. Zukowski, C.F., Lee, H.M. & Hume, D.M. The prolongation of functional survival of canine renal homografts by 6-mercaptopurine. Surg. Forum 11, 470 (1960).
7. McCurry, K.R., et al. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nature Med. 1, 423-427 (1995).
8. Galili, U. Interaction of the natural anti-Gal antibody with a-galactosyl epitopes: A major obstacle for xenotransplantation in humans. Immun. Today 14, 480-482 (1993).
9. Inverardi, L. & Pardi, R. Early events in cell-mediated recognition of vascularised xenografts: Cooperative interactions between selected lymphocyte subsets and natural antibodies. Immunol. Rev. 141, 71-93 (1994).
10. Sandrin, M.S., Vaughan, H.A., Dabkowski, P.L. & McKenzie, I.F.C. Anti-pig IgM antibodies in human serum react predominantly with Gal(al-3)Gal epitopes. Proc. natn. Acad. Sci. U.S.A. 90, 11391-11395 (1993).
11. Gustafsson, K., Strahan, K. & Preece, A. al, 3 Galactosyltransferase: A target for in vivo genetic manipulation in xenotransplantation. Immunol. Rev. 141, 59-70 (1994).
12. Sawyer, G.J., Gustafsson, K. & Fabre, J.W. Vascularised mouse-to-rat heart grafts: An unexpectedly difficult model of xenotransplantation. Transplantation Proc. 27, 309 (1995).
13. Ullman, E. Tissue and organ transplantation. Ann. Surg. 60, 195-219 (1914).